Effect of dexamethasone on hepatic glucose and insulin metabolism after oral glucose in conscious dogs.

Chap, Z.; Jones, R. H.; Chou, Jesse; Hartley, Craig J.; Entman, Mark L.; Field, James B.

doi:10.1172/jci112722

Cited by 25 publications

(13 citation statements)

References 33 publications

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“…3), the removal of insulin from plasma was reduced in glucocorticoidtreated mice and rats, compared to their CTL groups. These results are in accordance with previous reports in which hepatic insulin clearance was reduced in glucocorticoid-treated dogs [21] and in AI humans [22]. Glucocorticoid-treated rodents had lower insulin decay after the ipITT (Fig.…”

Section: Discussionsupporting

confidence: 93%

“…These findings corroborate the hypothesis that short-term and/or partial inhibition of the hepatic IDE expression may enhance the hypoglycemic action of insulin, which could be beneficial for the glycemic control [8,35]. Although reduced hepatic insulin clearance was previously reported to be associated with hyperinsulinemia in glucocorticoid-treated dogs [21] and in AI patients [22], we are the first to measure the hepatic IDE activity in insulin-resistant rats and mice made by glucocorticoid treatment.…”

Section: Discussionsupporting

confidence: 87%

“…Decreased hepatic insulin clearance seems to precede the b-cell compensation in obese dogs, and this hepatic adaptive mechanism contributes to the augmented circulating insulin levels during obesity [4]. In accordance, glucocorticoid-treated dogs [21] and insulin-resistant nondiabetic adrenal incidentaloma (AI) patients [22] exhibit decreased hepatic insulin clearance. However, the molecular mechanisms underlying this compensatory adaptation are unknown.…”

Section: Introductionmentioning

confidence: 97%

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Hyperinsulinemia caused by dexamethasone treatment is associated with reduced insulin clearance and lower hepatic activity of insulin-degrading enzyme

Protzek

Rezende

Costa-Júnior

et al. 2016

The Journal of Steroid Biochemistry and Molecular Biology

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 97%

See 1 more Smart Citation

Hyperinsulinemia caused by dexamethasone treatment is associated with reduced insulin clearance and lower hepatic activity of insulin-degrading enzyme

Protzek

Rezende

Costa-Júnior

et al. 2016

The Journal of Steroid Biochemistry and Molecular Biology

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“…The mechanism of reduced hepatic insulin extraction is unknown. A direct effect of glucocorticoids at the hepatic level can be proposed on the basis of previous results obtained in dogs after dexamethasone administration (Chap et al 1986). …”

Section: Discussionmentioning

confidence: 98%

Serum glucose, insulin and C-peptide response to oral glucose after intravenous administration of hydrocortisone and methylprednisolone in man

Bruno

Carucci

Cassader

et al. 1994

Eur J Clin Pharmacol

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Glucocorticoid-induced glucose intolerance and insulin resistance are dependent on the type of steroid, its dose and route of administration. Although the intravenous (i.v.) route is used mainly, the effects of different steroids have so far been compared using the oral route. The present study was therefore planned to compare the effects on glucose metabolism of hydrocortisone (HC) and methylprednisolone (MP) administered i.v. at equivalent antiinflammatory doses in healthy subjects. Eighteen healthy volunteers with normal glucose tolerance, divided into three groups (A,B,C) matched for age, sex and body mass index were subjected to oral glucose tolerance tests (oGTT) 12 h after HC or MP i.v. injection. The two tests were performed at a 1-month interval and in random sequence. Group A received low doses (HC 100 mg, MP 20 mg), group B intermediate doses (HC 200 mg, MP 40 mg) and group C high doses (HC 400 mg, MP 80 mg). Serum glucose, insulin and C-peptide were measured during both fasting and oGTT. Serum glucose values were not significantly different after HC or MP, during both fasting and oGTT. However, there was a positive correlation between fasting serum glucose or the area under the glucose curve and the dose.kg-1 body weight of HC (r = 0.748; r = 0.462) and MP (r = 0.708; r = 0.736). Serum insulin values were significantly higher after MP than after HC when fasting (A: 115 vs 223; B: 95 vs 215, C: 158 vs 268 pmol.l-1) and as area under the oGTT curve (A: 57.8 vs 87; B: 48.5 vs 92.1; C:57.8 vs 94.5 pmol.l-1 x 2 h).(ABSTRACT TRUNCATED AT 250 WORDS)

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“…In pregnant patients, hyperinsulinemia has been previously reported in asso ciation with both terbutaline and ritodrine therapy [8,9,11], Terbutaline and glucocorti coids also cause hyperinsulincmia in nonpreg nant subjects and dogs [7,27,28], Terbutaline is believed to directly stimu late (3-pancreatic cells and inhibit liver extrac tion of insulin [27], The glucocorticoid dexamethasone also decreases hepatic insulin ex traction and increases insulin secretion [28]. However, hyperglycemia appears to be the major stimulus for insulin release [27,28]. The simultaneous administration of terbutal ine and betamethasone appears to enhance the individual effect on insulin metabolism of each drug.…”

Section: Discussionmentioning

confidence: 99%

Combined Effect of Terbutaline and Betamethasone on Glucose Homeostasis in Preterm Labor

Adam¹,

Cotton

1993

Fetal Diagn Ther

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The short- and long-term effects of simultaneous administration of terbutaline and betamethasone were investigated in 8 gravidas treated for preterm labor. Their plasma concentrations of glucose, insulin, glucagon, C-peptide, lactate and potassium were compared to a control group receiving intravenous magnesium sulfate and betamethasone. The patients on terbutaline therapy had a marked hyperglycemia at 11 h which remained elevated for 48 h. There was a simultaneous rise in plasma insulin and C-peptide, and a fall in plasma glucagon. Lactate levels were markedly elevated. Only 1 of the 8 patients had an abnormal glucose tolerance test at 1 week of therapy. The metabolic changes of control patients were minimal in comparison and there was no lacticacidemia. This suggests that glucocorticoids potentiate the hyperglycemic response of terbutaline.

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Effect of dexamethasone on hepatic glucose and insulin metabolism after oral glucose in conscious dogs.

Cited by 25 publications

References 33 publications

Hyperinsulinemia caused by dexamethasone treatment is associated with reduced insulin clearance and lower hepatic activity of insulin-degrading enzyme

Hyperinsulinemia caused by dexamethasone treatment is associated with reduced insulin clearance and lower hepatic activity of insulin-degrading enzyme

Serum glucose, insulin and C-peptide response to oral glucose after intravenous administration of hydrocortisone and methylprednisolone in man

Combined Effect of Terbutaline and Betamethasone on Glucose Homeostasis in Preterm Labor

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