Combined Effect of Terbutaline and Betamethasone on Glucose Homeostasis in Preterm Labor

Adam, Karolina; Ou, Ching-Nan; Cotton, David B.

doi:10.1159/000263823

Cited by 6 publications

(2 citation statements)

References 19 publications

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“…Although many investigators have studied the effects of corticosteroids on glucose metabolism, 15 there are a limited number of studies investigating the effects of corticosteroids related to the diagnosis of gestational diabetes. Adam et al 16 found significant elevation in maternal hyperglycemia during the 11 to 48 hours period after combinated usage of oral terbutaline and betamethasone in 8 gravidas treated for preterm labor. However, only one of these eight cases had abnormal GTT at 1 week of therapy and this suggest that glucocorticoids potentiate the hyperglycemic response of terbutaline and this effect seems to be temporary.…”

Section: Discussionmentioning

confidence: 99%

Is 1-Hour Glucose Screening Test Reliable after a Short-Term Administration of Antenatal Betamethasone?

Gürbüz

Karateke²,

Öztürk³

et al. 2004

Am J Perinatol

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This study was designed to determine whether betamethasone has any effect on 1-hour (50-g) glucose screening test in nongestational diabetic pregnancy, and if any exists, to determine if this effect is transient or permanent. If the effect is temporary, the study was designed to determine the duration of this glucose intolerance effect and to determine the timing of 1-hour glucose screening test after betamethasone usage. One hundred fourteen pregnant women with a diagnosis of preterm labor at 24 to 34 weeks gestation were enrolled into the prospective study. One-hour glucose screening test was performed before initiation of hydration treatment. Forty pregnant women with normal 1-hour glucose results, who also had responded to hydration therapy, made up our study group. Twenty-four hours, 72 hours, and 1 week after administration of betamethasone, 50-g glucose challenge tests were again performed. A 3-hour glucose tolerance test was performed in pregnant women, whose 1-hour screening test had been positive 1 week after corticosteroid administration. In the evaluation of data, one-way, variance analysis and Tukey's multiple comparison test were used. The mean value of 1-hour glucose results of 50-g challenge test at the 24 hours was significantly higher than the mean value of 1-hour glucose results of the test done initially before betamethasone administration and than those of the tests done at 72 hours and 1 week (p < 0.001 for these three groups). There was no statistically significant difference between the mean values of 1-hour glucose results of the test done before betamethasone administration and both the results of the tests done at 72 hours (p = 0.96) and 1 week (p = 0.99), separately. There was no significant difference between the mean 1-hour glucose results of the tests at 72 hours and 1 week (p = 0.99). The test results were positive in 42.5%, 10%, and 5% of the patients, respectively at 24 hours, 72 hours, and 1 week. The betamethasone administration significantly deteriorates 1-hour glucose screening test results in the nongestational diabetic patients but this effect of betamethasone is transient. Because of its high false-positivity at 24 hours (42.5%) and at 72 hours (10%) in women with initial negative 1-hour glucose screening test, we suggest that 1-hour glucose screening test in pregnant women be postponed at least 1 week after betamethasone administration or perform the test before administration of betamethasone.

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Section: Discussionmentioning

confidence: 99%

Is 1-Hour Glucose Screening Test Reliable after a Short-Term Administration of Antenatal Betamethasone?

Gürbüz

Karateke²,

Öztürk³

et al. 2004

Am J Perinatol

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“…In der vorliegenden Arbeit zeigte sich eine mit anderen Studien [6,17] Einige Autoren fordern eine langfristige Nachbeobachtung der Kinder hinsichtlich ihrer psychomotorischen und neurologischen Entwicklung. Die Kürze der hyperglykämischen Intervalle lassen einen Einfluss allerdings unwahrscheinlich erscheinen.…”

Section: Zusammenfassung Und Diskussionunclassified

Glukosemessung mit dem kontinuierlich messenden Glukosesensor CGMS® bei stoffwechselgesunden Schwangeren während Betamethasontherapie zur fetalen Lungenreifeinduktion

Schumacher

Sidor

2006

Z Geburtshilfe Neonatol

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Gestational Diabetes Mellitus in Women Receiving Beta-Adrenergics and Corticosteroids for Threatened Preterm Delivery

Fisher

1997

Obstetrics &Amp; Gynecology

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Combined Effect of Terbutaline and Betamethasone on Glucose Homeostasis in Preterm Labor

Cited by 6 publications

References 19 publications

Is 1-Hour Glucose Screening Test Reliable after a Short-Term Administration of Antenatal Betamethasone?

Is 1-Hour Glucose Screening Test Reliable after a Short-Term Administration of Antenatal Betamethasone?

Glukosemessung mit dem kontinuierlich messenden Glukosesensor CGMS® bei stoffwechselgesunden Schwangeren während Betamethasontherapie zur fetalen Lungenreifeinduktion

Gestational Diabetes Mellitus in Women Receiving Beta-Adrenergics and Corticosteroids for Threatened Preterm Delivery

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