Effect of dexamethasone on bacteriostatic activity of turkey monocytes and implications for food safety

Huff, G. R.; Huff, W. E.; Rath, N. C.

doi:10.1016/j.vetimm.2015.05.006

Cited by 2 publications

(2 citation statements)

References 52 publications

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“…In fact, effect of dexamethasone on the WBC counts may depend on dose or animal kinds. Increased WBC counts were reported in female turkeys after dexamethasone treatment, but similar effect of dexamethasone was not observed in males (Huff et al 2015), and increased WBC counts were determined in cows (Thanasak et al 2004). These results may indicate dexamethasone directly affect WBC level in sheep and has no effect other hemogram values.…”

Section: Discussionmentioning

confidence: 59%

Effect of single dose dexamethasone (0.1 mg/kg) on white blood cell counts and serum glucose levels in healthy ewes

Er¹,

Dik²,

Çorum³

2016

EurasianJVetSci

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ÖzAmaç: Araştırmanın öncelikli amacı sağlıklı koyunlara tek doz deksametazon (0.1 mg/kg, SC) uygulamasının akyuvar sayısı ve serum glikoz düzeyine etkisini belirlemektedir. Ayrıca deksametazonun diğer bazı hemogram ve serum biyokimyasal parametrelere etkisi de değerlendirilmiştir. Gereç ve Yöntem:Araştırmada 8 adet sağlıklı Akkaraman koyuna 0.1 mg/kg (SC, tek doz) dozunda deksametazon uygulandı. Uygulamadan önce (0. saat, kontrol) ve sonraki 4, 8, 12, 24, 36, 48 ve 72. saatlerde kan örnekleri alındı. Akyuvar sayısı, alyuvar sayısı, platelet sayısı, hemogram ve hematokrit değerleri kan hücresi sayım cihazında ölçülürken, serum glikoz, laktat dehidrogenaz, alkalin fosfataz, total bilirubin, alanin aminotransferaz, aspartat aminotransferaz, gamma glutamiltransferaz, total protein, albümin, kan üre nitrojen, kreatinin, kolesterol, trigliserit, yüksek yoğunluklu lipoprotein ve düşük yoğunluklu lipoprotein düzeyleri otoanalizör-de ölçüldü.Bulgular: Kontrol (0. saat) zamanla karşılaştırıldığında, deksametazonun akyuvar sayısı ve serum glikoz düzeyini yük-selttiği (P<0.05) belirlendi ve bu yüksek düzeylerin 48 saat süresince devam ettiği gözlendi. Ayrıca total bilirubin, trigliserit ve kan üre nitrojen düzeylerinde istatistiki değişimler gözlendi, ancak bu değişimlerin referans aralıklar içinde olduğu tespit edildi.Öneri: Koyunlara deksametazon uygulamasının akyuvar sayısı ve serum glikoz düzeyini yükseltebileceği ve bu yüksek değerlerin 2-3 gün süresince belirlenebileceği ifade edilebilir.Anahtar kelimeler: Deksametazon, hemogram parametreler, biyokimyasal parametreler, koyun Abstract Aim: Aim of this research was to determine that effect of single dose dexamethasone (0.1 mg/kg, SC) on the white blood cell counts and serum glucose levels in healthy ewes. In addition, effects of dexamethasone on the other hemogram and serum biochemical values were evaluated. Materials and Methods:Totally healthy 8 Akkaraman sheep were received with 0.1 mg/kg (SC, single dose) dexamethasone. Blood samples were taken before (0. hour, control) and after treatments at 4, 8, 12, 24, 36, 48 and 72 hours. White blood cell, red blood cell, platelet, hematocrit and hemoglobin levels were measured by hemocell counter, whereas serum glucose, lactate dehydrogenase, alkaline phosphatase, total bilirubin, alanine aminotransferase, aspartate aminotransferase, gamma glutamyltransferase, total protein, albumin, blood urea nitrogen, creatinine, cholesterol, triglyceride, high density lipoprotein and low density lipoprotein levels were determined by auto-analyzer.Results: Dexamethasone increased (P<0.05) white blood cell and glucose levels when compared to Control (0 hour), and higher levels of these values were monitored during 48 hours. In addition, statistically significance changes were determined in the total bilirubin, triglyceride and blood urea nitrogen concentrations, but these results were within reference range. Conclusion:It may be stated that dexamethasone increases white blood cell count and glucose levels in sheep and its effect may be det...

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Section: Discussionmentioning

confidence: 59%

Effect of single dose dexamethasone (0.1 mg/kg) on white blood cell counts and serum glucose levels in healthy ewes

Er¹,

Dik²,

Çorum³

2016

EurasianJVetSci

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“…The mechanisms by which dexamethasone exerts its effects like hyperlipidemia are not fully recognized (18) . But, one is assured that the effects of dexamethasone are greatly depends on the dose of which, the period of treatment and the type of animal (19) .…”

Section: Discussionmentioning

confidence: 99%

Pharmacological Effects of Dexamethasone in Rats

2020

IJFMT

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Dexamethasone is one of the most widely used glucocorticoids which has a prominent glucocorticoid with slight mineralocorticoid property. This study was performed on twenty four adult Sprague Dawley rats to evaluate the proposed effects of dexamethasone offering as intraperitoneal injection. The animals were allocated randomly into three groups of eight rats to each. The protocol of experiment was: the control group; animals are injected intraperitoneally with 2ml of distilled water, the dexamethasone 1 group; animals are injected intraperitoneally with dexamethasone 2mg/kg, and the dexamethasone 2 group; animals are injected intraperitoneally with dexamethasone 4mg/kg. The injection period extended for one month. The results illustrate that dexamethasone cause significant declination in RBC, PCV, Hb, HDL, and neutrophils besides significant elevations in WBC, eosinophils, monocytes, LDL, TC, TG, VLDL, AST, ALT, and creatinine on a direct positive proportion with the increase in dexamethasone dose comparing with control group at (P≤0.05).

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Effect of dexamethasone on bacteriostatic activity of turkey monocytes and implications for food safety

Cited by 2 publications

References 52 publications

Effect of single dose dexamethasone (0.1 mg/kg) on white blood cell counts and serum glucose levels in healthy ewes

Effect of single dose dexamethasone (0.1 mg/kg) on white blood cell counts and serum glucose levels in healthy ewes

Pharmacological Effects of Dexamethasone in Rats

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