Effect of Depressive Symptoms on Survival After Heart Transplantation

Zipfel, Stephan; Schneider, Antonius; Wild, Beate; Löwe, Bernd; Jünger, Jana; Haass, Markus; Sack, Falk–Udo; Bergmann, G.; Herzog, Wolfgang

doi:10.1097/01.psy.0000031575.42041.6a

Cited by 52 publications

(43 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although some studies have suggested an association between symptoms of psychologic distress and mortality post-HTx, [15][16][17] others argued against this relation.…”

Section: Discussionmentioning

confidence: 99%

“…Advanced recipient age, advanced donor age and female-to-male mismatch have been identified as important risk factors in several reports, 4 -8 and do predict post-HTx mortality above and beyond depressive symptoms. 16 These risk factors and Type D were entered at the same time into a logistic regression model to determine whether Type D independently predicted unfavorable outcomes.…”

Section: Statistical Analysesmentioning

confidence: 99%

“…13,14 Little evidence has been published to date, but there is some indication that these symptoms might also predict long-term mortality after HTx. [15][16][17] Importantly, recipients have shown differences with regard to whether distress decreases after HTx, 18 and personality influences both post-transplant distress and non-compliance. 19,20 One study also found that postHTx mortality was increased in recipients who were characterized by chronic stress and inhibition in interpersonal situations.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Unfavorable Outcome of Heart Transplantation in Recipients With Type D Personality

Denollet

Vrints

et al. 2007

The Journal of Heart and Lung Transplantation

View full text Add to dashboard Cite

Unfavorable outcome of heart transplantation in recipients with type D personalityDenollet, Johan; Holmes, R.V.F.H.; Vrints, C.J.; Conraads, V. Published in:The Journal of Heart and Lung Transplantation Document version:Publisher's PDF, also known as Version of record General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.-Users may download and print one copy of any publication from the public portal for the purpose of private study or research -You may not further distribute the material or use it for any profit-making activity or commercial gain -You may freely distribute the URL identifying the publication in the public portal Take down policy If you believe that this document breaches copyright, please contact us providing details, and we will remove access to the work immediately and investigate your claim. Background: The role of personality in heart transplantation (HTx) remains largely unknown. We examined the distressed personality (Type D) as a predictor of outcomes in patients suffering from end-stage heart disease who underwent HTx. Methods:Using the DS14 scale, 51 patients (75% men; 54.1 Ϯ 9.7 years of age) were diagnosed as Type D or non-Type D in the pre-transplant period. End-points of this prospective follow-up study (mean 5.4 years) were mortality and allograft rejection (Grade Ն3A rejection, rejection-free days after HTx). Results:At baseline, 15 patients were diagnosed as Type D and 36 as non-Type D; they did not differ in recipient or donor characteristics. At follow-up, there were 8 deaths; the mortality rate of Type D recipients was 33% vs 8% for non-Type Ds ( p ϭ 0.036). Two deaths were due to early post-operative complications and were excluded from further analyses. Type D recipients had a 10-fold higher mortality rate after hospital discharge (5 of 15, or 33%) as compared with non-Type D recipients (1 of 34, or 3%) ( p ϭ 0.013, adjusting for age and gender). Among surviving recipients, the rate of Grade Ն3A rejection for both groups was 40% vs 27%, respectively (p ϭ 0.45). The first episode of rejection was diagnosed, on average, after 14 days in Type D recipients vs after 50 days in the other patients (p ϭ 0.032). The risk of unfavorable outcomes (death, Grade Ն3A rejection, or number rejection-free days Յ14) was greater in Type D recipients (12 of 15, or 80%) than in non-Type Ds (13 of 34, or 38%), adjusting for other risk factors (odds ratio: 6.75; 95% confidence interval: 1.47 to 30.97) ( p ϭ 0.014). Conclusions: Type D personality independently predicted mortality and early allograft rejection, and should be accounted for when planning interventions to achieve optimal outcomes after HTx. J Heart Lung Transplant 2007;26:152-8.

show abstract

“…Although some studies have suggested an association between symptoms of psychologic distress and mortality post-HTx, [15][16][17] others argued against this relation.…”

Section: Discussionmentioning

confidence: 99%

Section: Statistical Analysesmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Unfavorable Outcome of Heart Transplantation in Recipients With Type D Personality

Denollet

Vrints

et al. 2007

The Journal of Heart and Lung Transplantation

View full text Add to dashboard Cite

show abstract

“…A recent meta‐analysis of heart, liver, kidney, lung, and other solid organ transplant patients found depression in general to be related to adverse posttransplant outcomes 18. However, this meta‐analysis included only 4 (smaller single‐center) studies of HTx patients with a pretransplant assessment of depression, which have reported conflicting findings 19, 20, 21, 22. Social isolation was not evaluated in these studies.…”

mentioning

confidence: 99%

Role of Depression and Social Isolation at Time of Waitlisting for Survival 8 Years After Heart Transplantation

Spaderna

Zittermann

Reichenspurner

et al. 2017

JAHA

View full text Add to dashboard Cite

BackgroundWe evaluated depression and social isolation assessed at time of waitlisting as predictors of survival in heart transplant (HTx) recipients.Methods and ResultsBetween 2005 and 2006, 318 adult HTx candidates were enrolled in the Waiting for a New Heart Study, and 164 received transplantation. Patients were followed until February 2013. Psychosocial characteristics were assessed by questionnaires. Eurotransplant provided medical data at waitlisting, transplantation dates, and donor characteristics; hospitals reported medical data at HTx and date of death after HTx. During a median follow‐up of 70 months (<1–93 months post‐HTx), 56 (38%) of 148 transplanted patients with complete data died. Depression scores were unrelated to social isolation, and neither correlated with disease severity. Higher depression scores increased the risk of dying (hazard ratio=1.07, 95% confidence interval, 1.01, 1.15, P=0.032), which was moderated by social isolation scores (significant interaction term; hazard ratio = 0.985, 95% confidence interval, 0.973, 0.998; P=0.022). These findings were maintained in multivariate models controlling for covariates (P values 0.020–0.039). Actuarial 1‐year/5‐year survival was best for patients with low depression who were not socially isolated at waitlisting (86% after 1 year, 79% after 5 years). Survival of those who were either depressed, or socially isolated or both, was lower, especially 5 years posttransplant (56%, 60%, and 62%, respectively).ConclusionsLow depression in conjunction with social integration at time of waitlisting is related to enhanced chances for survival after HTx. Both factors should be considered for inclusion in standardized assessments and interventions for HTx candidates.

show abstract

“…La mayoría de estudios realizados hasta la fecha, refieren una morbilidad psiquiátrica elevada durante todo el proceso de TC, principalmente a expensas de trastornos depresivos y de ansiedad. Sin embargo, la influencia de las variables psiquiátricas en los resultados del TC no está claro y sólo un número limitado de estudios han examinado el papel pronóstico que ejercen, obteniendo resultados dispares (Zipfel et al, 2002;Owen et al, 2006;Havik et al, 2007;Okwuosa et al, 2014).…”

Section: Psicopatología Y Morbilidad Psiquiátricaunclassified

Evaluación de factores psiquiátricos y psicosociales en una cohorte de receptores de trasplante cardiaco: estudio de seguimiento a 12meses

Sánchez‐González¹

2016

Psiquiatría Biológica

View full text Add to dashboard Cite

Effect of Depressive Symptoms on Survival After Heart Transplantation

Cited by 52 publications

References 41 publications

Unfavorable Outcome of Heart Transplantation in Recipients With Type D Personality

Unfavorable Outcome of Heart Transplantation in Recipients With Type D Personality

Role of Depression and Social Isolation at Time of Waitlisting for Survival 8 Years After Heart Transplantation

Evaluación de factores psiquiátricos y psicosociales en una cohorte de receptores de trasplante cardiaco: estudio de seguimiento a 12meses

Contact Info

Product

Resources

About