Effect of Deferasirox on Iron Absorption in a Randomized, Placebo-Controlled, Crossover Study in a Human Model of Acute Supratherapeutic Iron Ingestion

Griffith, Erin A.; Fallgatter, Kiva C.; Tantama, Stephen S.; Tanen, David A.; Matteucci, Michael J.

doi:10.1016/j.annemergmed.2010.11.020

Cited by 6 publications

(2 citation statements)

References 16 publications

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“…Indications of potential serious toxicity include the following: ingestion of greater than 60 mg/kg of elemental iron; peak of serum iron concentration greater than 500 μg/dL (90 μmol/L); persistent serious symptoms such as vomiting, diarrhea, and/or altered mental status; presence of systemic symptoms, including subtle symptoms that can be seen in the latent phase of iron intoxication, such as tachycardia, hypotension, poor peripheral tissue perfusion, and/or tachypnea 18,20. In acute iron poisoning, intramuscular (IM) administration of deferoxamine is indicated for patients who are not in shock; intravenous (IV) administration should be reserved for patients in a state of cardiovascular collapse or shock.…”

Section: Discussionmentioning

confidence: 99%

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A Young Adult with Unintentional Acute Parenteral Iron intoxication Treated with Oral Chelation: The Use of Liver Ferriscan.

Yassin

Soliman

Sanctis³

et al. 2016

Mediterr J Hematol Infect Dis

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Acute iron intoxication (FeI) in humans has not been adequately studied. The manifestation of FeI, defined as a serum iron concentration >300 μg/dL (55 μmol/L) within 12 hours of ingestion, include various symptoms appearing in progressive stages. Systemic toxicity is expected with an intake of 60 mg/kg. A 27-year-old female nurse presented with unintended acute intravenous iron intoxication (FeI) a week after self-injecting herself with 20 ampoules of IV iron (4,000 mg elemental iron, 60 mg/kg). She had stable vital signs and mild hepatic tenderness. Hepatic MRI (Ferriscan®) showed a moderate/severe liver iron content (LIC: 9 mg/g dry tissue). Her hemogram, electrolytes, hepatic and renal functions were normal. Based on the high dose of iron received and her elevated LIC, chelation therapy was advised. She accepted only oral therapy and was started on deferasirox at a dose of 30 mg/kg daily. This oral chelation proved to be effective in clearing her hepatic iron overload after six months (LIC: 2 mg/g dry tissue), without side effects. This case also proved the value of Ferriscan® in diagnosing the degree of hepatic FeI and monitoring therapy to achieve a safe level of LIC.

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Section: Discussionmentioning

confidence: 99%

“…To determine the usefulness in management of acute iron ingestion, Griffith et al20 studied the effect of orally administered deferasirox in 8 healthy human adults. Subjects ingested 5 mg/kg of elemental iron in the form of ferrous sulfate.…”

Section: Discussionmentioning

confidence: 99%