Effect of DDT on Reproduction in the Rat

Ottoboni, Alice

doi:10.1097/00043764-197002000-00030

Cited by 5 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2001), suggesting a serious potential risk of p,p′‐ DDT for human reproduction through endocrine dysfunction. However, whether p,p′ ‐DDT does manifest such endocrine disruption in intact mammalian species has not yet fully been understood since only a limited number of data sets are available in terms of the reproductive and/or developmental toxicities (Ottoboni 1969; Rhouma et al . 2001; Takahashi et al .…”

Section: Introductionmentioning

confidence: 99%

“…A technical grade of DDT consists of approximately 80-85% of p,p′-DDT, 15% of o,p′-DDT and trace amounts of other components such as o,o′-DDT and p,p′-DDE (Ottoboni 1969;Kelce et al 1995). Both p,p′-DDT and o,p′-DDT can bind to nuclear estrogen receptors (ERs) but the binding affinity of p,p′-DDT to ERs is much lower than that of o,p′-DDT, suggesting relatively less potent estrogenicity of p,p′-DDT (Shelby et al 1996;Bolger et al 1998;Kanno et al 2003;Kojima et al 2003Kojima et al , 2004Fujimoto et al 2004;Charles et al 2005).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, p,p′-DDE, a major metabolite of p,p′-DDT, has been shown to © 2006 The Authors Journal compilation © 2006 Japanese Teratology Society have antiandrogenic activity (Wilson et al 2002;Yamasaki et al 2003;Yamada et al 2004) and to exert developmental toxicities in male rats (Kelce et al 1995;You et al 1998;Gray et al 2001), suggesting a serious potential risk of p,p′-DDT for human reproduction through endocrine dysfunction. However, whether p,p′-DDT does manifest such endocrine disruption in intact mammalian species has not yet fully been understood since only a limited number of data sets are available in terms of the reproductive and/ or developmental toxicities (Ottoboni 1969;Rhouma et al 2001;Takahashi et al 2001).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Two‐generation reproduction toxicity study in rats with 1,1,1‐trichloro‐2,2‐bis(4‐chlorophenyl)ethane (p,p′‐DDT)

Hojo¹,

Aoyama²,

Takahashi³

et al. 2006

Congenital Anomalies

View full text Add to dashboard Cite

DDT, an organochlorine pesticide, has been cited as a representative chemical suspected of having endocrine disrupting effects. In this study, the potential endocrine disrupting activities of p,p'-DDT, a major component of DDT, were investigated in rats in a 2-generation reproduction toxicity study in accordance with the most current test guidelines of the Ministry of Agriculture, Forestry and Fisheries in Japan, Organization for Economic Cooperation and Development (OECD) and United States Environmental Protection Agency (USEPA) with some modifications and additions. p,p'-DDT was given to parental rats at dietary levels of 0, 5, 50 or 350 ppm. Systemic toxicities in the parental animals consisted of tremors and subsequent deaths (females only) and/or pathological alterations of the liver (both sexes of animals) of the 2 higher dose groups. Reproductive and postnatal developmental toxicities were not evident up to the highest dose level except for the decreased pup viability index on postnatal day 21 in the 350 ppm group. Changes in serum estradiol and progesterone levels and/or a delay in male sexual maturation were noted in the 2 higher dose groups in a dose-dependent fashion, suggesting alterations of endogenous endocrine functions. However, these changes never resulted in substantial reproductive disorders.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Two‐generation reproduction toxicity study in rats with 1,1,1‐trichloro‐2,2‐bis(4‐chlorophenyl)ethane (p,p′‐DDT)

Hojo¹,

Aoyama²,

Takahashi³

et al. 2006

Congenital Anomalies

View full text Add to dashboard Cite

show abstract

“…The experiments on rats fed a diet containing 2.4 ppm (Feaster et al, 1972) or 20 and 200 ppm (Ottoboni, 1969) showed no effect on fecundity.…”

mentioning

confidence: 84%

Mutagenicity, Carcinogenicity, and Teratogenicity of Industrial Pollutants

Kirsch‐Volders¹

1984

View full text Add to dashboard Cite

“…Commercialized technical DDT consisted of a major component p,p'-DDT and its isomer of o,p '-DDT (15-2070) which is known to have estrogenic activity (Kuiper et al, 1998). Technical DDT has been reported to cause ringtail in rat pups at dietary concentrations of 20 and 200 ppm in twogeneration reproduction studies (Ottoboni, 1969). However, this alteration is not a congenital anomaly but a disease of obscure etiology that affects suckling rats.…”

Section: Introductionmentioning

confidence: 99%

Prenatal developmental toxicity studies of 1,1,1‐trichloro‐2,2‐bis(4‐chlorophenyl)ethane (p, p‘‐DDT) in rats and rabbits

Takahashi¹,

Aoyama²,

Hojo³

et al. 2001

Congenital Anomalies

View full text Add to dashboard Cite

The studies were conducted in rats and rabbits to elucidate the potential developmental toxicity of p, p'‐DDT in general accordance with the improved Japanese MAFF guidelines (12‐Nousan‐No. 8147,2–1–18, 2000). p, p'‐DDT suspended in 1% aqueous solution of CMC was administered orally to pregnant Jcl:SD rats on gestational days (GD) 6–19 at a dose of 0,5, 25, or 100 mg/kg/day and to pregnant KbI: JW rabbits on GD 6–27 at a dose of 0,5,20, or 80 mg/kg/day. Maternal animals were killed on the day after the last day of administration for morphological examination of their fetuses with special attention to the reproductive organs. Adverse effects on maternal animals were found only at the highest dose in both species; i.e., clonic convulsion (2/24 in rats, 5/22 in rabbits), mortality (1/24 in rats), abortion or premature delivery (4/22 in rabbits), and reduced body weight gains and food consumption. However, the control and treated groups showed comparable values for the numbers of corpora lutea and implants, percent preimplantation losses, number of live fetuses, percent resorptions and fetal deaths, sex ratio, fetal body weights, and placental weights in both species, and anogenital distance and testicular histology in rats. Although fetal examination revealed slightly increased incidence of 27 presacral vertebrae in the highest dose group in rats, there was no treatment‐related increase in the incidence of malformations in any of the species. Based on these results, it is concluded that p, p'‐DDT causes no malformations, including male reproductive organ abnormalities, in either rats or rabbits, although it results in an increased incidence of skeletal variations in rats at a maternally toxic dose.

show abstract

Effect of DDT on Reproduction in the Rat

Cited by 5 publications

References 0 publications

Two‐generation reproduction toxicity study in rats with 1,1,1‐trichloro‐2,2‐bis(4‐chlorophenyl)ethane (p,p′‐DDT)

Two‐generation reproduction toxicity study in rats with 1,1,1‐trichloro‐2,2‐bis(4‐chlorophenyl)ethane (p,p′‐DDT)

Mutagenicity, Carcinogenicity, and Teratogenicity of Industrial Pollutants

Prenatal developmental toxicity studies of 1,1,1‐trichloro‐2,2‐bis(4‐chlorophenyl)ethane (p, p‘‐DDT) in rats and rabbits

Contact Info

Product

Resources

About