Effect of Daily Consumption of a Synbiotic Food on Pregnancy Outcomes: A Double-Blind Randomized Controlled Clinical Trial

Taghizadeh, Mohsen; Alizadeh, Sabihe‐Alsadat; Asemi, Zatollah

doi:10.17795/whb-27195

Cited by 3 publications

(2 citation statements)

References 31 publications

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“…Lactobacillus sporogenes and inulin in pregnant women [48]. Furthermore, a recent metaanalysis showed that consumption of probiotic among pregnant women after week 36 of gestation did not affect the gestational age at birth, the incidence of caesarean section and birth weight [49].…”

Section: S T a C C E P T E D Hyperbilirubinemia And Cesarean Section mentioning

confidence: 99%

RETRACTED ARTICLE: The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes

Badehnoosh

Karamali

Zarrati

et al. 2017

The Journal of Maternal-Fetal & Neonatal Medicine

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120

143

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Section: S T a C C E P T E D Hyperbilirubinemia And Cesarean Section mentioning

confidence: 99%

RETRACTED ARTICLE: The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes

Badehnoosh

Karamali

Zarrati

et al. 2017

The Journal of Maternal-Fetal & Neonatal Medicine

Self Cite

120

143

View full text Add to dashboard Cite

show abstract

“…Moreover, in the study by Nikniaz et al 42 synbiotic supplementation increased the total antioxidant capacity of breast milk.In another study by Nabhani et al 7 synbiotic supplementation significantly reduced both SBP and DBP. Although Karamali et al 19 concluded that synbiotic supplementation can have a positive effect on pregnancy outcomes,Taghizadeh et al 43 showed that consumption of synbiotics among pregnant women does not affect pregnancy outcomes.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Probiotics or Synbiotics on the Hypertensive Disorders of Pregnant Women with Gestational Diabetes: A Systematic Review and Meta-analysis

et al. 2022

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Introduction:Antioxidants and anti-inflammatory drugs have been suggested to treat preeclampsia. This systematic review and meta-analysis was conducted to investigate the efficacy of probiotic or synbiotic supplementation on hypertensive disorders in women with gestational diabetes mellitus (GDM).Methods:The databases including Cochrane, Embase, Ovid, ProQuest, Scopus, Web of Science, and PubMed were systematically searched for collecting the randomized controlled trials (RCTs) investigating the efficacy of probiotic or synbiotic supplementation versus placebo on hypertensive disorders and pregnancy outcomes in GDM until July 2020.Results:Five RCTs with a total sample size of 402 women were included in the meta-analysis. There was no significant decline in systolic blood pressure (standardized mean difference [SMD] = -3.41, 95% confidence interval [CI] = -8.32 to 1.50, P = 0.17), diastolic blood pressure (SMD = -5.11, 95% CI = -14.20 to -3.98, P = 0.27), preeclampsia (odds ratio [OR] = 1.56, 95% CI = 0.61 to 3.98, P = 0.35), cesarean section (OR = 0.52, 95% CI = 0.18 to 1.50, P = 0.23), and macrosomia (OR = 0.81, 95% CI = 0.41 to 1.57, P = 0.53). No significant increase was observed in terms of 5-minute Apgar (SMD = 0.16, 95% CI = -0.06 to 0.39, P = 0.15, I2= 0%), birth weight (SMD = -0.18, 95% CI = -0.43 to 0.06, P = 0.13, I2= 0%), and gestational age (SMD = 0.13, 95% CI = -0.11 to 0.37, P = 0.28, I2= 0%).Conclusion:Probiotic or synbiotic supplements are not associated with significant effects on pregnancy outcomes in GDM. However, due to the limited number of studies in this regard and heterogeneity between studies, future high-quality RCTs are recommended.

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Pregnancy outcomes in women taking probiotics or prebiotics: a systematic review and meta-analysis

Jarde

Lewis-Mikhael

Martin

et al. 2018

BMC Pregnancy Childbirth

122

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BackgroundProbiotics are living microorganisms that, when administered in adequate amounts, confer a health benefit. It has been speculated that probiotics might help prevent preterm birth, but in two previous systematic reviews possible major increases in this risk have been suggested. Our objective was to perform a systematic review and meta-analysis of the risk of preterm birth and other adverse pregnancy outcomes in pregnant women taking probiotics, prebiotics or synbiotics.MethodsWe searched six electronic databases (MEDLINE, EMBASE, CINAHL, Cochrane Central Register of Controlled Trials, Web of Science’s Core collection and BIOSIS Preview) up to September 2016 and contacted authors for additional data. We included randomized controlled trials in which women with a singleton pregnancy received a probiotic, prebiotic or synbiotic intervention. Two independent reviewers extracted data using a piloted form and assessed the risk of bias using the Cochrane risk of bias tool. We used random-effects meta-analyses to pool the results.ResultsWe identified 2574 publications, screened 1449 non-duplicate titles and abstracts and read 160 full text articles. The 49 publications that met our inclusion criteria represented 27 studies. No study used synbiotics, one used prebiotics and the rest used probiotics. Being randomized to take probiotics during pregnancy neither increased nor decreased the risk of preterm birth < 34 weeks (RR 1.03, 95% CI 0.29–3.64, I2 0%, 1017 women in 5 studies), preterm birth < 37 weeks (RR 1.08, 95% CI 0.71–1.63, I2 0%, 2484 women in 11 studies), or most of our secondary outcomes, including gestational diabetes mellitus.ConclusionsWe found no evidence that taking probiotics or prebiotics during pregnancy either increases or decreases the risk of preterm birth or other infant and maternal adverse pregnancy outcomes.Trial registrationWe prospectively published the protocol for this study in the PROSPERO database (CRD42016048129).Electronic supplementary materialThe online version of this article (10.1186/s12884-017-1629-5) contains supplementary material, which is available to authorized users.

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Effect of Daily Consumption of a Synbiotic Food on Pregnancy Outcomes: A Double-Blind Randomized Controlled Clinical Trial

Cited by 3 publications

References 31 publications

RETRACTED ARTICLE: The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes

RETRACTED ARTICLE: The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes

The Effect of Probiotics or Synbiotics on the Hypertensive Disorders of Pregnant Women with Gestational Diabetes: A Systematic Review and Meta-analysis

Pregnancy outcomes in women taking probiotics or prebiotics: a systematic review and meta-analysis

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