Abstract:Granulation tissue was produced by subcutaneous implantation of viscose‐cellulose sponges on rats. The effect of D‐penicillamine 500 mg/kg/day for 10 days on granulation tissue and the connective tissue of skin, bone and aorta was studied by comparison of treated animals with operated and unoperated controls. In addition, the effect of sponge implantation on intact tissues was studied by comparison between the control groups. The amount of granulation tissue was not affected by D‐penicillamine, and the granulo… Show more
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