The effects of lathyrogens on intestinal anastomoses in the rat

Doorn, Kevin van; Man, Boris; Hendriks, T.

doi:10.1016/0014-4800(90)90056-j

Cited by 13 publications

(4 citation statements)

References 19 publications

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“…In the TPN group, the nutrient solution was administered via a central venous catheter, which is a suitable model of the classical management using parenteral nutrition during a fasting period. Anastomotic bursting pressure was determined 5 days postoperatively in this study, because it has been reported that after 7 days anastomoses that rupture predominantly do so outside the anastomosis [16][17][18], and anastomotic insufficiency usually occurs during the first postoperative week. We chose the bursting pressure applied because some reports have demonstrated that breaking strength is not sensitive enough to detect early changes in anastomotic healing within one week.…”

Section: Discussionmentioning

confidence: 99%

Early Postoperative Oral Feeding Accelerates Upper Gastrointestinal Anastomotic Healing in the Rat Model

2007

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Section: Discussionmentioning

confidence: 99%

Early Postoperative Oral Feeding Accelerates Upper Gastrointestinal Anastomotic Healing in the Rat Model

2007

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“…Dehiscence of bowel anastomoses appears mainly a problem in the large intestine. 11 Explanations for this difference between small and large bowel are speculative and it is unknown ifmolecular events which occur during healing differ between both bowel segments. If so, they might indicate how to proceed in order to improve colonic anastomotic repair.…”

Section: Discussionmentioning

confidence: 99%

Postoperative changes in collagen synthesis in intestinal anastomoses of the rat: differences between small and large bowel.

Martens

Hendriks

1991

Gut

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Collagen synthesis is an essential feature of anastomotic healing in the intestine. Postoperative collagen synthesis, measured in vitro in intestinal anastomoses was studied from three hours to 28 days after operation. For this purpose, an ileal and a colonic anastomosis were constructed within the same animal and the results in both intestinal segments were compared. In the ileum, coliagen synthesis was significantly increased, with respect to unoperated controls, three hours after operation. It remained raised during the period of study, with a maximal 10-fold stimulation four days after operation, and had nearly returned to the preoperative level after four weeks. The general pattern was the same in the colon, although quantitatively different: the increase in synthetic activity was delayed in comparison with the ileum. Maximal stimulation was approximately six-fold. In addition, we calculated the ratio for each rat between anastomotic coliagen synthesis and the average value found in non-operated control animals. Postoperative stimulation in the ileum was higher than in the colon in almost every animal examined. The results show that the ileum responds more quickly and strongly to wounding than the colon, at least as far as the production of new coliagen is concerned. Possibly, this phenomenon contributes to the lower failure rate apparent for anastomoses in the smali bowel. The strength of the intact and the anastomosed bowel wall is derived from collagen fibrils, located predominantly in the submucosa,2 3 which connective layer forms the backbone of the intestine. During the first postoperative days anastomotic strength is low and anastomotic collagen levels change massively.4 It is generally assumed that the transiently lowered collagen concentrations, observed during normal healing, are the result of early, although limited, collagen degradation followed by considerable collagen synthesis. While early anastomotic strength depends on the suture holding capacity of existing collagen fibrils, newly formed collagen is needed to bridge the gap and restore the original strength of the bowel wall. Thus, the progress of collagen synthesis plays a central role in the healing sequence: disturbance ofits regulation will affect anastomotic strength and might enhance chances for dehiscence.The occurrence of collagen synthesis around experimental intestinal anastomoses has been shown in vivo, in the ileum5 and in the colon6 from two days after operation onwards. The methodology used for such experiments requires administration of large amounts of radioactive proline to animals and precludes the measurement of synthesis in the immediate postoperative period as the precursor needs to be injected at least 24 hours before death.6 A system to measure collagen synthesis in intestinal explants has recently been established.7 This in vitro system allows measurement immediately after operation and appears suitable to initiate research on the effects ofpotentially regulatory factors. Here, we report on the postoperative...

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“…The ABP in the TPN þ water group suggested a lower trend than that in the TPN þ saline group. ABP was determined 5 d postoperatively in this study as well as in a previous study [13] because it has been reported that after 7 d the anastomoses that rupture predominantly do so outside the anastomosis [19][20][21], and anastomotic insufficiency usually occurs during the first postoperative week. The ABP is a more reliable measure for evaluating early postoperative anastomotic mechanical strength, especially within a week of the operation [22,23].…”

Section: Discussionmentioning

confidence: 99%

Early Postoperative Oral Intake Accelerates Upper Gastrointestinal Anastomotic Healing in the Rat Model

Tadano

Terashima

Fukuzawa

et al. 2011

Journal of Surgical Research

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The effects of lathyrogens on intestinal anastomoses in the rat

Cited by 13 publications

References 19 publications

Early Postoperative Oral Feeding Accelerates Upper Gastrointestinal Anastomotic Healing in the Rat Model

Early Postoperative Oral Feeding Accelerates Upper Gastrointestinal Anastomotic Healing in the Rat Model

Postoperative changes in collagen synthesis in intestinal anastomoses of the rat: differences between small and large bowel.

Early Postoperative Oral Intake Accelerates Upper Gastrointestinal Anastomotic Healing in the Rat Model

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