Effect of cysteamine administration on growth and efficiency of food utilisation in chicks

Zavy, M. T.; Lindsey, T. O.

doi:10.1080/00071668808417066

Cited by 6 publications

(3 citation statements)

References 17 publications

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“…Zavy & Lindsey (1988) observed decreased feed intake in 3 Obtained by the addition of the source of cysteamine in replacement of kaolin (inert material). * Enrichment of vitamins and microminerals in energy pattern 2 with increased supplementation of the premixes for maintenance of the nutrient:calorie ratio.…”

Section: Resultsmentioning

confidence: 99%

“…Potentially positive results with cysteamine supplementation for broiler chickens were found by Zavy & Lindsey (1988) and Yang et al (2006), but there is no technical consensus about which supplementation level should be utilized according to the rearing phases of those birds. There is, in general, a limitation of recent studies with this additive for species of economic interest such as birds, pigs and fish, making clear the importance of new studies which come to collaborate with information about the physiological effects and thus variables of general interest such as weight gain, feed conversion and carcass yield.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of cysteamine associated with different energy patterns in diets for broiler chickens

et al. 2012

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-This experiment was conducted with the objective of evaluating cysteamine (CS) supplementation in broiler chick diets with different energy density patterns. A total of 980 chicks of the Cobb 500 strain at one day of age were allocated into 28 plots. A completely randomized design in a 2 × 2 factorial arrangement, with 7 replications, was adopted. The factors under study were the supplementation (or absence) of cysteamine (60 mg/kg and 80 mg/kg of feed in the starter and growth/finishing phases, respectively) and two patterns of apparent metabolizable energy corrected by nitrogen balance (AMEn) in the diets. The energy levels (Mcal/kg of feed) practiced in pattern 1 were 3.00; 3.10; and 3.20, and for pattern 2, they were 3.05; 3.20; and 3.30 in the starter, growth and finishing phases, respectively. The diets were on the basis of corn and soybean meal with a feeding program with three diets. Feed intake, weight gain, feed conversion, feasibility and carcass yield were evaluated. There was no interaction between the CS supplementation and AME patterns in the diet upon the performance and/or carcass characteristic evaluated. Broilers fed the diet supplemented with CS presented improved feed conversion along the rearing cycle, but feed intake and weight gain were not affected by the supplementation of CS. The highest pattern of energy density (2) provided increased weigh gain in the starter phase of rearing and better feed conversion of the birds over the whole rearing period. The carcass yield was not influenced by the cysteamine supplementation and/or energy levels studied.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of cysteamine associated with different energy patterns in diets for broiler chickens

et al. 2012

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“…The growth-promoting effect of cysteamine has been demonstrated in fish and chicken ,, , and the efficacy of cysteamine seems to depend on dose, timing and route of administration, duration of use, species, and the metabolic and physiological state of the animal. No data are available describing the growth-promoting effect of CSH in mammals to our knowledge.…”

Section: Discussionmentioning

confidence: 99%

Tissue-Specific Effect of Dietary Cysteamine on Expression of Adiponectin Receptors in Rats

Shao

Chi

et al. 2007

J. Agric. Food Chem.

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Adiponectin is synthesized by adipocytes and affects glucose and lipid metabolism by binding to its receptors, AdipoR1 and AdipoR2. Cysteamine, a naturally existing intermediate metabolite of sulfur amino acid, has been reported to modulate metabolism and growth in various species of animals; however, whether the action of cysteamine involves adiponectin and its receptors is unknown. The objective of the present study was therefore to investigate the effect of dietary cysteamine on the expression of AdipoR1/R2 in different tissues, in association with the alterations in endocrine and metabolic status. Rats were fed either of the diets supplemented with 0 or 700 mg/kg cysteamine feed additive (containing 30% of cysteamine hydrochloride) for 4 weeks, and the expression of adiponectin and its receptors in adipose tissue, AdipoR1 and AdipoR2 in liver, gastrocnemius, and soleus muscle was determined, in association with the growth performance and serum concentrations of hormones and metabolites. A temporal trend of increase in growth rate and the ratio of feed consumption relative to body weight gain was observed in the second week of cysteamine supplementation. Serum concentrations of insulin and TNF-alpha increased, while serum levels of triglycerides, FFA, and total cholesterol decreased significantly 4 weeks after cysteamine treatment. Leptin and GH remained unaffected. Cysteamine supplementation increased mRNA expression of AdipoR1 in adipose tissue, gastrocnemius, and soleus muscle as well as that of AdipoR2 in soleus muscle and adipose tissue. Nevertheless, hepatic expression of AdipoR1 and AdipoR2 was not influenced. Despite a numeric increase, no significant alteration in adiponectin mRNA expression in adipose tissue was observed. In conclusion, dietary supplementation of cysteamine modulates the endocrine and metabolic status of rats, which may involve the tissue-specific responses of adiponectin receptors at the level of mRNA transcription.

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Stimulation of mucosal uptake of selenium from selenite by some thiols at various sites of rat intestine

Scharrer

Senn

Wolffram

1992

Biol Trace Elem Res

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The influence of several thiols (conc. 1 mmol/L) on mucosal uptake of 75Se from 75Se-labeled selenite (conc. 10 mumol/L) across the brush border of rat jejunum and cecum was investigated in vitro using a short-term uptake technique. L-Cysteine (L-Cys) stimulated 75Se uptake in the mid- and distal jejunum and cecum, but not in the proximal jejunum. The effect was maximal in the distal jejunum. D-Cys was less effective in the jejunum and similarly effective in the cecum. L-Leucine (L-Leu) and L-glutamic acid significantly reduced the stimulatory effect of L-Cys on Se uptake in the distal jejunum, whereas the respective effect of D-Cys was not diminished by L-Leu. Cysteamine stimulated mucosal 75Se uptake at all intestinal sites tested, whereas the effect of mercaptopyruvate was restricted to the distal jejunum. Thioglycolate also enhanced 75Se uptake in the distal jejunum. The stimulatory effects of L-Cys, mercaptopyruvate, and thioglycolate were Na(+)-dependent, whereas the effect of cysteamine also occurred in the absence of Na+. Mercaptosuccinate, D-penicillamine, ergothioneine, and thiosulfate did not enhance mucosal 75Se uptake. It is concluded from these findings that the reaction of some thiols with selenite results in Se compounds that are rapidly absorbed by the intestinal epithelium through various Na(+)-dependent and Na(+)-independent mechanisms. The high bioavailability of Se from selenite found by others might thus be the result of the presence of thiols in the gastrointestinal tract.

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Effect of cysteamine administration on growth and efficiency of food utilisation in chicks

Cited by 6 publications

References 17 publications

Evaluation of cysteamine associated with different energy patterns in diets for broiler chickens

Evaluation of cysteamine associated with different energy patterns in diets for broiler chickens

Tissue-Specific Effect of Dietary Cysteamine on Expression of Adiponectin Receptors in Rats

Stimulation of mucosal uptake of selenium from selenite by some thiols at various sites of rat intestine

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