Effect of Cynara cardunculus L. var. altilis (DC) in Inflammatory Bowel Disease

Mateus, Vanessa; Estarreja, João; Silva, Inês; Barracosa, Paulo; Lemos, E. Teixeira de; Pinto, Rui

doi:10.3390/app11041629

Cited by 8 publications

(4 citation statements)

References 43 publications

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“…However, it did not reverse hepatic alterations induced by colitis. This study highlights the anti-inflammatory potential of CCLE and suggests its role as a complementary therapeutic approach for IBD management, with potential applications in chronic cases and through oral administration [53].…”

Section: Beneficial Health Effects Of Artichoke On Inflammatory and G...mentioning

confidence: 84%

Insights into the Biological Roles of Artichoke Extracts: Implications in Intestinal, Cardiovascular, and Neurodegenerative Diseases

Porro,

Benameur,

Cianciulli

et al. 2023

Preprint

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Several chronic diseases derive from metabolic, genetic, or inflammatory causes and often these causes are interconnected. Pharmacological treatments, although effective, often lead to unpleasant side effects. In this context, preventive approaches are of growing interest. The literature data of recent years support that the dietary intake of bioactive compounds can positively influence the biological functions of an organism. Among the bioactive compounds in the diet, polyphenols are widely recognized for their beneficial effects on health, as useful compounds for preventing/combating a series of pathologies related to lifestyle, metabolism, and aging. The artichoke (Cynara scolymus L.), a member of the Asteraceae family, is widely used in the food and herbal medicine fields for its beneficial properties. Artichokes are rich in polyphenols (including cynarin), flavonoids and their derivatives, and, for this reason, they have aroused interest in their pharmacological properties. The best-known activity of polyphenols is antioxidant activity. Through it, they help to neutralize free radicals, preventing cellular damage and the subsequent risk of conditions such as cancer, diabetes, and heart disease. Related to the antioxidant action we find the anti-inflammatory activity. This is an important benefit since chronic inflammation is a cause or contributory cause of many chronic diseases. Although many scientific results are of great interest and potential, there are still gaps to be filled. In this review, we report and discuss new insights providing documented evidence regarding the benefits of the artichoke compounds and their possible use to support the pharmacological treatment of pathologies associated with inflammation.

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Section: Beneficial Health Effects Of Artichoke On Inflammatory and G...mentioning

confidence: 84%

Insights into the Biological Roles of Artichoke Extracts: Implications in Intestinal, Cardiovascular, and Neurodegenerative Diseases

Porro,

Benameur,

Cianciulli

et al. 2023

Preprint

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“…First, on day 0 (induction day), the mice were anesthetized with 40 μL of a mixture of ketamine 100 mg/kg + xylazine 10 mg/kg by an intraperitoneal (IP) injection. TNBS was instilled through a single intrarectal (IR) administration [ 16 , 20 , 21 , 22 , 23 ]. The technique consisted of the insertion of a cannula into the colon, such that the tip was 4 cm proximal to the anus, and then 100 μL of TNBS 1.0% was administrated over five weeks.…”

Section: Methodsmentioning

confidence: 99%

Hemin Ameliorates the Inflammatory Activity in the Inflammatory Bowel Disease: A Non-Clinical Study in Rodents

et al. 2022

Self Cite

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Background: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract. Currently, there is no cure, and pharmacological treatment aims to induce and maintain remission in patients, so it is essential to investigate new possible treatments. Hemin is a heme-oxygenase inducer which can confer anti-inflammatory, cytoprotective, and antiapoptotic effects; therefore, it can be considered an asset for different gastrointestinal pathologies, namely for IBD. Aim: This experiment aims to evaluate the efficacy and safety of hemin, in a chronic 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis model in rodents. Methods: The induction of chronic colitis consisted of five weekly intrarectal administrations of 1% TNBS. Then, the mice were treated daily with 5 mg/kg/day or 10 mg/kg/day of hemin, through intraperitoneal injections, for 14 days. Results: Hemin demonstrated an anti-inflammatory effect through the reduction in tumor necrosis factor (TNF)-α levels, fecal calprotectin, and fecal hemoglobin. It was also found to be safe in terms of extraintestinal manifestations, since hemin did not promote renal and/or hepatic changes. Conclusions: Hemin could become an interesting tool for new possible pharmacological approaches in the management of IBD.

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“…However, it did not reverse the hepatic alterations induced by colitis. This study highlights the anti-inflammatory potential of CCLE and suggests its role as a complementary therapeutic approach for IBD management, with potential application in chronic cases and through oral administration [ 54 ].…”

Section: Inflammatory and Gastrointestinal Diseases And Artichokementioning

confidence: 99%

Functional and Therapeutic Potential of Cynara scolymus in Health Benefits

Porro,

Benameur,

Cianciulli

et al. 2024

Nutrients

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Dietary supplements enriched with bioactive compounds represent a promising approach to influence physiological processes and enhance longevity and overall health. Cynara cardunculus var. scolymus serves as a functional food supplement with a high concentration of bioactive compounds, which offers various health-promoting benefits. Several chronic diseases have metabolic, genetic, or inflammatory origins, which are frequently interconnected. Pharmacological treatments, although effective, often result in undesirable side effects. In this context, preventive approaches are gaining increased attention. Recent literature indicates that the consumption of bioactive compounds in the diet can positively influence the organism’s biological functions. Polyphenols, well-known for their health benefits, are widely recognized as valuable compounds in preventing/combating various pathologies related to lifestyle, metabolism, and aging. The C. scolymus belonging to the Asteraceae family, is widely used in the food and herbal medicine fields for its beneficial properties. Although the inflorescences (capitula) of the artichoke are used for food and culinary purposes, preparations based on artichoke leaves can be used as an active ingredient in herbal medicines. Cynara scolymus shows potential benefits in different domains. Its nutritional value and health benefits make it a promising candidate for improving overall well-being. C. scolymus exhibits anti-inflammatory, antioxidant, liver-protective, bile-expelling, antimicrobial, and lipid-lowering neuroprotective properties. Different studies demonstrate that oxidative stress is the leading cause of the onset and progression of major human health disorders such as cardiovascular, neurological, metabolic, and cancer diseases. The large amount of polyphenol found in C. scolymus has an antioxidant activity, enabling it to neutralize free radicals, preventing cellular damage. This reduces the subsequent risk of developing conditions such as cancer, diabetes, and cardiovascular diseases. Additionally, these polyphenols demonstrate anti-inflammatory activity, which is closely associated with their antioxidant properties. As a result, C. scolymus has the potential to contribute to the treatment of chronic diseases, including intestinal disorders, cardiovascular diseases, and neurodegenerative pathologies. The current review discussed the nutritional profiles, potential benefits, and pharmacological effects of C. scolymus.

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Effect of Cynara cardunculus L. var. altilis (DC) in Inflammatory Bowel Disease

Cited by 8 publications

References 43 publications

Insights into the Biological Roles of Artichoke Extracts: Implications in Intestinal, Cardiovascular, and Neurodegenerative Diseases

Insights into the Biological Roles of Artichoke Extracts: Implications in Intestinal, Cardiovascular, and Neurodegenerative Diseases

Hemin Ameliorates the Inflammatory Activity in the Inflammatory Bowel Disease: A Non-Clinical Study in Rodents

Functional and Therapeutic Potential of Cynara scolymus in Health Benefits

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