Effect of Cycloplegia on Optical Biometry in Pediatric Eyes

Raina, Usha K; Gupta, Shantanu; Gupta, Anika; Goray, Apurva; Saini, Varun

doi:10.3928/01913913-20180327-05

Cited by 12 publications

(15 citation statements)

References 23 publications

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“…Also, cycloplegia using 2% homatropine drops have been shown to reduce axial length measurements significantly in children between 5 and 15 years of age. 29 Possibly the use of cycloplegic drops therefore underestimates the true axial length values. As several studies described using cycloplegia for measuring refractive state, and others did not describe whether they used these drops, we decided not to distinguish between using cycloplegia or not.…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis of ocular axial length in newborns and infants up to 3 years of age

Groot

Lissenberg‐Witte

Rijn

et al. 2022

Survey of Ophthalmology

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show abstract

Section: Discussionmentioning

confidence: 99%

Meta-analysis of ocular axial length in newborns and infants up to 3 years of age

Groot

Lissenberg‐Witte

Rijn

et al. 2022

Survey of Ophthalmology

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show abstract

“…In this study, we examined the effects of highconcentration of atropine (1%) and tropicamide on ocular biological parameters in children, and calculated the changes of parameters before and after cycloplegia (difference value: post-cycloplegia minus pre-cycloplegia, absolute value of difference: |post-cycloplegia minus pre-cycloplegia|). In previous studies, some scholars had con rmed that cycloplegia in children could lead to changes in AL, K, CCT and ACD, among which the most studies on ACD increased observably [7,11,[13][14][15][16][18][19][20][21][22][23][24][25].…”

Section: Discussionmentioning

confidence: 99%

“…The ciliary paralysis reagents we used are mainly atropine as long-acting and tropicamide as short-acting. However, previous studies have shown that cycloplegia has a certain impact on ocular biological parameters, especially in children, including refractive state [10][11][12][13], axial length (AL) [11,[13][14][15][16], corneal curvature, axial position of corneal astigmatism, central corneal thickness (CCT) [10,[15][16][17][18][19],…”

Section: Introductionmentioning

confidence: 99%

Effects of Atropine and Tropicamide on Ocular Biological Parameters in Children: A Prospective Observational Study

Tao

Tan

Huang

et al. 2022

Preprint

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Background The effectiveness of cycloplegia in delaying the progression of myopia and its application in refractive examination in children have been extensively studied, but there are still few studies on the effects of atropine/tropicamide on ocular biological parameters. Therefore, the purpose of this study is to explore the effects of atropine/tropicamide on children's ocular biological parameters in different age groups, and the differences between them. Methods This was a prospective observational study in which all school children were examined for diopter and ocular biological parameters in the outpatient clinic, and 1% atropine and tropicamide were applied for the treatment. After examination, we enrolled the patients grouped by age (age from 2 to 12 years treated by atropine, 55 cases; age from 2 to 10 years treated by tropicamide, 70 cases; age from 14 to 17 years treated by tropicamide, 70 cases). The ocular biological parameters of each patient before and after cycloplegia were measured and the difference value and its absolute value were calculated for statistical analysis using independent-samples t-test. Results There was no significant difference in the difference value of ocular biological parameters and the absolute value of the difference in the same age groups before and after cycloplegia (P > 0.05). There were significant statistical differences in the corresponding values of AL, K1 and ACD among different age groups (P < 0.05). Before cycloplegia, there were significant differences in AL, K, K1, K2 and ACD in different age groups (P < 0.05). However, the differences in AL, K, K1, K2 and ACD among different age groups disappeared after cycloplegia (P > 0.05). Conclusions This study demonstrated that atropine/tropicamide have different effects on cycloplegia in children of different ages. The effects of atropine/tropicamide on ocular biological parameters should be fully taken into account when evaluating the refractive state before refractive surgery or calculating the degree of intraocular lens before cataract surgery.

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“…Raina UK et al used Lenstar LS900 to study the axial length of 56 normal children aged 5 to 15 years, and found that after 2% homatropine cycloplegia, the axial length of these children was signi cantly shortened compared with that before medication. 19 Unfortunately, the study did not focus on the refractive status of children. Tang XP et al 20 used optical coherence biometry to measure the eye axis of children aged 4 to 11 years, and found that the eye axis of the hyperopia group was signi cantly shortened after atropine cycloplegic treatment, while the myopia group did not change signi cantly, and similar research conclusions were also supported by Wang LH et al 21 If the above studies were conducted using different cycloplegic agents, Woodman EC et al used IOL Master to measure the effect of continuous 5D accommodation near work for 30 minutes on the axial length of adult myopes and emmetropes, and found that near accommodation could signi cantly increase their axial length.…”

Section: Pupil Diametermentioning

confidence: 99%

Effects of Cycloplegic Agents on Ocular Parameters in Children with Myopia and Hyperopia

Qu¹,

Liu²,

Gao³

et al. 2022

Preprint

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Background To study the effect of cycloplegia on ocular parameters in children with myopia and hyperopia. Methods Forty two myopia and forty four hyperopia eyes in children between 5 and 10 years of age were included. Measurements were taken before and after cycloplegia using 1% atropine sulfate ointment. The ocular parameters included central corneal thickness (CCT), corneal curvature (CC), anterior chamber depth (ACD), pupil diameter (PD), axial length (AL) and central retinal thickness (CRT). Results There was no significant difference in CCT, CC and CRT between the two groups without cycloplegia, but the ACD of myopia (3.64 ± 0.28mm) group was significantly higher than that of hyperopia (3.40 ± 0.24mm, t=-4.522, P < .0001). The average PD of myopia (4.85 ± 0.87mm) group was significantly smaller than that of hyperopia group (5.47 ± 1.15mm, t = 2.903, P < .0046). The average AL of myopia (24.25 ± 0.77mm) was significantly higher than that of hyperopia (21.73 ± 1.24mm, t = 12.084, P < .0001). However, it was found that the average PD of myopia (7.68 ± 0.51mm) was significantly larger than that of hyperopia (7.41 ± 0.57mm, t = 2.364, P = .0202) under cycloplegia. As for the changes of refractive factors before and after cycloplegia, Deepened ACD and enlarged PD was noted in both group after cycloplegia. Conclusions Cycloplegia not only affects ACD and PD, but also leads to the reversal of PD difference between the two groups. The cycloplegia effects enabled us to study changes in all known ocular parameters in a short period of time.

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Effect of Cycloplegia on Optical Biometry in Pediatric Eyes

Abstract: Biometry measurements have to be carefully interpreted in pediatric eyes where cycloplegia is an important part of the examination. [J Pediatr Ophthalmol Strabismus. 2018;55(4):260-265.].

Cited by 12 publications

References 23 publications

Meta-analysis of ocular axial length in newborns and infants up to 3 years of age

Meta-analysis of ocular axial length in newborns and infants up to 3 years of age

Effects of Atropine and Tropicamide on Ocular Biological Parameters in Children: A Prospective Observational Study

Effects of Cycloplegic Agents on Ocular Parameters in Children with Myopia and Hyperopia

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