Effect of curcumin on kidney histopathological changes, lipid peroxidation and total antioxidant capacity of serum in sodium arsenite-treated mice

Momeni, Hamid Reza; Eskandari, Najmeh

doi:10.1016/j.etp.2016.08.006

Cited by 45 publications

(30 citation statements)

References 24 publications

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“…In addition, an appropriate increase in the use of dose is also a conventional method. Curcumin (50 or 100 mg/kg BW) has been shown to attenuate diseases, EMT and tumor process in animal studies (Afrin et al, ; Goncalves Vde et al, ; Momeni and Eskandari, ; Nisari et al, ; Yuan et al, ). Studies from our laboratory have also suggested that 100 mg/kg BW curcumin restored tobacco smoke‐induced EMT in the mice stomach and bladder tissues.…”

Section: Discussionmentioning

confidence: 99%

Effects of Curcumin on Tobacco Smoke-induced Hepatic MAPK Pathway Activation and Epithelial-Mesenchymal TransitionIn Vivo

Liang

Xie

et al. 2017

Phytother. Res.

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Tobacco smoke is a major risk factor for hepatic cancer. Epithelial-mesenchymal transition (EMT) induced by tobacco smoke is crucially involved in the initiation and development of cancer. Mitogen-activated protein kinase (MAPK) pathways play important roles in tobacco smoke-associated carcinogenesis including EMT process. The chemopreventive effect of curcumin supplementation against cancers has been reported. In this study, we investigated the effects of tobacco smoke on MAPK pathway activation and EMT alterations, and then the preventive effect of curcumin was examined in the liver of BALB/c mice. Our results indicated that exposure of mice to tobacco smoke for 12 weeks led to activation of ERK1/2, JNK, p38 and ERK5 pathways as well as activator protein-1 (AP-1) proteins in liver tissue. Exposure of mice to tobacco smoke reduced the hepatic mRNA and protein expression of the epithelial markers, while the hepatic mRNA and protein levels of the mesenchymal markers were increased. Treatment of curcumin effectively attenuated tobacco smoke-induced activation of ERK1/2 and JNK MAPK pathways, AP-1 proteins and EMT alterations in the mice liver. Our data suggested the protective effect of curcumin in tobacco smoke-triggered MAPK pathway activation and EMT in the liver of BALB/c mice, thus providing new insights into the chemoprevention of tobacco smoke-associated hepatic cancer. Copyright © 2017 John Wiley & Sons, Ltd.

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Section: Discussionmentioning

confidence: 99%

Effects of Curcumin on Tobacco Smoke-induced Hepatic MAPK Pathway Activation and Epithelial-Mesenchymal TransitionIn Vivo

Liang

Xie

et al. 2017

Phytother. Res.

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“…A normal glomerulus indicated a normal organize appearance of glomerulus with a regular Bowman’s space. The abnormal glomerulus indicated a loss of integrity, atrophy, and increasing of Bowman’s space [ [19] , [20] ]. The deformation level of the glomerulus was focused on the capsular space and was classified into 20%, 40%, 60%, 80%, and 100% wider than the control.…”

Section: Methodsmentioning

confidence: 99%

Varied dose exposures to ultrafine particles in the motorcycle smoke cause kidney cell damages in male mice

2018

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“…The use of curcumin, a bioactive agent derived from Curcuma longa rhizomes, has been used in the treatment of humans and animals because of its innumerable benefits, particularly its antimicrobial (Sarkar, De, & Mukhopadhyay, 2016), antioxidant and lipid peroxidation-protecting properties (Akinyemi et al, 2017;Momeni & Eskandari, 2017), in addition to its promotion of growth and performance in animals (Dono, 2013;Jaguezeski et al, 2018). Only in recent years have there been studies evaluating curcumin as an additive in ruminant feed (Cervantes-Valencia, Alcalá-Canto, Sumano-Lopez, Ducoing-Watty, & Gutierrez-Olvera, 2016;Jaguezeski et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Low‐dose curcumin‐loaded Eudragit L‐100‐nanocapsules in the diet of dairy sheep increases antioxidant levels and reduces lipid peroxidation in milk

et al. 2019

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The main objective of this study was to evaluate whether the addition of curcumin‐loaded nanocapsules (prepared and characterized) in the diets of dairy sheep improved milk quality. The nanocapsules were prepared using two polymers: poly‐ε‐caprolactone (PCL) and Eudragit L‐100. The nanocapsules contained 0.25 mg/ml (Nano‐Eudragit L‐100) and 2 mg/ml (Nano‐PCL) of curcumin. Dairy sheep were divided into four groups: A (control), B (30 mg free curcumin/kg concentrate), C (3 mg Nano‐PCL/kg concentrate), and D (3 mg Nano‐Eudragit/kg concentrate). We observed that the number of total leukocytes and serum globulin levels were lower in Group D than in the control (Group A) (p < 0.05). Antioxidant capacity against peroxyl radicals (ACAP) and catalase enzymes was elevated in Group D, with consequently reduced lipid peroxidation (LPO; p < 0.05). In milk, there were no differences in production and composition between groups during the experimental period (p > 0.05); however, ACAP increased and LPO decreased in milk. Practical applications Curcumin is a functional molecule with potent antioxidant, anti‐inflammatory, and antimicrobial actions, used frequently and with medical indications in human food. Free curcumin in sheep diets improves milk quality and increases its shelf life. This study showed that curcumin nanocapsules produced from the Eudragit L‐100 polymer potentiated the anti‐inflammatory and antioxidant actions of dairy sheep when used in the diet daily, at doses 10 times lower than that of free curcumin. These positive effects were reflected in higher total antioxidant capacity and lower lipid peroxidation in milk in sheep‐fed curcumin‐loaded Eudragit L‐100 nanocapsules, generating desirable milk properties. In practice, the use of nanotechnology enhances the beneficial effects of curcumin in milk, possibly creating a nutraceutical food desirable to consumers.

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Effect of curcumin on kidney histopathological changes, lipid peroxidation and total antioxidant capacity of serum in sodium arsenite-treated mice

Cited by 45 publications

References 24 publications

Effects of Curcumin on Tobacco Smoke-induced Hepatic MAPK Pathway Activation and Epithelial-Mesenchymal TransitionIn Vivo

Effects of Curcumin on Tobacco Smoke-induced Hepatic MAPK Pathway Activation and Epithelial-Mesenchymal TransitionIn Vivo

Varied dose exposures to ultrafine particles in the motorcycle smoke cause kidney cell damages in male mice

Low‐dose curcumin‐loaded Eudragit L‐100‐nanocapsules in the diet of dairy sheep increases antioxidant levels and reduces lipid peroxidation in milk

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