Effect of curcumin and cosolvents on the micellization of Pluronic F127 in aqueous solution

Thapa, Raj Kumar; Cazzador, Flavio; Grønlien, Krister Gjestvang; Tønnesen, Hanne

doi:10.1016/j.colsurfb.2020.111250

Cited by 39 publications

(24 citation statements)

References 45 publications

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“…The main diameter of the empty micelles is 31.91 ± 4.4 nm, within the range of reported values[22]. The strong intensity signal at 6.88 nm is due to the presence of the polymeric macromolecules unassociated, in equilibrium with the micellar aggregates and the signal around 354 nm is probably due to some larger micelle-micelle aggregates, which have been reported in other papers[34]. The polydispersity index of 0.669 is consistent with a trimodal distribution.…”

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confidence: 88%

Mixed Pluronic—Cremophor Polymeric Micelles as Nanocarriers for Poorly Soluble Antibiotics—The Influence on the Antibacterial Activity

et al. 2021

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In this work, novel polymeric mixed micelles from Pluronic F127 and Cremophor EL were investigated as drug delivery systems for Norfloxacin as model antibiotic drug. The optimal molar ratio of surfactants was determined, in order to decrease critical micellar concentration (CMC) and prepare carriers with minimal surfactant concentrations. The particle size, zeta potential, and encapsulation efficiency were determined for both pure and mixed micelles with selected composition. In vitro release kinetics of Norfloxacin from micelles show that the composition of surfactant mixture generates tunable extended release. The mixed micelles exhibit good biocompatibility against normal fibroblasts MRC-5 cells, while some cytotoxicity was found in all micellar systems at high concentrations. The influence of the surfactant components in the carrier on the antibacterial properties of Norfloxacin was investigated. The drug loaded mixed micellar formulation exhibit good activity against clinical isolated strains, compared with the CLSI recommended standard strains (Staphylococcus aureus ATCC 25923, Enterococcus faecalis ATCC 29213, Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 25922). P. aeruginosa 5399 clinical strain shows low sensitivity to Norfloxacin in all tested micelle systems. The results suggest that Cremophor EL-Pluronic F127 mixed micelles can be considered as novel controlled release delivery systems for hydrophobic antimicrobial drugs.

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confidence: 88%

Mixed Pluronic—Cremophor Polymeric Micelles as Nanocarriers for Poorly Soluble Antibiotics—The Influence on the Antibacterial Activity

et al. 2021

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“…e UVvis absorption spectra were recorded in the range 350-450 nm [10] with a UV-2401PC spectrophotometer (Shimadzu, Kyoto, Japan).…”

Section: Characterization Of the Spray-dried Materialsmentioning

confidence: 99%

Controlled Release of Curcumin from HPMC (Hydroxypropyl Methyl Cellulose) Co-Spray-Dried Materials

Zheng

Wang

Xiang

et al. 2021

Bioinorganic Chemistry and Applications

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In order to achieve the controlled release of curcumin, HPMC (hydroxypropyl methyl cellulose) was spray dried with curcumin and lactose. The spray-dried materials were pressed into tablets with a diameter of 8 mm, and their release characteristics in vitro were measured. In vitro experiments showed that the release of curcumin from the HPMC mixture was significantly slower due to the sustained-release property of HPMC as a typical excipient. The release profile of curcumin from the HPMC mixture was relatively stable for a controlled release. SEM images show that the HPMC co-spray-dried powders have crumpled surfaces due to the large molecular weight of HPMC. DSC, XRD, FTIR, N2 adsorption, and TGA have been measured for the spray-dried curcumin materials. This work indicates that HPMC can be used as a controlled-release excipient for curcumin preparations.

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“…and CMC of 0.313 mM at 20 ºC) (Alexandridis, Holzwarthf, & Hatton, 1994) and Pluronics® F127 (MW ~12600 g mol −1 , PEO-70 %wt. and CMC of 0.56 mM at 25 ºC) (Thapa, Cazzador, Grønlien, & Tønnesen, 2020) were purchased from Sigma-Aldrich. Betaine hydrochloride (99%) was purchased from Alfa Aesar and used as-is for transesterification.…”

Section: Methodsmentioning

confidence: 99%

Synergetic effect of cationic starch (ether/ester) and Pluronics for improving inkjet printing quality of office papers

et al. 2021

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Improving the printability of paper is still a relevant challenge, despite the fast development of digital communications.While it is well-known that cationic starches enhance ink density, their commercial paper-grade forms are limited to ethers with low degree of substitution. This work addresses the underexplored potential of highly substituted cationic starch for paper coating and its combination with tri-block polymers, namely Pluronics (P123 and F127), taking advantage of their supramolecular interactions with amylose chains. For that purpose, cationic starch ether and ester (starch betainate), both with a degree of substitution of 0.3, were synthesized by alkaline etherification and by transesterification, respectively. Paper without any surface treatment was subjected to one-side bar coating with suspensions encompassing those products and Pluronics, besides other common components. Black, cyan, yellow and magenta inks were printed on all coated papers through an inkjet printer. Key properties of printing quality such as the gamut area, gamut volume, optical density, print-through, inter-color bleed and circularity were measured in a controlled temperature-humidity environment. For instance, a formulation with cationic starch (ether/ester) and P123 improved the gamut area by 16-18% in comparison to native starch-coated paper sheets. Interestingly, the individual assessment of each component showed that cationic starch ether, starch betainate and P123 only improved the gamut area by 5.6%, 8.9% and 6.8%, respectively. Finally, but not less importantly, starch betainate was found to quench optical brightening agents to a lesser extent than cationic starch ethers.

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Effect of curcumin and cosolvents on the micellization of Pluronic F127 in aqueous solution

Cited by 39 publications

References 45 publications

Mixed Pluronic—Cremophor Polymeric Micelles as Nanocarriers for Poorly Soluble Antibiotics—The Influence on the Antibacterial Activity

Mixed Pluronic—Cremophor Polymeric Micelles as Nanocarriers for Poorly Soluble Antibiotics—The Influence on the Antibacterial Activity

Controlled Release of Curcumin from HPMC (Hydroxypropyl Methyl Cellulose) Co-Spray-Dried Materials

Synergetic effect of cationic starch (ether/ester) and Pluronics for improving inkjet printing quality of office papers

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