Effect of Curcuma zedoaria crude extract against tumor progression and immunomodulation

Carvalho, F. De; Vassão, RC; Ma, Nicoletti; Maria, DA

doi:10.1590/s1678-91992010000200013

Cited by 17 publications

(18 citation statements)

References 30 publications

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“…Curcumin has long been known as a chemo-preventive and chemotherapeutic agent, and in vivo studies with curcumin have demonstrated decreased tumorigenesis in many organs [10], including antiproliferative effects in melanoma [11]. Because of its lack of toxicity, there has been increasing interest in further studies with curcumin [12,13].…”

Section: Introductionmentioning

confidence: 99%

The curcumin analog DM-1 induces apoptotic cell death in melanoma

et al. 2013

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SummaryThe main difficulty in the successful treatment of metastatic melanoma is that this type of cancer is known to be resistant to chemotherapy. Chemotherapy remains the treatment of choice and dacarbazine (DTIC) is the best standard treatment. The DM-1 compound is a curcumin analog that possesses several curcumin characteristics, such as antiproliferative, antitumor and antimetastatic properties. The objective of this study was to evaluate the signaling pathways involved in melanoma cell death after treatment with DM-1 compared to the standard agent for melanoma treatment, DTIC. Altogether, these data confirm DM-1 as a chemotherapeutic agent with effective tumor control properties and a lower incidence of side effects in normal cells compared to DTIC.

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Section: Introductionmentioning

confidence: 99%

The curcumin analog DM-1 induces apoptotic cell death in melanoma

et al. 2013

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“…A pre-clinical study was conducted using ethanolic extract of Curcuma zedoaria against B16F10 melanoma cell line revealed that the ethanolic extract returned decreased and increased levels of RBCs and WBCs respectively to the normal levels (Carvalho et al, 2010).…”

Section: Resultsmentioning

confidence: 99%

In vitro and in vivo evaluation of antitumor activity of methanolic extract of Argyreia nervosa leaves on Ehrlich ascites carcinoma

Sharma¹,

Dhamija²,

Kumar³

et al. 2015

Bangladesh J Pharmacol

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The herb of importance like Argyreia nervosa has shown wide range of pharmacological activities. Its methanolic extract of A. nervosa has been explored against Ehrlich ascites carcinoma (EAC) induced liquid and solid tumor in mice. Liquid and solid tumors were induced by intraperitoneal and subcutaneous transplantation of EAC cells in Balb/C mice. Significant and dose dependant results are observed when the mice are sacrificed on 15th day for estimation of tumor proliferation, hematological, biochemical and hepatic antioxidant parameters. Mean survival time (days) was increased to 36.5 from 20.5 extract treated mice. The extract also showed a decrease (p<0.001) in body weight and percentage reduction in tumor volume respectively when it was evaluated in solid tumor induced mice for a period of 30 days. From the result it was concluded that the extract has as a potent antitumor activity and that is comparable to 5-fluorouracil.

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“…Antitumor [66] Antibacterial/antimicrobial [58] Anti-amoebic activity [69] Anticancer activity [60,67,68] Hepatoprotective activity [70][71][72] Antivenom activity [73] C. angustifolia also known as Indian Arrowroot is an attractive ginger with stout underground rhizomes which lie dormant in winters.…”

Section: Curcuma Zedoariamentioning

confidence: 99%

An Overview of Medicinal Value of Curcuma Species

Kanase¹,

Khan²

2018

Asian J Pharm Clin Res

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Curcuma is a genus of about 100 accepted species in the family Zingiberaceae that contains such species as turmeric and Siam tulip. They are native to Southeast Asia, southern China, ISSN (Online): 2319-7064 ISSN (Online): 2319-7064 naturalized in other warm parts of the world such as Tropical Africa, Central America, Florida, and various islands of the Pacific, Indian, and Atlantic Oceans. Few known species of Curcuma with reported pharmacological activity are Curcuma longa, Curcuma aeruginosa, Curcuma pseudomontana, Curcuma aromatica, Curcuma xanthorrhiza, Curcuma zedoaria, Curcuma angustifolia. Among them, C. longa is the one species extensively studied and has ancient traditional medicinal uses. These Curcuma species have been used in traditional medicine as a household remedy for various diseases, including biliary disorders, anorexia, cough, diabetic wounds, hepatic disorders, rheumatism, and sinusitis. For the past few decades, extensive work has been done to establish the biological activities and pharmacological actions of Curcuma species and its extracts. This review article is created with an intention to give an overview on the reported research carried out on the Curcuma species such as anticancer activity, antitumor, antitubercular, antibacterial, antimicrobial, toxicity activity, and wound healing. And also, these Curcuma species can be considered as herbal medicinal plant having a plethora of research opportunities based on its traditional use and biological activity.

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Effect of Curcuma zedoaria crude extract against tumor progression and immunomodulation

Cited by 17 publications

References 30 publications

The curcumin analog DM-1 induces apoptotic cell death in melanoma

The curcumin analog DM-1 induces apoptotic cell death in melanoma

<i>In vitro</i> and <i>in vivo</i> evaluation of antitumor activity of methanolic extract of <i>Argyreia nervosa</i> leaves on Ehrlich ascites carcinoma

An Overview of Medicinal Value of Curcuma Species

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