Effect of Curcuma longa (Turmeric) Against Potassium Bromate-induced Cardiac Oxidative Damage, Hematological and Lipid Profile Alterations in Rats

Oladele, Johnson Olaleye; Oyeleke, Oyedotun M.; Awosanya, Olaide O.; Oladele, Oluwaseun Titilope

doi:10.3923/sjsres.2020.8.15

Cited by 7 publications

(8 citation statements)

References 28 publications

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“…C. longa extract also increased GSH, CAT, and ascorbic acid, but reduced MDA level in rats. 128 In doxorubicin-induced cardiotoxicity in rats, oral administration of the ethanolic or aqueous extract of C. longa (200 mg/kg) significantly reduced mortality, creatine kinase MB (Ck-MB) and lactate dehydrogenase (LDH)activities. The ethanolic and aqueous extracts of C. longa also significantly increased GSH and other antioxidant enzyme activities but significantly reduced serum NO and MDA levels.…”

Section: Antioxidant Effects Of C Longa Animal Studiesmentioning

confidence: 99%

Experimental and clinical reports on anti‐inflammatory, antioxidant, and immunomodulatory effects ofCurcuma longaand curcumin, an updated and comprehensive review

et al. 2021

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Curcuma longa (C. longa) or turmeric is a plant with a long history of use in traditional medicine, especially for treating inflammatory conditions C. longa and its main constituent, curcumin (CUR), showed various pharmacological effects such as antioxidant and anti-microbial properties. The updated knowledge of anti-inflammatory, antioxidant, and immunomodulatory effects of C. longa and CUR is provided in this review article. Pharmacological effects of C. longa, and CUR, including anti-inflammatory, antioxidant, and immunomodulatory properties, were searched using various databases and appropriate keywords until September 2020. Various studies showed anti-inflammatory effects of C. longa and CUR, including decreased white blood cell, neutrophil, and eosinophil numbers, and its protective effects on serum levels of inflammatory mediators such as phospholipase A2 and total protein in different inflammatory disorders. The antioxidant effects of C. longa and CUR were also reported in several studies. The plant extracts and CUR decreased

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Section: Antioxidant Effects Of C Longa Animal Studiesmentioning

confidence: 99%

Experimental and clinical reports on anti‐inflammatory, antioxidant, and immunomodulatory effects ofCurcuma longaand curcumin, an updated and comprehensive review

et al. 2021

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“…Thus, the need for natural anti-inflammatory agents with increased pharmacological response and no or lowest degree of adverse effects ( Bagad et al., 2013 ; Oladele et al., 2017 ) which is obtainable in medicinal plants. Curcuma longa (Turmeric) is one of such medicinal plant, the most essential metabolite of turmeric is curcumin and its responsible for its anti-inflammatory properties ( Jurenka, 2009 ; Oladele et al., 2020a ). Many clinical studies have been carried out to prove the anti-inflammatory effect of curcumin in diseases such as rheumatoid arthritis and reduced its clinical manifestation such as joint swelling and morning stiffness when compare with standard drug, phenylbutazone ( Deodhar et al., 1980 ).…”

Section: Medicinal Plants With Pharmacological and Biological Action mentioning

confidence: 99%

“…Consistent eating of dietary foods like fruits and vegetables is well documented to have potentials in the management of various chronic ailments affecting human in Africa. These supplements of antioxidant are directly being obtained from fresh fruits and vegetables, which contain a vast quantity of alkaloids, flavonoids and antioxidant complements which can take part in the defense mechanisms against different cardiovascular ailments including different types of cancers and many health problems ( Oladele et al., 2020a , b ; Ajayi et al., 2017 ).…”

Section: Medicinal Plants With Pharmacological and Biological Action mentioning

confidence: 99%

“…Turmeric is a medicinal plant of Curcuma longa which belongs to the Zingiberaceae family. It is popularly referred to as Atale or Ajo among the Yoruba speaking parts of Nigeria ( Priyadarini, 2014 ; Oladele et al., 2020a ). Turmeric is a perennial plant.…”

Section: Medicinal Plants With Pharmacological and Biological Action mentioning

confidence: 99%

“…The rhizomes of Curcuma longa plants are gathered each year either for propagation in the next season or for consumption. The rhizome of C. longa , Linn has been reported to have many therapeutic activities such as anti-inflammatory, anti-diabetic, hepatoprotective, hypolipidemic, anti-diarrhoeal, anti-asthmatic, and anti-cancerous drug ( Sastry, 2005 ; Sharma, 2006 ; Chunekar, 2010 ; Pandey, 2002 ; Oladele et al., 2020a ).…”

Section: Medicinal Plants With Pharmacological and Biological Action mentioning

confidence: 99%

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A systematic review on COVID-19 pandemic with special emphasis on curative potentials of Nigeria based medicinal plants

Oladele¹,

Ajayi

Oyeleke³

et al. 2020

Heliyon

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Despite the frightening mortality rate associated with COVID-19, there is no known approved drug to effectively combat the pandemic. COVID-19 clinical manifestations include fever, fatigue, cough, shortness of breath, and other complications. At present, there is no known effective treatment or vaccine that can mitigate/inhibit SARS-CoV-2. Available clinical intervention for COVID-19 is only palliative and limited to support. Thus, there is an exigent need for effective and non-invasive treatment. This article evaluates the possible mechanism of actions of SARS-CoV-2 and present Nigeria based medicinal plants which have pharmacological and biological activities that can mitigate the hallmarks of the pathogenesis of COVID-19. SARS-CoV-2 mode of actions includes hyper-inflammation characterized by a severe and fatal hyper-cytokinaemia with multi-organ failure; immunosuppression; reduction of angiotensin-converting enzyme 2 (ACE2) to enhance pulmonary vascular permeability causing damage to the alveoli; and further activated by open reading frame (ORF)3a, ORF3b, and ORF7a via c-Jun N- terminal kinase (JNK) pathway which induces lung damage. These mechanisms of action of SARS-CoV-2 can be mitigated by a combination therapy of medicinal herbs based on their pharmacological activities. Since the clinical manifestations of COVID-19 are multifactorial with co-morbidities, we strongly recommend the use of combined therapy such that two or more herbs with specific therapeutic actions are administered to combat the mediators of the disease.

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Tropical Food Spices: A Promising Panacea for the Novel Coronavirus Disease (COVID‐19)

Ademiluyi

Oyeniran

Oboh

2020

eFood

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Coronavirus disease 2019 (COVID-19) is an infectious fatal disease caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) with millions of individuals infected globally within few months of its outbreak. During infection, the SARS-CoV-2 main protease binds directly to Angiotensin-converting Enzyme 2 (ACE2) receptor of the human host cells, most especially in the lungs where it replicates and causes respiratory infections. Currently, there is neither universally recommended nor approved treatment for the morbid disease caused by this virus. Therefore, the urgent need for therapy has led to the use of medicinal plants such as tropical food spices which have been previously used as antivirals. Thus, this review described the coronaviruses, the causative virus of COVID-19, the role of ACE2 in SARS-CoV-2 infection, health complications in COVID-19, the general importance of tropical spices, the potential beneficial role of tropical spices as potent inhibitors of SARS-CoV-2 and the mechanisms of action of some selected tropical spices: turmeric, onion, garlic, red chille pepper, black pepper and cinnamon; based on prior knowledge of their medicinal values. This might help to promote the use of spices and/or their isolated compounds as functional foods, nutraceuticals and potent alternative medicines to provide fast optimal relief or cure for COVID-19.

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Effect of Curcuma longa (Turmeric) Against Potassium Bromate-induced Cardiac Oxidative Damage, Hematological and Lipid Profile Alterations in Rats

Cited by 7 publications

References 28 publications

Experimental and clinical reports on anti‐inflammatory, antioxidant, and immunomodulatory effects ofCurcuma longaand curcumin, an updated and comprehensive review

Experimental and clinical reports on anti‐inflammatory, antioxidant, and immunomodulatory effects ofCurcuma longaand curcumin, an updated and comprehensive review

A systematic review on COVID-19 pandemic with special emphasis on curative potentials of Nigeria based medicinal plants

Tropical Food Spices: A Promising Panacea for the Novel Coronavirus Disease (COVID‐19)

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