Effect of Curcuma longa Hot Water Extract on Activity of Neuronal Cells Related to Oxidative Stress

Abstract

The aim of this study is to screen a therapeutic agent with a cognitive function. The inhibitory effect of Curcuma longa hot water extract (CLWE) on the angiotension-converting enzyme and acetylcholinesterase derived from rabbit lungs and neural cells (PC12), as well as its antioxidant effect, was investigated in this study. Thus, for the first time, the direct scavenging effect of CLWE on DPPH radicals, superoxide anions, hydroxyl radicals, lipid peroxidation, reducing power, and the protective effect of DNA oxidation related to oxidative stress was evaluated in vitro. In addition, it was observed that CLWE especially exhibited a scavenging effect on reducing power and superoxide anions in this study. CLWE showed a protective effect on DNA oxidation produced by hydroxyl radicals. Furthermore, CLWE inhibited the activity of angiotensin-converting enzymes above 0.25%. Additionally, the extract inhibited oxidative stress and inducible nitric oxide in neuronal cells. Therefore, these results demonstrated that CLWE has antioxidant activity and neuronal cell protective effects, suggesting that it may have great potential as a natural source for human health.

Effect of balanced low pressure drying of curcuma longa leaf on skin immune activation activities

“…Turmeric (Curcuma longa) is a perennial plant of the ginger family, Zingiberaceae, and genus Curcuma [1,2]. Flower resembling small, thorn-like fine hair grows behind the leaves.…”

“…In galenic pharmacy where the effects of oriental medicines are listed, C. longa is known to have an excellent pain relief effect and enhances the blood circulation due to its warm characteristics. C. longa is traditionally used for treating inflammations in several countries [2]. Also, C. longa is known to have coloring effect due to curcuminoids and recently its bioactive and medicinal effect is recognized.…”