Effect of balanced low pressure drying of curcuma longa leaf on skin immune activation activities

Abstract

The effect of balanced low pressure drying pretreatment associated with ultrasonication extraction (BU) on the enhancement of skin immune modulatory activities of Curcuma longa leaf was studied by comparing with conventional hot air drying (HE), freeze drying (FE) and balanced low pressure drying (BE) pretreatment processes. In considering skin immune activation activities such as the inhibition of hyaluronidase activity, the BU extract showed ca. 10% higher than those of HE, and even higher than that of the FE extract. Nitric oxide production from macrophage of the BU extract in adding 1.0 mg/mL was increased up to 16.5 µM. When measuring inhibition of IL-6 and TNF-α production from the human T lymphocytes (T cell), the BU extract also showed 53% and 78% of inhibition effect, respectively. It is found that the BU extract could effectively suppress the expression levels of skin inflammation related genes such as Cox-2 and iNOS, down to 80% and 85% compared to the control, respectively. Balanced low pressure drying process was especially active on dehydration of the leaves with minimizing the destruction and making easier elution of the bioactive substances, which resulted in higher extraction yield and better biological activities.

Effect of heat and microwave treatments on phenolic compounds and fatty acids of turmeric (Curcuma longa L.) and saffron (Crocus sativus L.)

“…Concerning this, heat-related chemical reactions involved in domestic cooking might compromise or alter these bioactive compounds and their properties. Curcuminoids, as examples, are susceptible to long drying time, high temperature, extraction, processing, and storage (Suresh et al, 2007;Choi et al, 2014). However, heat treatments exert controversial changes in crocin and safranal concentrations (Gregory et al, 2005;Sánchez et al, 2008;Rodríguez-Neira et al, 2014).…”

Photoprotection and Antiaging Activity of Extracts from Honeybush (Cyclopia sp.)—In Vitro Wound Healing and Inhibition of the Skin Extracellular Matrix Enzymes: Tyrosinase, Collagenase, Elastase and Hyaluronidase

“…Sunscreens sourced from nature, especially from the group of polyphenols, are in demand. Some plant extracts and antioxidant compounds, such as curcumin and quercetin, have anti-inflammatory activity via hyaluronidase inhibition and may limit the inflammation process around sunburnt or wounded skin [ 39 , 42 ].…”