Chemical constituents and biological research on plants in the genus<i>Curcuma</i>

Sun, Wenyue; Wang, Sheng; Zhao, Wenwen; Wu, Chun‐Ming; Guo, Shuhui; Gao, Hongwei; Tao, Hongxun; Lu, Jin‐Jian; Wang, Ying; Chen, Xiuping

doi:10.1080/10408398.2016.1176554

Cited by 92 publications

(50 citation statements)

References 491 publications

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“…Diphenylalkaloids are alkaloids with one or more diphenyl ether linkages [72]. Diphenylalkaloids can be further classified, depending on the length of the carbon chain between two aromatic rings, into diphenylheptanoids, diphenylpentanoids, and other diphenylalkanoids [73]. Refer to Fig.…”

Section: Phenolic Compoundsmentioning

confidence: 99%

Delivery of natural phenolic compounds for the potential treatment of lung cancer

et al. 2019

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The application of natural products to treat various diseases, such as cancer, has been an important area of research for many years. Several phytochemicals have demonstrated anticarcinogenic activity to prevent or reduce the progression of cancer by modulating various cellular mechanisms. However, poor bioavailability has hindered clinical success and the incorporation of these drugs into efficient drug delivery systems would be beneficial. For lung cancer, local delivery via the pulmonary route would also be more effective. In this article, recent in vitro scientific literature on phenolic compounds with anticancer activity towards lung cancer cell lines is reviewed and nanoparticulate delivery is mentioned as a possible solution to the problem of bioavailability. The first part of the review will explore the different classes of natural phenolic compounds and discuss recent reports on their activity on lung cancer cells. Then, the problem of the poor bioavailability of phenolic compounds will be explored, followed by a summary of recent advances in improving the efficacy of these phenolic compounds using nanoparticulate drug delivery systems. Graphical abstract The rationale for direct delivery of phenolic compounds loaded in microparticles to the lungs

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Section: Phenolic Compoundsmentioning

confidence: 99%

Delivery of natural phenolic compounds for the potential treatment of lung cancer

et al. 2019

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“…P value of ≤0.05 was considered statistically significant. 9,10-dimethoxypterocarpan, luteolin, emodin-3-methyl ether, 5-O-caffeoyl quinic acid methyl ester, 3-hydroxy-9,10dimethoxyptercarpan, curcumenol, atractylenolide III, 2atractylenolide, isorhamnetin, astraisoflavanglucoside-6″-Omalonate, ononin, 3b-O-acetyl ursolic acid, 3b-O-acetyl oleanolic acid, and seco isolariciresinol 9-O -b -Dglucopyranoside by comparing the fragment ions with those of characteristic components of the herbal preparation reported in literatures (Lin et al, 2000;Doshi et al, 2016;Sun et al, 2017;Zhu et al, 2018) (Table 3).…”

Section: Discussionmentioning

confidence: 99%

A Chinese Herbal Formula Suppresses Colorectal Cancer Migration and Vasculogenic Mimicry Through ROS/HIF-1α/MMP2 Pathway in Hypoxic Microenvironment

Zong

Tang

et al. 2020

Front. Pharmacol.

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Various malignant tumors, including colorectal cancer, have the ability to form functional blood vessels for tumor growth and metastasis. Vasculogenic mimicry (VM) refers to the ability of highly invasive tumor cells to link each other to form vessels, which is associated with poor cancer prognosis. However, the antitumor VM agents are still lacking in the clinic. Astragalus Atractylodes mixture (AAM), a traditional Chinese medicine, has shown to inhibit VM formation; however the exact mechanism is not completely clarified. In this study, we found that HCT-116 and LoVo could form a VM network. Additionally, hypoxia increases the intracellular reactive oxygen species (ROS) level and accelerates migration, VM formation in colorectal cancer cells, while N-Acetylcysteine (NAC) could reverse these phenomena. Notably, further mechanical exploration confirmed that the matrix metalloprotease 2 (MMP2) induction is ROS dependent under hypoxic condition. On the basis, we found that AAM could effectively inhibit hypoxia-induced ROS generation, migration, VM formation as well as HIF-1a and MMP2 expression. In vivo, AAM significantly inhibits metastasis of colorectal cancer in murine lung-metastasis model. Taken together, these results verified that AAM effectively inhibits migration and VM formation by suppressing ROS/HIF-1a/MMP2 pathway in colorectal cancer under hypoxic condition, suggesting AAM could serve as a therapeutic agent to inhibit VM formation in human colorectal cancer.

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“…Curcumol, a bioactive sesquiterpenoid, has been isolated from numerous plants of family Zingiberaceae. These plants are mostly found in Southeast Asia, China, Indonesia, India, Peru, and West Indies [19]. Curcuma, the most important genus of the family Zingiberaceae, encompasses approximately 100 species.…”

Section: Curcumol and Its Natural Sourcesmentioning

confidence: 99%

Curcumol: From Plant Roots to Cancer Roots

et al. 2019

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Natural products, an infinite treasure of bioactive scaffolds, have provided an excellent reservoir for the discovery of drugs since millennium. These naturally occurring, biologically active and therapeutically effective chemical entities have emerged as novel paradigm for the prevention of various diseases. This review aims to give an update on the sources as well as pharmacological profile of curcumol, a pharmacologically active sesquiterpenoid, which is an imperative bioactive constituent of several plants mainly from genus Curcuma. Curcumol has potential to fight against cancer, oxidative stress, neurodegeneration, microbial infections, and inflammation. Curcumol has been documented as potent inducer of apoptosis in numerous cancer cells via targeting key signaling pathways as MAPK/ERK, PI3K/Akt and NF-κB which are generally deregulated in several cancers. The reported data reveals multitarget activity of curcumol in cancer treatment suggesting its importance as anticancer drug in future. It is speculated that curcumol may provide an excellent opportunity for the cure of cancer but further investigations on mechanism of its action and preclinical trials are still mandatory to further validate the potential of this natural cancer killer in anticancer therapies.

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Chemical constituents and biological research on plants in the genusCurcuma

Cited by 92 publications

References 491 publications

Delivery of natural phenolic compounds for the potential treatment of lung cancer

Delivery of natural phenolic compounds for the potential treatment of lung cancer

A Chinese Herbal Formula Suppresses Colorectal Cancer Migration and Vasculogenic Mimicry Through ROS/HIF-1α/MMP2 Pathway in Hypoxic Microenvironment

Curcumol: From Plant Roots to Cancer Roots

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