Effect of crystallization of caffeic acid enhanced stability and dual biological efficacy

Khan, Shamsuddin Sultan; Iqbal, Muhammad Adnan; Majid, Amin Malik Shah Abdul

doi:10.1080/23312025.2016.1243460

Cited by 5 publications

(1 citation statement)

References 14 publications

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“…In addition to direct application, scholars synthesized a series of dimers from caffeic acid and ferulic acid, and found that they could effectively remove DPPH and strongly inhibit the self-induced aggregation of Aβ (1-42) (He et al, 2017). In contrast, the prepared crystalline caffeic acid also showed neuroprotective effect as well as biological effects on AD on R28 cell line with the addition amount less than 6 μg/mL (Khan et al, 2016).…”

Section: Caffeic Acidmentioning

confidence: 99%

Update on new trends and progress of natural active ingredients in the intervention of Alzheimer's disease, based on understanding of traditional Chinese and Western relevant theories: A review

Rang

Liu

et al. 2023

Phytotherapy Research

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Alzheimer's disease (AD) is one of the major neurological disorders causing death in the elderly worldwide. As a neurodegenerative disease that is difficult to prevent and cure, the pathogenesis of AD is complex and there is no effective cure. A variety of natural products derived from plants have been reported to have promising anti‐AD activities, including flavonoids, terpenes, phenolic acids and alkaloids, which can effectively relieve the symptoms of AD in a variety of ways. This paper mainly reviews the pharmacological activity and mechanisms of natural products against AD. Although the clinical efficacy of these plants still needs to be determined by further high‐quality studies, it may also provide a basis for future researchers to study anti‐AD in depth.

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Section: Caffeic Acidmentioning

confidence: 99%

Update on new trends and progress of natural active ingredients in the intervention of Alzheimer's disease, based on understanding of traditional Chinese and Western relevant theories: A review

Rang

Liu

et al. 2023

Phytotherapy Research

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Design and evaluation of microencapsulated systems containing extract of whole green coffee fruit rich in phenolic acids

et al. 2020

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Chemical profiling of Thevetia peruviana leaves cytotoxic active extracts enhanced by microemulsion formulation

et al. 2020

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Background: Natural products played an essential role as a complementary cytotoxic agent avoiding complications of other therapies. In phytoformulation research, herbal drugs of nano-size have attracted more attention for more bioavailability and less active dose. We aim in this work to introduce new non-mutagenic cytotoxic agent from Thevetia peruviana leaves extracts and potentiate the activity by loading upon microemulsion formulations as an advanced mode of drug delivery system. Results: Thevetia peruviana toxicity test revealed its safety (LD 50 = 3.083 g/kg). In vivo genotoxicity tests measuring chromosomal aberrations were done to prove non-mutagenicity of the plant for both somatic and germ cells. The plant showed antioxidant activity with 121.215, 128.925, and 120.098 mg/g extract, calculated as Trolox equivalent (TE/g) for DPPH, ABTS, and FRAP assays, respectively. Successive extracts of the plant were incorporated in microemulsion formulations (MEF) and characterized for their electrical conductivity, poly-dispersity index, and in vitro drug release action. Cytotoxic activity of successive extracts was investigated against breast MCF7 and liver HEPG2 carcinoma cell lines before and after loading upon MEs. Enhancement in activity was detected for both pet. ether and ethanol MEFs, as IC 50 of pet. ether extract decreased from 25 to 6.5 μg/ml against MCF7 cell line, while ethanol formulation recorded IC 50 = 3.58 μg/ml against HEPG2 cell line after showing no activity of the extract at the tested concentrations. Regarding metabolites of polar fraction, total ethanol extract was estimated for total phenolic and flavonoid contents to record 47.7941 mg GAE/g calculated as gallic acid equivalent and 32.7667 mg CE/g measured as catechin equivalent, respectively. HPLC analysis for polar fraction recorded twelve compounds identified according to the available authentics with rutin the major flavonoid (7.33 mg/g) and rosmarinic acid (13.48 mg/g) the most abundant phenolic acid. Phytoconstituents of non-polar fraction were investigated after saponification of pet. ether extract using GC/MS analysis revealed the identification of 88.02% of the total unsaponifiable matter and 89.17 % of the total saponifiable matter. Conclusion: Thevetia peruviana is a safe cytotoxic agent. Microemulsion formulations of active extracts potentiate the cytotoxic actions against HEPG2 and MCF7 cell lines with better bioavailability and less medicinal doses.

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Effect of crystallization of caffeic acid enhanced stability and dual biological efficacy

Cited by 5 publications

References 14 publications

Update on new trends and progress of natural active ingredients in the intervention of Alzheimer's disease, based on understanding of traditional Chinese and Western relevant theories: A review

Update on new trends and progress of natural active ingredients in the intervention of Alzheimer's disease, based on understanding of traditional Chinese and Western relevant theories: A review

Design and evaluation of microencapsulated systems containing extract of whole green coffee fruit rich in phenolic acids

Chemical profiling of Thevetia peruviana leaves cytotoxic active extracts enhanced by microemulsion formulation

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