Effect of Cryoprecipitate on Liver Regeneration in Cirrhosis

Черноусов, А. Ф.; Хоробрых, Т В; Karpova, R.V.; Zenkova, K.I.

doi:10.18484/2305-0047.2017.4.350

Cited by 4 publications

(3 citation statements)

References 2 publications

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“…It has been proven that cryoprecipitate has not only hemostatic but also local and systemic anti-inflammatory and immunomodulatory effects due to pro-and antiinflammatory cytokines in its composition (spontaneous interferon, interleukin-2, interleukin-8, plasminogen, albumin, globulin fraction etc.) (11). Fibrin glue that was injected into the abscess cavity also has a local immunomodulatory effect (12).…”

Section: Discussionmentioning

confidence: 99%

Ultrasound-Guided Percutaneous Drainage of Abdominal Abscess in a Patient With Crohn's Disease: A Case Report

et al. 2021

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Introduction: The autoimmune process in Crohn's disease exacerbates destructive changes in the intestinal wall and leads to complications such as bleeding (21. 9%), strictures (21.6%), and abscesses (19.7%).Case Presentation: The case of a 32-year-old male patient with an 8-year history of Crohn's disease is presented. He was admitted for emergency indications with severe pain in the right lower quadrant, chills, and a fever reaching 39.0°C. The patient had anemia, hypocoagulation and immunodeficiency. Ultrasound and CT scans of the abdominal organs revealed an abscess in the right iliac region. It was immediately drained under ultrasound control and X-ray. A fistulogram showed the fistula between the abscess and the ileum. Routine antibiotic therapy selected in accordance with the sensitivity of the microflora and sanitization of the abscess cavity were not effective. The immunomodulatory therapy, intravenous administration of cryoprecipitate, and the introduction of fibrin glue into the abscess cavity were added to the treatment. After the treatment, the patient's immune status corresponded to normal, the abscess healed, and the fistula was closed.Conclusion: In patients suffering from Crohn's disease with the formation of an abscess and a long-term non-healing intestinal fistula, it is essential that the diagnostic algorithm includes the examination of the immune status. Treatment should include immunomodulators, intravenous administration of cryoprecipitate. To close the fistula in these patients, it is advisable to use fibrin glue that has a local immunomodulatory effect.

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Section: Discussionmentioning

confidence: 99%

Ultrasound-Guided Percutaneous Drainage of Abdominal Abscess in a Patient With Crohn's Disease: A Case Report

et al. 2021

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“…Fibrin glue has been proven to contain pro- and anti-inflammatory cytokines, growth factors that contribute to tissue regeneration in the area of its injection [4,[10], [11], [12]]. It has been proven both in the experiment and in the clinic that fibrin glue supports tissue regeneration saving the physiological ratio of the parenchyma and stroma, without proliferation of connective tissue [13].…”

Section: Discussionmentioning

confidence: 99%

Percutaneous drainage under the control of ultrasound of the left-sided subphrenic abscess after gastrectomy: A case report

Karpova

Kirakosyan

Хоробрых

et al. 2019

Annals of Medicine and Surgery

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IntroductionAbdominal abscesses are one of the frequent and dangerous postoperative complication. They occur as a result of failure of seams esophagojejunal anastomosis after gastrectomy (17%), perforation of gastric and duodenal ulcers (26.8%), splenectomy (25.4%), failure of biliodigestive anastomoses (23.8%), inadequate drainage of the subphrenic space (22.2%), acute pancreatitis (14%). Left-sided subphrenic abscesses are the most common of them.Case presentationWe present a patient with the left-sided subphrenic abscess, formed as a result of insolvency of the esophagojejunal anastomosis after gastrectomy and splenectomy, which underwent percutaneous drainage under the control of ultrasound and X-ray. Sanitation of the abscess cavity and the introduction of fibrin glue into it made it possible to close the fistula and heal the patient.DiscussionThe described case shows that the rehabilitation of the abscess and the injection of fibrin glue into it, made it possible to avoid surgery, eliminate the abscess and close the connection with the esophagojejunal anastomosis in a short time.ConclusionPercutaneous drainage under the control of ultrasound made it possible to avoid surgery and heal the patient with the left-sided subphrenic abscess in a short time. Fistula treatment with fibrin glue is not only effective, but is also less risky than surgery.

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“…This arranged regeneration, with the formation of sinusoids, decreases portal hypertension. 5 However, there are no studies described in the literature devoted to degenerative processes in the small and large intestine walls after stimulation of liver regeneration with cryoprecipitate.…”

Section: Introductionmentioning

confidence: 99%

<p>Increases in Autoantibody Level Associated with Degenerative Changes in the Intestinal Mucosa in Liver Cirrhosis</p>

Karpova¹,

Russkova²,

Lavrentieva³

2020

CEG

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Background: Portal hypertensive colonopathy is a consequence of portal hypertension that develops in hepatic cirrhosis. Pathological processes occurring in intestinal epithelium cells can be revealed by changes in the autoantibody titers to intestinal antigens. It is important both in diagnosis and in the evaluation of the treatment effectiveness. Purpose: To investigate the effect of portal hypertension in patients with liver cirrhosis on degenerative processes in the walls of the small and large intestines after stimulation of liver regeneration with cryoprecipitate. Methods: Thirty-six patients with liver cirrhosis underwent a procedure for percutaneous introduction of cryoprecipitate into the liver tissue. Before and 1 year after it, all the patients were measured for portal blood flow parameters, performed colonoscopy with biopsy, and determined autoantibodies to intestinal antigens (ItM, SCM) in the blood. Comparative analyses of changes in the large intestine mucosa before and after reducing portal hypertension by stimulating liver regeneration with cryoprecipitate were conducted. Results: Here, we show that the degenerative process in the mucosa of the intestines increases, despite the positive dynamics of portal blood flow parameters after the liver regeneration. Autoantibodies values for the intestine antigens were higher than normal in 22 of the 36 patients after 1 year of introduction of cryoprecipitate into the liver. Morphological analysis of the intestinal wall showed the presence of edema/mucosal atrophy and neutrophilic/lymphocytic-histiocytic infiltration in 28 of the 36 patients. Conclusion: Changes in autoantibodies to intestinal antigens are an informative method for diagnosing colonopathy and enteropathy at early stages, providing the possibility to administer proper timely treatment. Patients with hepatic cirrhosis are recommended to have their intestinal microflora tested and be administered drugs that improve their composition.

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Effect of Cryoprecipitate on Liver Regeneration in Cirrhosis

Cited by 4 publications

References 2 publications

Ultrasound-Guided Percutaneous Drainage of Abdominal Abscess in a Patient With Crohn's Disease: A Case Report

Ultrasound-Guided Percutaneous Drainage of Abdominal Abscess in a Patient With Crohn's Disease: A Case Report

Percutaneous drainage under the control of ultrasound of the left-sided subphrenic abscess after gastrectomy: A case report

<p>Increases in Autoantibody Level Associated with Degenerative Changes in the Intestinal Mucosa in Liver Cirrhosis</p>

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