Effect of crosslinking procedure on structural, thermal, and functional performances of cellulosic nanofibers: A comparison between chemical and photochemical crosslinking

Khorshidi, Sajedeh; Solouk, Atefeh; Karkhaneh, Akbar; Mirzadeh, Hamid; Sharifi, Shahriar; Mazinani, Saeedeh

doi:10.1002/app.43832

Cited by 18 publications

(9 citation statements)

References 24 publications

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“…Cell morphology showed the cells' survival and growth on all of the sample surfaces, which confirms no toxicity and biocompatibility of the PET material. Compared with the PET sheet, all fibrous substrates showed more cellular attachment and spreading based on the fact that more surface area of NFs can increase the number of reactive absorbed proteins on the surface providing more binding sites for cell receptors …”

Section: Resultsmentioning

confidence: 99%

Electrospun polyethylene terephthalate (PET) nanofibrous conduit for biomedical application

Jafari

Salekdeh

Solouk

et al. 2019

Polymers for Advanced Techs

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Nanostructured biomaterials have great potential in the field of biomedical engineering. Efforts for treatment of cardiovascular diseases focused on introducing vascular substitutes that are nonthrombogenic and have long-term patency, but still there is not any perfect replacement for clinical use. In this study, nanostructure tubes of a commonly known biocompatible polymer, polyethylene terephthalate (PET), were prepared via electrospinning process using small diameter mandrel as a collector with two different speeds. The nanofibers (NFs) morphologies' physical and mechanical properties were investigated according to scanning electron microscope (SEM), water contact angle (WCA), porosity measurement, differential scanning calorimetry (DSC), and tensile test. Finer NFs, more percentage of crystallinity, and superior mechanical properties were observed for samples prepared by higher speed mandrel. Since both samples stimulated platelet adhesion and activation, further surface modification with sodium nitrate as nitric oxide (NO) donor was done using two different approaches: dip-coating and electrospraying. The modified NFs were evaluated via SEM, WCA, tensile test, platelets, and cell adhesion. The results showed more hydrophilicity, reduction in platelet adhesion, and improved blood compatibility for eNO-HS (electrosprayed NO for higher collector speed) compared with other samples implying the promising potential of this fabrication and modification technique for improving PET-based cardiovascular substitutes.

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Section: Resultsmentioning

confidence: 99%

Electrospun polyethylene terephthalate (PET) nanofibrous conduit for biomedical application

Jafari

Salekdeh

Solouk

et al. 2019

Polymers for Advanced Techs

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“…There is still much scope to further tune the physical properties of chitosan‐gelatin‐hyaluronic hybrid scaffolds to improve the ability of these biomaterials to better regenerate tissues. Some key physical properties of scaffolds that can be fine‐tuned include pore morphology, molecular mobility, as well as mechanical and scaffold/water interaction . Pore morphology is particularly important as it affects cell behavior including proliferation and differentiation.…”

Section: Introductionmentioning

confidence: 99%

Synergistic effects of crosslinking and chitosan molecular weight on the microstructure, molecular mobility, thermal and sorption properties of porous chitosan/gelatin/hyaluronic acid scaffolds

Acevedo

Sánchez

Díaz-Calderón

et al. 2017

J of Applied Polymer Sci

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In this study, synergistic effects of crosslinking and chitosan molecular weight on the microstructure, molecular mobility, thermal, and sorption properties of porous chitosan/gelatin/hyaluronic acid hybrid foams are reported. Fourier transform infrared spectroscopy has been utilized to confirm the covalent attachment of hyaluronic acid to gelatin and chitosan, and covalent chemical crosslinking between gelatin and chitosan. Detailed image analysis of scanning electron microscopy images of the porous scaffold hydrids reveal that the pore size of the materials formulated using either low-or high-molecular-weight chitosan increases significantly upon crosslinking using ethyl(dimethylaminopropyl) carbodiimide/N-Hydroxysuccinimide. These microstructural changes are even more pronounced for the crosslinked hybrid scaffolds formulated using low-molecular-weight chitosan, highlighting a synergistic effect between crosslinking and the use of low-molecular-weight chitosan. Results obtained using differential scanning calorimetry demonstrate a significant reduction in molecular mobility reduction in molecular mobility for crosslinked scaffolds formed using high-molecular-weight chitosan compared to non-crosslinked hybrids and crosslinked hybrids formulated using low-molecular-weight chitosan. Correspondingly, dynamic vapor sorption evidenced significantly lower water vapor sorption for crosslinked scaffolds formulated using high-molecular-weight chitosan.

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“…The former was related to water evaporation and the later was T g of the hydrogel. The appearance of a single T g corroborated that two polymeric components were fully miscible . The miscibility of oxidized pectin and fibroin was also verified by calculating Hansen solubility parameters.…”

Section: Resultsmentioning

confidence: 57%

High‐strength functionalized pectin/fibroin hydrogel with tunable properties: A structure–property relationship study

Khorshidi

Karkhaneh

Bonakdar

et al. 2019

J of Applied Polymer Sci

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Hydrogels possessing high mechanical strength and well-controlled properties are of utmost interest in bone tissue engineering. In the current study, a strong self-crosslinked hydrogel with variable properties has been developed from a combinatory composition of functionalized pectin and silk fibroin. Pectin chains underwent partial oxidation to be decorated with aldehyde functionalities. Later on, functionalized polysaccharide and protein were blended with different ratios, and corresponding variations in crystalline structure as well as in morphological, mechanical, and rheological properties have been monitored. Some theories have been used to better perceive the relation between blending ratio and hydrogel properties. Avrami equation based on time sweep rheological analysis elucidated that in sample with equivalent ratio of oxidized pectin and fibroin, the crystallization was highly delayed due to dominance of Schiff's base reaction. The Herschel-Bulkley model based on flow curve rheology test corroborated that aforesaid composition revealed the most noticeable shear thinning behavior and accordingly the strongest crosslinked network. Finally, rubber elastic theory based on dynamic mechanical analysis implied that said formulation possessed the highest crosslinking density due to higher availability of aldehyde to amine functionalities. Moreover, cell culture studies proved that P50 F50 sample prevailed over other compositions with respect to cell viability and function.

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Effect of crosslinking procedure on structural, thermal, and functional performances of cellulosic nanofibers: A comparison between chemical and photochemical crosslinking

Cited by 18 publications

References 24 publications

Electrospun polyethylene terephthalate (PET) nanofibrous conduit for biomedical application

Electrospun polyethylene terephthalate (PET) nanofibrous conduit for biomedical application

Synergistic effects of crosslinking and chitosan molecular weight on the microstructure, molecular mobility, thermal and sorption properties of porous chitosan/gelatin/hyaluronic acid scaffolds

High‐strength functionalized pectin/fibroin hydrogel with tunable properties: A structure–property relationship study

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