Emesis gravidarum is a common complaint of nausea and vomitting that felt by almost 90% of pregnant women. Emesis gravidarum, or better known as morning sickness, offen occur on first trimester of pregnancy. It bring on decrease quality of life pregnant women. It effects to physical and psychological health in pregnancy, family and social life, also their occupation. Etiology of emesis gravidarum is multifactors. This research aim is to analyze relationship between Beta HCG hormone level, anxiety and stress with severe degrees of emesis gravidarum on first trimester of pregnancy. Research used case control studied on 44 pregnant women on first trimester of pregnancy, each group was paired according to their gestational age. Research result show that there is a significant relationship between Beta HCG hormone level (p<0.001; OR 63.3; 95% CI 9.509-421.822) and anxiety (p<0.05; OR 4.9; 95% CI 1.325-18.205) with severe degrees of emesis gravidarum. Characteristic and demographics not entirely related to emesis gravidarum. Conclusion of this research is psychological and hormonal factors are related to severe degrees of emesis gravidarum. Dominant factors that caused severe degrees emesis gravidarum are multigravida and Beta HCG hormone levels in excess more than 49950 mui/dL.