Effect of Cortisone on Mast Cell Tumors (Mastocytoma) of the Dog

Bloom, Frank

doi:10.3181/00379727-79-19475

Cited by 86 publications

(12 citation statements)

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“…Al¬ though they may be dormant for months or years, lesions commonly enlarge rapidly and in rare instances they metastasize wide-]v 81,83 Because of its marked similarity to other round cell tumors, special stains are used to demonstrate cytoplasmic granules which are not always evident in less differentiated, more malignant tumors. We have had good results with the toluidine blue stain (Fig 11), a technique easily executed but not as Fig 10.-Basal cell epithelioma.…”

Section: General Comments On Animal Neoplasmsmentioning

confidence: 99%

Oral Disease in Man and Animals

Gorlin¹

1967

Arch Dermatol

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Section: General Comments On Animal Neoplasmsmentioning

confidence: 99%

Oral Disease in Man and Animals

Gorlin¹

1967

Arch Dermatol

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“…Finding (1)(2)(3) of changes in number and cytology of tissue mast cells after administration of adrenworticotropic hormone ( lAICTH) and cortisone has suggested that the pituitaryadrenal system exerts a controlling influence on the mast cell. The present paper describes attempts to explore this possibility further.…”

Section: Influence Of Hypophysis and Adrenal Cortex Upon Tissuementioning

confidence: 99%

Influence of Hypophysis and Adrenal Cortex upon Tissue Mast Cell of the Rat

Smith¹,

Lewis²

1954

Experimental Biology and Medicine

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Finding( 1-3) of changes in number and cytology of tissue mast cells after administration of adrenworticotropic hormone ( lAICTH) and cortisone has suggested that the pituitaryadrenal system exerts a controlling influence on the mast cell. The present paper describes attempts to explore this possibility further.Methods. Examinations of the behavior of tissue mast cell were made in whole mounts (4) of skin and mesentery of young adult, male Sprague-Dawley rats (20'0 g) at various times after adrenlalectomy, hypophysectomy and treatment with X-irradiation, ACTH, adrenal cortical extract, desoxycorticosterone acetate or cortisone. Adrenalectomized rats and their controls were allowed to drink only 1 a/o NaCl solution; hypophysectomized anim l s and their controls were confined to 20% sucrose solution. In addistion to regular diet of Rockland checkers, the hypophysectomid animals had access to oranges, lettuce, bread, and ground meat. Tissues were fixed in alcohol and stained with toluidine blue, as previously described (4). Tissues from intact or mock-operated controls were simultaneously studied. The radiation factors were 250 kv, 15 ma, 0.5 mm Cu and 3.0 mm Bakelite filters, 26.7 cm target distance, 1.5 mm Cu half-value layer and 215-225 r per minute. Mast cell counts were made on stained tissues, separate note taken of normal cells and atypical cells, i.e. degenerated cells with vacuoles and clumped granules(4,S). On a single slide from each animal, thirty contiguous fields, 0.0676 mm2 each, were counted at a magnification factor of 264.The only change in mast cells which could be identified with certainty was an increase in number of cells showing vacuolation and conglomeration of cytoplasmic granules. The allteratims were similar to those previously found by us in irradiated animals (4) and by others in aged tissue cultures of Results.*With assistance of Sally T. Hartig.mast cells ( 6) , edematous tissue and stimulated urticaria pigmentosa lesions ( 7), and after treatment with toluidine blue( 8), nitrogen mustard (9), ACTH ( 1 ) and cortisone ( 1,2 ) .In none of the present studies were there statistically significant changes in total mast cell number.Adrenalectomy was without influence upun the mast cell or upon its response to X-irradiation. Groups of 3 to 101 rats were examined at 2, 7, 14, 21, 28 and 316 days after a d r e n a b 'tomy. Number of cells countedr2.028 mm2 of skin varied between 404 land 6 10 in adrenalectomized and 458 and 608 in mock-operated animals. The per cent of abnormal cells was approximately the same in both groups of animals (.2 to 1.2% of all cells). At 2 weeks after adrenalectomy or mock-operation rats were subjected to single, total-body exposures to 600 r. Groups of 3 rats were examined at various intervals after irradiation. Number of cells counted/2.028 mm2 of skin varied between 328 and 676 in adrenalectomized, irradiated land 339 and 8316 in mock-operated, irradiated rats. The per cent of abnormal cells was 10, 33.3,33.6, 7.0, 3.4 and 2.9 in the adrenalectomized and 10.1, 42...

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“…Die Hcparinacmie, welche von einigen Autoren (1, 4) nachgewiesen werden konnte, wurde von anderen (12 15) nicht bestätigt. Ob gleich allgemein angenommen wird, daß die Mastzellen Heparin enthalten, konnte bei experimentell hervorgerufenem massivem Zerfall der Mastzellen kein freies Heparin nachgewiesen werden (16,17). Wir haben schon früher auf Grund des morphologischen Studiums der Mastzellen angenommen, daß die Heparinsekretion (18), sowie die Sekretion des Histamins und der Mukopolysaccha ride vom Hyaluronattypus (19) durch spezifische Sekretionsvorgängc gekennzeichnet ist.…”

Section: Q Uantitative Und Qualitative V Eränderungen Derunclassified

Quantitative und qualitative Veränderungen der Milz-Mastzellen röntgenbestrahlter Mäuse

Hill¹,

Praslička²

1958

Acta Haematol

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Effect of Cortisone on Mast Cell Tumors (Mastocytoma) of the Dog

Cited by 86 publications

References 0 publications

Oral Disease in Man and Animals

Oral Disease in Man and Animals

Influence of Hypophysis and Adrenal Cortex upon Tissue Mast Cell of the Rat

Quantitative und qualitative Veränderungen der Milz-Mastzellen röntgenbestrahlter Mäuse

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