Effect of Cortisone and Corticotropin on Prognosis of Systemic Lupus Erythematosus

Systemic Lupus Erythematosus Presenting with Sulphonamide Hypersensitivity Reaction

“…Treatment with cortisone or corticotrophin (A.C.T.H.) is the first measure which has been shown to exert a significant effect on the course of the disease, though it is less certain how it affects the ultimate prognosis (Carey et al, 1950;Soffer et al, 1950Soffer et al, , 1952Soffer et al, , 1954Haserick et al, 1951;Dubois et al, 1952;Johnson and Meyer, 1952;Shearn and Pirofsky, 1952;Haserick, 1953;Harvey et al, 1954).…”

“…Acquired auto-immune haemolytic anaemia (Michael et al, 1951 ;Dubois, 1952), associated with circulating antibody and a positive Coombs test, and thrombocytopenic purpura (Michael et al, 1951 ;Conley, 1952;Harvey et al, 1954) occur in a proportion of cases of S.L.E. The occurrence of increased plasma gamma-globulin (Coburn and Moore, 1943;Flynn, 1954) and biological false-positive reactions-for example, in serum tests for syphilis (Haserick and Long, 1952)-also suggests a disturbance of antibody production. Some patients with S.L.E.…”