Systemic Lupus Erythematosus Presenting with Sulphonamide Hypersensitivity Reaction

Lupus erythematosus cell phenomenon in patients with chronic ulcerative colitis

“…Chronic ulcerative colitis, particularly when accompanied by liver disease, may in itself be a clue to the existence of that susceptibility (lupus diathesis). That drug therapy, including sulphonamides and particularly hydralazine, may elicit the clinical manifestations of systemic lupus erythematosus in the susceptible individual is well documented in the literature (Gold, 1951;Honey, 1956;Domz, McNamara, and Holzapfel, 1959;Comens, 1961;Rallison, O'Brien, and Good, 1961;Alarcon-Segovia, Worthington, Ward, and Wakim, 1965). On the other hand, drug reactions are so frequent in patients with systemic lupus erythromatosus that they are often considered to have significant diagnostic importance.…”

Drug-induced lupus

“…В настоящее время сформировалась точка зрения, что связь между этими ЛС и ЛВ маловероятна, а клинические ситуации скорее демонстрировали дебют СКВ. Также не исключалось, что инфекционный процесс, послуживший основанием для назначения антибиотиков, мог явиться триггером идиопатической СКВ [6,7]. В 1953 г. опубликовано сообщение о развитии ЛВ на фоне приема гидралазина, а в 1957 г.…”

The Clinical Presentation of Systemic Lupus Erythematosus

“…Many lupus patients are also known to have increased allergies by some early reports [25] to a variety of agents, especially sulfur. Sulfur-containing drugs should be avoided where possible in patients with SLE.…”