Effect of Corticosteroid Therapy on Low-Molecular–Weight Protein Markers of Kidney Function

Bökenkamp, Arend; Laarman, Céleste A.R.C.; Braam, Katja I.; Wijk, J. A. E. van; Kors, Wijnanda A.; Kool, Marijke; Valk, Janneke de; Bouman, A.; Spreeuwenberg, Marieke; Stoffel‐Wagner, Birgit

doi:10.1373/clinchem.2007.094946

Cited by 51 publications

(29 citation statements)

References 5 publications

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“…Also, an in vitro experiment supported this, as a dosedependent corticosteroid-induced increase in the transcription of the CysC gene was demonstrated [85]. As a result, GFR estimated by CysC level in children was underestimated when compared with inulin clearance [83]. This finding was confirmed in an adult renal transplant population, where the increase in CysC was associated with a systematic underestimation of GFR [86].…”

Section: Cystatin Cmentioning

confidence: 83%

“…Cardiovascular disease is uncommon in children, though elevated CRP levels due to infection are not. However, Randers et al showed that CysC is not an acute phase reactant, as there was no association between elevated CRP and CysC in children with infections [82] Corticosteroid therapy Studies of both adults and children suggest that treatment with corticosteroids may influence the level of CysC in a likely dose-dependent manner [83,84]. Also, an in vitro experiment supported this, as a dosedependent corticosteroid-induced increase in the transcription of the CysC gene was demonstrated [85].…”

Section: Cystatin Cmentioning

confidence: 99%

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Measuring glomerular filtration rate in children; can cystatin C replace established methods? A review

et al. 2009

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Our aim was to evaluate published methods that use serum cystatin C (s-CysC) for measuring glomerular filtration rate (GFR) in children and to discuss advantages and limitations of s-CysC and of established GFR methods. A comprehensive literature review of clinical studies in children evaluating s-CysC or CysC-based formulas and plasma creatinine or creatinine-based formulas against an exogenous reference method using receiver operating characteristics (ROC) curves or Bland-Altman plots is presented. The comparison of s-CysC with plasma creatinine indicated that s-CysC was superior to plasma creatinine in five of 13 studies; four studies showed no difference, and, in four studies, no statistical comparison was made. Comparison of s-CysC and the Schwartz formula showed that s-CysC was superior to the Schwartz formula in two of seven studies; two studies demonstrated no difference, and, in one study, the Schwartz formula was superior to s-CysC. In two studies no statistical comparison was made. The CysC-based prediction equations all had high accuracy but low agreement when compared with a reference GFR, in the range of 30-40% at best. S-CysC is most likely superior to plasma creatinine and at least equal to creatinine-based formulas. CysC-based prediction equations are at least as good as creatinine-based formulas but cannot replace exogenous methods.

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Section: Cystatin Cmentioning

confidence: 83%

Section: Cystatin Cmentioning

confidence: 99%

Measuring glomerular filtration rate in children; can cystatin C replace established methods? A review

et al. 2009

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“…Although all 5 dogs with congestive heart failure were categorized as ISACHC class 2, many cases with a more severe class are needed to assess the effect of this disorder on the serum Cys-C concentration. Several human studies have shown that the serum Cys-C concentration is increased in hypothyroidism and after the administration of glucocorticoid, and is decreased in hyperthyroidism [4,24], although the effects of these hormones on the serum Cys-C concentration are unknown in animals. The present study also could not show the effects of these hormones, because all 174 dogs did not have the endocrine disease, or were not treated with glucocorticoid.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Measurement of Serum Cystatin C by an Enzyme-Linked Immunosorbent Assay for Humans as a Marker of the Glomerular Filtration Rate in Dogs

Miyagawa

Takemura

Hirose

2009

The Journal of Veterinary Medical Science

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ABSTRACT. The serum cystatin C (Cys-C) concentration is a better filtration marker than plasma creatinine (Cre) concentration in humans. In veterinary medicine, a few studies have shown that the serum Cys-C concentration in dogs is also a better marker than the plasma Cre concentration. The purpose of this study is to evaluate the applicability of measuring the serum Cys-C concentration by an enzymelinked immunosorbent assay (ELISA) as a marker of the glomerular filtration rate in dogs with various renal dysfunctions. The serum Cys-C concentration in dogs with chronic kidney disease (CKD) was significantly higher (1.23  0.21 mg/L) than that in 76 control dogs (0.85  0.15) (P<0.001). The reference range of the serum Cys-C concentrations in samples from the 76 control dogs was 0.55-1.15 mg/l. Serum Cys-C concentration was more strongly correlated with plasma iohexol clearance (r=-0.704, P<0.001) than plasma Cre concentration in dogs (r=-0.598, P<0.001). In a receiver operating characteristics analysis, significant differences between the serum Cys-C and plasma Cre concentrations were found with regard to their AUC (0.949, [SE, 0.019] and 0.849 [SE, 0.029]) and diagnostic sensitivity (90.3% and 73.6%) for detecting decreased PCio (P<0.05). Therefore, the measurement of serum Cys-C concentration by ELISA is more useful for the detection of early CKD than measuring the plasma Cre concentration.KEY WORDS: chronic kidney disease, cystatin C, glomerular filtration rate.

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“…Patients participated in the KIMONO study (7), a large cohort study in children with an SFK or underwent GFR measurement on the basis of clinical indications (time span of cohort assembly, May 2005-May 2012). Patients with a renal transplant and those who used glucocorticosteroids were excluded because of potential interactions with cystatin C metabolism (26).…”

Section: Study Patientsmentioning

confidence: 99%

Precision of Estimating Equations for GFR in Children with a Solitary Functioning Kidney

Westland

Abraham

Bökenkamp

et al. 2013

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objective Children with a solitary functioning kidney may develop CKD. Although widely used, equations to estimate GFR are not validated in these patients. This study sought to determine the precision of common estimating equations in the KIMONO (KIdney of MONofunctional Origin) cohort. Results The eGFR-CKiD2 equation performed best in children with a solitary functioning kidney (mean bias, 20.9 ml/min per 1.73 m 2 ; 95% and 54% of values within 630% and 610% of GFR-inulin, respectively). Mean bias for eGFR-Schwartz was 0.4 ml/min per 1.73 m 2 , with 90% and 33% of values within 630% and 610% of GFR-inulin, respectively. For all estimates, misclassification in K/DOQI stage ranged from 22% (eGFR-Zappitelli1) to 44% (urinary creatinine clearance) of children.Conclusions Use of a combined serum cystatin C/creatinine-based equation (eGFR-CKiD2) is recommended to monitor renal function in children with a solitary functioning kidney. When cystatin C is not routinely available, eGFR-Schwartz should be used. Misclassification in K/DOQI-stage remains a caveat for all equations.

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Effect of Corticosteroid Therapy on Low-Molecular–Weight Protein Markers of Kidney Function

Cited by 51 publications

References 5 publications

Measuring glomerular filtration rate in children; can cystatin C replace established methods? A review

Measuring glomerular filtration rate in children; can cystatin C replace established methods? A review

Evaluation of the Measurement of Serum Cystatin C by an Enzyme-Linked Immunosorbent Assay for Humans as a Marker of the Glomerular Filtration Rate in Dogs

Precision of Estimating Equations for GFR in Children with a Solitary Functioning Kidney

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