Effect of corosolic acid on postchallenge plasma glucose levels

Fukushima, Mitsuo; Matsuyama, Futoshi; Ueda, Naoya; Egawa, Katsuya; Takemoto, Jon Y.; Kajimoto, Yoshitaka; Yonaha, N.; Miura, Toshihiro; Kaneko, Tetsuo; Nishi, Yuichi; Mitsui, Rie; Fujita, Yoshihito; Yamada, Yoshio; Seino, Yutaka

doi:10.1016/j.diabres.2006.01.010

Cited by 96 publications

(82 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1), a compound which prevents oxidative stress, inflammation, hypertension and so on ( 1 ). The hypoglycemic effect of CA has been reported by various experiments (2)(3)(4)(5). The decrease in insulin resistance due to the increase in GLUT4 translocation has been reported as a mechanism of action ( 6 ).…”

mentioning

confidence: 99%

Effect of Corosolic Acid on the Hydrolysis of Disaccharides

Takagi

Miura

Ishibashi

et al. 2008

J Nutr Sci Vitaminol

View full text Add to dashboard Cite

SummaryThe banaba leaf ( Lagerstroemia speciosa L.) has been used in traditional Oriental medicine to treat diabetes in the Philippines. It contains corosolic acid (CA), a compound which has a hypoglycemic effect. We examined the effect of CA on blood glucose levels and the hydrolysis of disaccharides in the small intestine in mice. CA (10 mg/kg body weight) improved hyperglycemia after an oral administration of sucrose, and significantly reduced the hydrolysis of sucrose in the small intestine. These results suggest that the hypoglycemic activity of CA is derived, at least in part, due to the inhibition of the hydrolysis of sucrose.

show abstract

mentioning

confidence: 99%

Effect of Corosolic Acid on the Hydrolysis of Disaccharides

Takagi

Miura

Ishibashi

et al. 2008

J Nutr Sci Vitaminol

View full text Add to dashboard Cite

show abstract

“…11,12) CRA displays anti-diabetic activities in some animal experiments and clinical trials, while anti-diabetic drugs can affect cancer in experimental systems and in epidemiological studies. 13,14) CRA also has anti-tumor properties against several human cancer cells, 15,16) but the mechanisms for this anti-cancer activity in HER2 overexpressed gastric cancer have not yet been explored.…”

mentioning

confidence: 99%

Down-Regulation of Human Epidermal Growth Factor Receptor 2/neu Oncogene by Corosolic Acid Induces Cell Cycle Arrest and Apoptosis in NCI-N87 Human Gastric Cancer Cells

Lee

Young

Thương

et al. 2010

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

“…This anti-oxidant effect results from elevated serum glucose. Corosolic acid helps to reduced blood glucose level by activating the transport of glucose across the cell membranes, in short, corosolic acid has insulin-like effect (Liu et al, 2001;Miura et al, 2006;Fukushima et al, 2006). Table II showed that oral administration of extract significantly increased (31.3%, p<0.02) the depressed blood glutathione (a tripeptide of glycine, cystein and glutamic acid, GSH) level of chemically induced diabetic rats.…”

Section: Resultsmentioning

confidence: 87%

Hypoglycemic activity of Lagerstroemia speciosa L. extract on streptozotocin-induced diabetic rat: Underlying mechanism of action

Saha

Bhuiyan

Mazumder

et al. 2009

Bangladesh J Pharmacol

View full text Add to dashboard Cite

The hypoglycemic effect of Lagerstroemia speciosa L. leaves hot water extract on chemically induced diabetes in rat was investigated. Experimental result showed that, streptozotocin significantly (p<0.001) elevated the normal blood sugar level whereas treatment with hot water extract depressed the streptozotocin-induced high blood sugar level about 43.2% as compare to diabetic controls. Treatment with hot water extract increased the activity of shunt enzyme glucose-6-phosphate dehydrogenase (33.8%) and glutathione level (31.3%) and depression of the activity of hepatic gluconeogenic enzymes glucose-6-phasphatase (31.6%) and fructose-1,6-bisphosphatase (27.4%). These studies thus strongly suggest that the hot water extract of L. speciosa leave attributed its prominent hypoglycemic activity on experimental diabetic rats through suppression of gluconeogenesis and stimulation of glucose oxidation using the pentose phosphate pathway.

show abstract

Effect of corosolic acid on postchallenge plasma glucose levels

Cited by 96 publications

References 20 publications

Effect of Corosolic Acid on the Hydrolysis of Disaccharides

Effect of Corosolic Acid on the Hydrolysis of Disaccharides

Down-Regulation of Human Epidermal Growth Factor Receptor 2/neu Oncogene by Corosolic Acid Induces Cell Cycle Arrest and Apoptosis in NCI-N87 Human Gastric Cancer Cells

Hypoglycemic activity of Lagerstroemia speciosa L. extract on streptozotocin-induced diabetic rat: Underlying mechanism of action

Contact Info

Product

Resources

About