Effect of Coronavirus Disease (COVID-19) on Human Semen: No Evidence of Coronavirus in Semen of Patients

Vahidi, Serajoddin; Nabi, Ali; Alipoor, Hojat; Karami, Hormoz; Rahavian, Amirhossein; Ayatollahi, Alireza; Marvast, Laleh Dehghan; Abouei, Saeid

doi:10.1155/2022/6204880

Cited by 3 publications

(5 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, Pazir et al [27] reported that there were no significant differences in semen parameters before and after COVID-19 in terms of semen volume, sperm concentration, and progressive motility. Likewise, in a recent study by Vahidi et al [30], the semen analyses between patients in the acute and clinical recovery stages showed no significant differences between the two groups in semen count or motility parameters. Additionally, in their retrospective study, Wang et al [31] studied the semen parameters for male partners in couples undergoing in vitro fertilization cycles in a hospital in Wuhan, China, between May 2020 and February 2021.…”

Section: Discussionmentioning

confidence: 73%

COVID-19 and Semen Fluid Parameters, a Retrospective Study from Infertility Clinics

Al‐Alami

Albeitawi

ALNatsheh

et al. 2022

Life

View full text Add to dashboard Cite

The study of the effects of SARS-CoV-2 infection and/or vaccination on semen fluid analysis (SFA) parameters is still incomplete. The aim of this study is to assess the effect of COVID-19 infection and vaccination on sperm parameters for a sample of individuals visiting multi-infertility clinics in Jordan. SFA records were collected retrospectively between September and November 2021 and analyzed using Jamovi software (version 2.2.5 for Windows); p-values < 0.05 were considered statistically significant. Sperm concentration, progressive motility, normal morphology, and semen liquefaction time, volume, and viscosity were compared among two data categories. In the first category of data, SFA records from 354 participants were separated into four groups: only vaccinated, infected and vaccinated, neither infected nor vaccinated, and only infected. In the other category, SFA from 49 subjects before their infection and/or vaccination and after were classified into the same mentioned groups and analyzed. There were no statistically significant differences between the studied parameters in the SFA records in the first data category and the second. Nevertheless, the sperm concentration was higher among vaccinated subjects compared to unvaccinated ones (p = 0.04). It is concluded that SARS-CoV-2 infection and vaccines have no negative effects on SFA parameters.

show abstract

Section: Discussionmentioning

confidence: 73%

COVID-19 and Semen Fluid Parameters, a Retrospective Study from Infertility Clinics

Al‐Alami

Albeitawi

ALNatsheh

et al. 2022

Life

View full text Add to dashboard Cite

show abstract

“…Li et al (2020a) tried to answer this question using RT-PCR assay to detect SARS-CoV-2 in semen. Semen testing showed that 6/38 patients (15.8%) had positive results for SARS-CoV-2, including 4/15 patients (26.7%) who were in the acute stage of infection and 2/23 patients (8.7%) who were Twelve other studies (Holtmann et al 2020;Best et al 2021;Burke et al 2021;Gupta et al 2021;Guo et al 2021a;Ma et al 2021;Ruan et al 2021;Scroppo et al 2021;Temiz et al 2021;Dipankar et al 2022;Donders et al 2022;Vahidi et al 2022) could not detect SARS-CoV-2 virus in semen samples. For example, Ma et al (2021) used qRT-PCR to detect the SARS-CoV-2 virus in semen samples receiving negative results for all 12 male study participants.…”

Section: Resultsmentioning

confidence: 86%

“…There was no RNA detected in any participant's semen. Twenty men in the acute stage and 20 men in the clinical recovery stage were examined and all tested SARS-CoV-2 negative (Vahidi et al 2022). Some (Scroppo et al 2021) divided their study participants into two groups (mild and moderate COVID-19 disease), where SARS-CoV-2 had not been detected in any semen samples, while others (Holtmann et al 2020) did not detect SARS-CoV-2 RNA in semen samples from either recovered (n = 18) or acute infected (n = 2) subjects in the investigated time after the end of symptoms of 32.7 days on average using RT-PCR.…”

Section: Exclusion: Men With Other Acutementioning

confidence: 99%

“…At the time of diagnosis of COVID-19, semen parameters showed a significant decrease in percentage of total motility, percentage of progressive motility, semen volume, and sperm morphology (Koç and Kesero ˘ was significant difference in glu 2021). There no motility, concentration, or sperm count according to Vahidi et al (2022), who compared men in the acute stage to men in the clinical recovery. However, a significant difference in the morphology and viability parameters could be observed (lower in men with acute disease).…”

Section: Exclusion: Men With Other Acutementioning

confidence: 99%

See 1 more Smart Citation

Impact of COVID-19 disease on the male factor in reproductive medicine – how-to advise couples undergoing IVF/ICSI

Stark,

Kuster,

Hungerbühler

2024

Reprod. Fertil. Dev.

View full text Add to dashboard Cite

Context The COVID-19 pandemic has caused widespread concern about its potential impact on various aspects of human health. Aims This narrative review aims to summarise the current knowledge about the impact of COVID-19 on sperm quality and its effect on assisted reproductive technology. Methods In this narrative review, a literature search using the PubMed and MEDLINE databases was conducted to identify relevant original research articles published up to 29 January 2023. Results Thirty original studies were included in our review. There is evidence that SARS-CoV-2 is detectable in seminal fluid during the acute phase of infection and for up to 1 month. However, the fact that SARS-CoV-2 is barely detectable in semen makes sexual transmission very unlikely. COVID-19 infection has been associated with the following changes in sperm quality: morphology, altered motility, changed DNA fragmentation-index (DFI), decreased sperm concentration, lower total number of sperm, and a significant increase in leukocytes and cytokines. The effects mostly seem to be reversible and have not been shown to negatively affect the outcome of assisted reproductive technology but should lead to further research concerning the health of the offspring, because a correlation of increased DFI after COVID-19 even 5 months after disease could be assumed. Conclusions The findings of this narrative review suggest that SARS-CoV-2 may harm sperm quality in the acute phase. Implications A recovery time of at least 3 months regarding assisted reproductive therapy could be reasonable.

show abstract

“…The presence of the virus in the male reproductive tissue of two men with erectile dysfunction (ED) and other infected patients has been confirmed in past studies (Kresch et al, 2021;Vahidi et al, 2022). As the testis is one of the organs with high levels of constitutive expression of ACE2, the virus could directly damage testicular tissues (Chen et al, 2020;Wang & Xu, 2020).…”

Section: Introductionmentioning

confidence: 85%

Effect of COVID-19 On the Sexual Activity of Men

Abedinzadeh,

Vahidi,

Rahavian

et al. 2023

Am J Mens Health

Self Cite

View full text Add to dashboard Cite

In December 2019, severe acute respiratory syndrome COVID-19 was found in China. This virus can affect different organs depending on the coronavirus receptors on the cell surface, which allows the organ to be attacked by the coronavirus. Psychological distress and impaired pulmonary hemodynamics seem to be the cause of decreasing libido or sexual dysfunction after contracting COVID-19. This study was performed to assess the effect of coronavirus on the sexual activity of men. We enrolled 200 men with COVID-19, confirmed by an oropharyngeal sample, who had recovered from the coronavirus for 3 months. These men filled out the International Index of Erectile Function 5 (IIEF-5) questionnaire for their current and previous sexual status. Then, according to their IIEF-5 score, sexual activity before and after corona infection was compared. The mean age of the participants was 31.5 ±3.2 years. This study showed a significant difference between the IIEF-5 mean scores before and after COVID-19, which were 20.4 and 18.6, respectively ( p = .000). The condition of 56.1% of the patients did not change; however, coronavirus did have a negative effect on 39.6% of the patients. 4.1% of patients reported improvement in sexual performance. 45% of the patients reported no erectile dysfunction (ED) before contracting the coronavirus; while only 27.7% reported no ED after getting COVID-19. Our findings show that COVID-19 could influence the sexual activity of infected men, who also showed a higher ED prevalence after COVID-19 infection; however, hormonal assessment should be observed in the follow-up.

show abstract

Effect of Coronavirus Disease (COVID-19) on Human Semen: No Evidence of Coronavirus in Semen of Patients

Cited by 3 publications

References 19 publications

COVID-19 and Semen Fluid Parameters, a Retrospective Study from Infertility Clinics

COVID-19 and Semen Fluid Parameters, a Retrospective Study from Infertility Clinics

Impact of COVID-19 disease on the male factor in reproductive medicine – how-to advise couples undergoing IVF/ICSI

Effect of COVID-19 On the Sexual Activity of Men

Contact Info

Product

Resources

About