Effect of Copper Deficiency on Blood Lipid Profile and Haematological Parameters in Broilers

Abstract

The aim of the study was to observe the changes in haematological parameters and blood lipid profile through copper (Cu) deficiency. Eighty broiler chicks were used in the study. The chicks were separated into two equal groups (n = 40), feed treatment according to the groups started on day 7. The animals in the control group were fed with normal feed. Those in the Cu-deficient group were fed with feed that did not contain supplemental Cu. Blood samples were taken from all the animals on days 7, 21 and 49. Fibrinogen and prothrombin time were assayed in plasma; total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol (LDL-cholesterol), triglyceride and ceruloplasmin were assayed in sera; and haematocrit and thrombocyte levels were assayed in the blood samples. Total cholesterol, triglyceride and LDL-cholesterol levels were significantly higher in the Cu-deficient group than in the control group. Serum ceruloplasmin levels were lower in the Cu-deficient group than in the control group. Prothrombin time was higher in the Cu-deficient group than in the control group. Haematocrit levels were lower in the Cu-deficient group than in the control group. It was concluded that Cu deficiency created hypertriglyceridaemia, hypercholesterolaemia, insufficient growth and anaemia in broilers.

The effect of copper level in the diet on the distribution, and biological and immunological responses in a rat model

“…This is another proof that the deficit of Cu in the rat diet may negatively affect the body by weakening the antioxidant defence. Also, low level of Cu in the diet may adversely affect lipid metabolism and lead to an increase in the TG, TC or LDL levels in serum (Kaya et al, 2006;Burkhead and Lutsenko, 2013;Megahed et al, 2014). However, the results of our research do not confirm these reports.…”

Growth rate, metabolic parameters and carcass quality in turkeys fed diets with different inclusion levels and sources of supplemental copper

“…The above could partly explain the results of the present study where total plasma cholesterol concentration was the highest in turkeys fed diets with the lowest dose of supplemental Cu. Similar findings were reported by Kaya et al (2006) who observed symptoms of hypertriglyceridemia, hypercholesterolemia and anaemia in chickens fed diets deficient in Cu (3.5 mg Cu/kg in feed ingredients) relative to birds fed diets containing 8 mg Cu/kg.…”

Wilson Disease: Epigenetic effects of choline supplementation on phenotype and clinical course in a mouse model

“…3 In addition, PCA can cause copper deficiency in wild type mice with related changes in methionine and lipid metabolism. [36][37][38][39][40] Also, this study did not explore the role of choline beyond methyl donation. Choline contributes to mitochondrial membrane integrity 41 and can reduce lipid peroxidation, 42 which may have contributed to the observed phenotypic effects.…”