The effect of copper level in the diet on the distribution,
and biological and immunological responses in a rat model

Cholewińska, Ewelina; Fotschki, Bartosz; Juśkiewicz, Jerzy; Rusinek-Prystupa, Elżbieta; Ognik, Katarzyna

doi:10.22358/jafs/99893/2018

Cited by 5 publications

(3 citation statements)

References 42 publications

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“…According to Berta et al [35] and Cholewińska et al [36], increasing dietary supplementation with an element does not always increase its accumulation in all tissues proportionately because the excess can be absorbed and excreted. In addition, in response to reduced supplementation of minerals relative to the demand, the body may develop an adaptive mechanism (e.g., increased mobilization of transport proteins) to increase the deposition of selected minerals in the tissues [37,38]. Therefore, our results do not confirm those of El-Husseiny et al [28], Aksu et al [23], and Gajula et al [39], who found that reducing the addition of Cu, Zn, and Mn to the chicken diet reduces the content of these minerals (especially Zn and Mn) in the organ tissues and bones.…”

Section: Discussionmentioning

confidence: 99%

Effect of Different Levels and Sources of Dietary Copper, Zinc and Manganese on the Performance and Immune and Redox Status of Turkeys

Jankowski

Ognik

Kozłowski

et al. 2019

Animals

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The aim of the study was to determine the effectiveness of the combined use of Cu, Zn, and Mn nanoparticles in the diet of turkeys with regard to potential reduction of the levels of these elements added to feed. The experiment was carried out on turkeys’ hens assigned to four groups. Turkeys from the PC group received feed with the addition of inorganic forms of Cu, Zn, and Mn in the B.U.T. (British United Turkeys) recommended levels, from group IR received the addition in amounts reduced to 10% of the recommended levels, and from group NR received the addition of elements in the form of nanoparticles in the same amounts as in group IR. The turkeys from group NC received feed without the addition of these elements. The research showed that the addition of Cu, Zn, and Mn to turkey diets, in both inorganic forms and as nanoparticles, in quantities covering only 10% of B.U.T. recommendations had no adverse effect on growth performance or on the antioxidant and immune defense of turkeys. The changes in the redox status of the turkeys whose diet was not supplemented with Cu, Zn, and Mn indicate reduced oxidation processes in the tissues.

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Section: Discussionmentioning

confidence: 99%

Effect of Different Levels and Sources of Dietary Copper, Zinc and Manganese on the Performance and Immune and Redox Status of Turkeys

Jankowski

Ognik

Kozłowski

et al. 2019

Animals

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“…participate in the transport of metals, fatty acids, cholesterol and bile, and regulate osmotic pressure. Albumins are also effective antioxidants in plasma whose components are highly exposed to reactive oxygen species [ 43 ]. It should be noted that also in other experiments, diets containing insect meals and other animal protein sources such as fishmeal had no influence on most serum biochemical parameters in rabbits [ 13 , 26 , 44 ].…”

Section: Discussionmentioning

confidence: 99%

The effect of dietary supplementation with silkworm pupae meal on gastrointestinal function, nitrogen retention and blood biochemical parameters in rabbits

et al. 2021

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Background The aim of this study was to determine the effect of dietary inclusion of silkworm pupae meal (SPM) on nutrient digestibility, nitrogen utilization, gastrointestinal physiology and blood biochemical parameters in rabbits. Thirty Termond White rabbits were divided into three groups: SBM – fed a diet containing 10% soybean meal (SBM), SPM5 – fed a diet containing 5% SBM and 5% SPM, and SPM10 – fed a diet containing 10% SPM. Results Nutrient digestibility and nitrogen retention decreased with increasing SPM inclusion levels in rabbit diets. The dietary inclusion of SPM caused a significant increase in the stomach pH. Group SPM10 rabbits were characterized by the highest cecal tissue and digesta weights. The lowest cecal pH was noted in group SPM5. The relative weights of colonic tissue and digesta tended to increase with increasing levels of SPM. The total and intracellular activity of bacterial α-galactosidase decreased significantly in both SPM groups. The replacement of SBM with SPM led to a decrease in the activity of bacterial β-glucuronidase in the cecal digesta. The intracellular activity of bacterial α-arabinofuranosidase increased, and its release rate decreased in the cecum of rabbits in SPM groups. The extracellular activity of bacterial β-xylosidase in the cecal digesta tended to decrease in group SPM10. The highest extracellular and intracellular activity of bacterial β-cellobiosidase in the cecal digesta was noted in the SPM5 treatment. The lowest and the highest activity of bacterial N-acetyl-β-D-glucosaminidase (NAGase) was observed in groups SBM and SPM10. The SPM10 treatment contributed to a decrease in the cecal concentrations of butyric, iso-valeric and valeric acids. The lowest total concentration of putrefactive short-chain fatty acids (PSCFAs) was observed in group SPM10. The cecal concentration of propionic acid tended to increase in group SPM5, whereas the cecal concentration of iso-butyric acid tended to decrease in group SPM10. The colonic concentration of iso-valeric acid was lowest in group SPM5. SPM treatments resulted in a significant increase in plasma albumin concentration. Plasma urea concentration was significantly higher in group SPM10 than in SBM and SPM5. Conclusions The results of this study suggest that rabbit diets can be supplemented with SPM at up to 5%.

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“…High concentration of Cu may be found in the brain, liver, and kidney [ 1 ]. Cu is involved in the regulation of many biochemical processes, including an iron metabolism and hemoglobin synthesis [ 2 , 3 , 4 , 5 ]; immune response [ 6 , 7 , 8 ]; proper functioning of the nervous system, in which it plays an important role in nerve myelination; synthesis of norepinephrine; and endorphin activity [ 9 , 10 ]. In addition, Cu is a catalytic cofactor of enzymes (Cu-dependent enzymes, also known as ‘cuproenzymes’), which are crucial for the redox balance that have implications in energy metabolism and antioxidant defense [ 11 , 12 , 13 ], for example cytochrome C oxidase; the terminal oxidase in most aerobic organisms that reduces molecular oxygen (O 2 ) to water [ 10 ]; and superoxide dismutase (SOD1 and SOD3) [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Dietary Copper Deficiency Leads to Changes in Gene Expression Indicating an Increased Demand for NADH in the Prefrontal Cortex of the Rat’s Brain

Cendrowska-Pinkosz

Ostrowska-Leśko

Ognik

et al. 2022

IJMS

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Copper is an essential element to brain cells as it is a cofactor and a structural component of various enzymes involved in energy metabolism pathways. Accumulating evidence points to the pivotal role of copper deficiency in neurodegeneration resulting from impaired copper homeostasis. Despite the indisputable role of copper in mitochondrial respiration, its homeostasis regulation in the brain tissue remains unclear. The assessment of changes in the expression of genes encoding key pathways of energy metabolism can greatly benefit further studies exploring copper’s role in neurodegeneration. Using a rat model, we investigate whether the replacement of the inorganic form of copper with metallic nanoparticles containing copper or complete deprivation of copper from the diet have an impact on the expression of genes involved in energy metabolism in the prefrontal cortex of the rats’ brain. Herein, we indicate that removing inorganic copper from the normal standard diet or the replacement with copper nanoparticles can lead to programmed energy metabolism changes. It can be recognized that some of these changes indicate an increased demand for NADH in the prefrontal cortex of the rat’s brain, probably as a result of adaptation effect.

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The effect of copper level in the diet on the distribution, and biological and immunological responses in a rat model

Cited by 5 publications

References 42 publications

Effect of Different Levels and Sources of Dietary Copper, Zinc and Manganese on the Performance and Immune and Redox Status of Turkeys

Effect of Different Levels and Sources of Dietary Copper, Zinc and Manganese on the Performance and Immune and Redox Status of Turkeys

The effect of dietary supplementation with silkworm pupae meal on gastrointestinal function, nitrogen retention and blood biochemical parameters in rabbits

Dietary Copper Deficiency Leads to Changes in Gene Expression Indicating an Increased Demand for NADH in the Prefrontal Cortex of the Rat’s Brain

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