Effect of controlled alterations in maternal dietary retinol on foetal and neonatal retinol status and pregnancy outcome in pigs

Antipatis, Christos; Finch, Angela M.; Ashworth, Cheryl

doi:10.1016/j.livsci.2008.01.026

Cited by 9 publications

(6 citation statements)

References 29 publications

(29 reference statements)

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“…The mechanism underlying this phenotype is hypothesized to involved vitamin A‐dependent alterations to the stimulated hormonal environment of the maturing follicle that favor meiotic resumption of meiosis in oocytes (Whaley et al, ). Conversely, a modest reduction in vitamin A from 100 days before mating until the end of the first month of pregnancy, intended to increase retinol‐binding protein in the uterus and porcine fetal fluids, also reduced the incidence of low birth weight piglets and within‐litter variability in birth weights (Antipatis, Finch, & Ashworth, ). The contribution of vitamin A to in follicle maturation is hypothesized to involve an IGF1‐dependent mechanism that ultimately affects the uniformity of embryonic development (Ashworth et al, ; Giudice, ; Hammond, Mondschein, Samaras, & Canning, ).…”

Section: Physiological Alterations In Porcine Iugr Conceptuses and Comentioning

confidence: 99%

Physiological alterations associated with intrauterine growth restriction in fetal pigs: Causes and insights for nutritional optimization

Wang

Feng

Liu

et al. 2017

Molecular Reproduction Devel

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Intrauterine growth restriction (IUGR) remains a major problem in swine production since the associated low birth weight leads to high rates of pre-weaning morbidity and mortality plus permanent retardation of growth and development. Complex biological events-including genetics, epigenetics, maternal maturity, maternal nutrition, placenta efficiency, uterine capacity, and other environmental factors-can affect fetal growth and development during late gestation, as well as maturity of oocytes, duration of estrus, and both implantation and placentation of conceptuses in uteri of sows. Understanding the physiological changes related to initiation and progress of IUGR are, therefore, of great importance to formulate nutritional strategies that can mitigate IUGR in gilts and sows. Altering the nutritional status of sows prior to mating and during early-, mid-, and late-gestation may be effective at increasing the uniformity of oocytes and conceptuses, decreasing variation among conceptuses during elongation and implantation, and preventing increases in within-litter variation in fetal weights during late gestation. This review summarizes current progress on physiological alterations responsible for IUGR fetuses, as well as possible nutritional interventions to prevent the initiation and continuation of IUGR in gilts and sows.

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Section: Physiological Alterations In Porcine Iugr Conceptuses and Comentioning

confidence: 99%

Physiological alterations associated with intrauterine growth restriction in fetal pigs: Causes and insights for nutritional optimization

Wang

Feng

Liu

et al. 2017

Molecular Reproduction Devel

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“…Selection against peri-natal mortality (up to day 5) yields slightly higher heritabilities (Grandinson et al 2002; Su et al 2008) than later pre-weaning mortality (Su et al 2008). Genetic correlations between peri-natal and later survival are reported to be low indicating that peri-natal and post-natal piglet survival are under different genetic control (Arango et al 2006;Su et al 2008;Roehe et al 2009Roehe et al , 2010, and should be treated as different traits. This supports research examining phenotypic traits of piglet survival under outdoor conditions (Baxter et al 2009, 2011): peri-natal survival was explained by piglet shape and size, whereas post-natal survival relied heavily on piglet and maternal behaviour.…”

Section: Selection For Piglet Survivalmentioning

confidence: 99%

The welfare implications of large litter size in the domestic pig I: biological factors

et al. 2013

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Increasing litter size has long been a goal of pig breeders and producers, and may have implications for pig (Sus scrofa domesticus) welfare. This paper reviews the scientific evidence on biological factors affecting sow and piglet welfare in relation to large litter size. It is concluded that, in a number of ways, large litter size is a risk factor for decreased animal welfare in pig production. Increased litter size is associated with increased piglet mortality, which is likely to be associated with significant negative animal welfare impacts. In surviving piglets, many of the causes of mortality can also occur in non-lethal forms that cause suffering. Intense teat competition may increase the likelihood that some piglets do not gain adequate access to milk, causing starvation in the short term and possibly long-term detriments to health. Also, increased litter size leads to more piglets with low birth weight which is associated with a variety of negative long-term effects. Finally, increased production pressure placed on sows bearing large litters may produce health and welfare concerns for the sow. However, possible biological approaches to mitigating health and welfare issues associated with large litters are being implemented. An important mitigation strategy is genetic selection encompassing traits that promote piglet survival, vitality and growth. Sow nutrition and the minimisation of stress during gestation could also contribute to improving outcomes in terms of piglet welfare. Awareness of the possible negative welfare consequences of large litter size in pigs should lead to further active measures being taken to mitigate the mentioned effects.

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“…Alterations in dietary retinol could improve pregnancy outcome by decreasing both the incidence of low-birth-weight piglets and within-litter variation in birth weight (Whaley et al, 2000;Antipatis et al, 2008). Treatment of sows with vitamin A at weaning increased subsequent litter size through decreased embryonic mortality (Coffey and Britt, 1993) and synchronous development of embryos (Pope et al, 1990).…”

Section: Vitamin A/retinolmentioning

confidence: 99%

“…Providing a vitamin A-deficient diet for 100 d prior to mating and during the first month of pregnancy increased the uniformity of birth weights and showed a tendency to decrease the incidence of lowbirth-weight piglets (Antipatis et al, 2008). Moreover, sows on vitamin A-deficient diets did not experience a reduction in fetal survival and growth at Day 30 of pregnancy , perhaps due to a compensatory increase in the abundance of retinol binding protein (RBP) (Antipatis et al, 2008).…”

Section: Retinol/vitamin Amentioning

confidence: 99%

“…Moreover, sows on vitamin A-deficient diets did not experience a reduction in fetal survival and growth at Day 30 of pregnancy , perhaps due to a compensatory increase in the abundance of retinol binding protein (RBP) (Antipatis et al, 2008). Since pig conceptuses secrete RBP prior to onset of elongation and throughout the peri-implantation period, RBP could be an important component of the uterine secretions for early embryonic development (Harney et al, 1990;Schweigert et al, 1999).…”

Section: Retinol/vitamin Amentioning

confidence: 99%

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Within-litter variation in birth weight: impact of nutritional status in the sow

Yuan

Zhu

Shi

et al. 2015

J. Zhejiang Univ. Sci. B

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Accompanying the beneficial improvement in litter size from genetic selection for high-prolificacy sows, within-litter variation in birth weight has increased with detrimental effects on post-natal growth and survival due to an increase in the proportion of piglets with low birth-weight. Causes of within-litter variation in birth weight include breed characteristics that affect uterine space, ovulation rate, degree of maturation of oocytes, duration of time required for ovulation, interval between ovulation and fertilization, uterine capacity for implantation and placentation, size and efficiency of placental transport of nutrients, communication between conceptus/fetus and maternal systems, as well as nutritional status and environmental influences during gestation. Because these factors contribute to within-litter variation in birth weight, nutritional status of the sow to improve fetal-placental development must focus on the following three important stages in the reproductive cycle: pre-mating or weaning to estrus, early gestation and late gestation. The goal is to increase the homogeneity of development of oocytes and conceptuses, decrease variations in conceptus development during implantation and placentation, and improve birth weights of newborn piglets. Though some progress has been made in nutritional regulation of within-litter variation in the birth weight of piglets, additional studies, with a focus on and insights into molecular mechanisms of reproductive physiology from the aspects of maternal growth and offspring development, as well as their regulation by nutrients provided to the sow, are urgently needed.

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Effect of controlled alterations in maternal dietary retinol on foetal and neonatal retinol status and pregnancy outcome in pigs

Cited by 9 publications

References 29 publications

Physiological alterations associated with intrauterine growth restriction in fetal pigs: Causes and insights for nutritional optimization

Physiological alterations associated with intrauterine growth restriction in fetal pigs: Causes and insights for nutritional optimization

The welfare implications of large litter size in the domestic pig I: biological factors

Within-litter variation in birth weight: impact of nutritional status in the sow

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