The constrained groove pressing-cross route process was implemented on a commercially annealed AA5052 alloy at room temperature, with up to two passes (strain of ∼4.64) along the rolling direction and transverse direction. The results showed the formation of an ultrafine-grained structure with an average sub-grain/cell size in the 300–500 nm range. The indentation hardness and tensile strength increased significantly, up to ∼75 and 105%, respectively, and became more homogenous with a uniform and isotropic trend, as compared to the annealed alloy. According to the Hall–Petch and Taylor models used, grain refinement and increasing dislocation density were proposed as the main strengthening mechanisms. Fractographic studies revealed a ductile-fracture behaviour, with a dimpled structure proportional to the UFG structure.