Effect of conjugated linoleic acid on body fat, tumor necrosis factor alpha and resistin secretion in spontaneously hypertensive rats

Hernández-Diaz, Guillermo; Alexander‐Aguilera, Alfonso; Arzaba-Villalba, Agustín; Soto-Rodríguez, Ida; Garcı́a, Hugo S.

doi:10.1016/j.plefa.2009.12.004

Cited by 15 publications

(11 citation statements)

References 37 publications

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“…Moreover, Hernández‐Díaz et al. () showed that CLA reduces the serum resistin level in spontaneously hypertensive rats. Nevertheless, the significantly increased resistin levels in liver and intraperitoneal fat in this study are inconsistent with those observed in rodents.…”

Section: Discussionmentioning

confidence: 99%

“…It has been shown that adipokines (such as adiponectin, leptin and resistin) play an important role in the physiological homeostasis of lipid/CLA metabolism (AL‐Suhaimi & Shehzad, ; Deepa & Dong, ; Hernández‐Díaz, Alexander‐Aguilera, Arzaba‐Villalba, Soto‐Rodríguez, & García, ; Koerner, Kratzsch, & Kiess, ). However, limited information is available about the effects of dietary CLA on tissue adipocytokine levels in fish species.…”

Section: Introductionmentioning

confidence: 99%

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Effects of dietary conjugated linoleic acid on growth performance, tissue adipocytokine levels and lipid metabolism of grass carp

et al. 2018

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A 65‐day growth trial was conducted to investigate the effects of dietary conjugated linoleic acid (CLA) on growth performance, tissue adipocytokine levels and lipid metabolism of grass carp. Seven isonitrogenous and isolipidic diets were formulated as follows: 0 (control), 5 (CLA5), 10 (CLA10), 15 (CLA15), 20 (CLA20), 25 (CLA25) and 30 (CLA30) g/kg CLA. Results showed that incorporating as low as 25 g/kg CLA in the diet significantly decreased the growth of grass carp. The liver lipid content in fish fed with CLA15 to CLA30 significantly decreased. The leptin and resistin levels in liver of fish fed with CLA5 to CLA30 diets significantly increased. The mRNA expression levels of fatty acid synthase (FAS) and triacylglycerol lipase (TGL) in liver of fish fed with CLA5 to CLA30 and CLA10 to CLA30 diets also significantly decreased, respectively. In summary, the lipid‐lowering effects in grass carp liver were induced by the supplementation of 15–20 g/kg CLA, but its growth remained unaffected. Moreover, the lipid‐lowering effects of CLA on grass carp could also be modulated both by adipocytokine levels and by the expression of genes involved in lipid metabolism in tissues.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of dietary conjugated linoleic acid on growth performance, tissue adipocytokine levels and lipid metabolism of grass carp

et al. 2018

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“…Lactobacillus plantarum is one of the strains of Lactic acid bacteria capable to produce nutritious and valuable products such as Conjugated Linoleic Acid (CLA). CLA is a natural derivative of the essential fatty acid (linoleic acid) and has received increasing attention in recent years due to its health e ects potential [1], such as having anticarcinogenic activity [2][3][4], enhancing the immune system, or decreasing body fat content [5]. CLA is not a single substance but actually a mixed group of positional and geometrical isomers of linoleic The use of biological reactions to produce CLA is recommended.…”

Section: Introductionmentioning

confidence: 99%

Comparison and optimization of conjugated linoleic acid production by Lactobacillus plantarum and Lactobacillus plantarum subsp. plantarum

2017

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Abstract. Conjugated Linoleic Acid (CLA) was produced from castor oil using washed cells of Lactobacillus plantarum PTCC 1058 and Lactobacillus plantarum subsp. plantarum PTCC1745 as the catalyst. Under the optimal reaction conditions, the washed cells of Lactobacillus plantarum PTCC1058 produced 1661.26 mg of CLA/L reaction mixture (36% yield of production) from 4.6 mg/ml of castor oil after using 15% (w/v) cell for 121 h. The resulting CLA was a mixture of two CLA isomers, cis-9, trans-11 (or trans-9, cis-11)-octadecadienoic acid (CLA1, 44% of total CLA) and trans-10, cis-12-octadecadienoic acid (CLA2, 46% of total CLA). The total production of CLA is extracellular in all of the reactions performed with Lactobacillus plantarum PTCC1058. Also, Lactobacillus plantarum PTCC1745 produced 1590.31 mg of CLA/L reaction mixture (16.5% production yield) from 9.6 mg/ml of castor oil after using 15% (w/v) cell for 121 h. Therefore, Lactobacillus plantarum PTCC1058 was suggested for CLA production due to its more production ability and CLA extracellular production.

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“…Different studies have demonstrated that consumption of Omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may reduce the risk of developing cardiovascular diseases [ 29 , 30 ]. The anti-thrombotic, anti-inflammatory and vasoprotector effects of PUFAs on the cardiovascular system have been reported [ 31 , 32 ]. Antioxidant propierties of DHA have been also demonstrated since it decreased ROS formation and bound to free radicals preventing tissue oxidation [ 33 – 35 ].…”

Section: Introductionmentioning

confidence: 99%

Dietary docosahexaenoic acid supplementation prevents the formation of cholesterol oxidation products in arteries from orchidectomized rats

et al. 2017

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Testosterone deficiency has been correlated with increased cardiovascular diseases, which in turn has been associated with increased oxidative stress. Several studies have considered cholesterol oxidation products (COPs) as oxidative stress biomarkers, since some of them play pro-oxidant and pro-inflammatory roles. We have previously described the cardioprotective effects of a dosahexaenoic acid (DHA) supplemented diet on the aortic and mesenteric artery function of orchidectomized rats. The aim of this study was to investigate whether impaired gonadal function alters the formation of COPs, as well as the potential preventive role of a DHA-supplemented diet on that effect. For this purpose, aortic and mesenteric artery segments obtained from control and orchidectomized rats, fed with a standard or supplemented with DHA, were used. The content of the following COPs: 7α-hydroxycholesterol, 7β-hydroxycholesterol, 7-ketocholesterol, 5,6α-epoxycholesterol, 5,6β-epoxycholesterol, cholestanetriol and 25-hydroxycholesterol, were analyzed by gas chromatography. The results showed that orchidectomy increased the formation of COPs in arteries from orchidectomized rats, which may participate in the orchidectomy-induced structural and functional vascular alterations already reported. The fact that the DHA-supplemented diet prevented the orchidectomy-induced COPs increase confirms the cardiovascular protective actions of DHA, which could be of special relevance in mesenteric arterial bed, since it importantly controls the systemic vascular resistance.

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Effect of conjugated linoleic acid on body fat, tumor necrosis factor alpha and resistin secretion in spontaneously hypertensive rats

Cited by 15 publications

References 37 publications

Effects of dietary conjugated linoleic acid on growth performance, tissue adipocytokine levels and lipid metabolism of grass carp

Effects of dietary conjugated linoleic acid on growth performance, tissue adipocytokine levels and lipid metabolism of grass carp

Comparison and optimization of conjugated linoleic acid production by Lactobacillus plantarum and Lactobacillus plantarum subsp. plantarum

Dietary docosahexaenoic acid supplementation prevents the formation of cholesterol oxidation products in arteries from orchidectomized rats

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