Effect of conductive hearing loss on central auditory function

Bayat, Arash; Farhadi, Mohammad; Emamdjomeh, Hesam; Saki, Nader; Mirmomeni, Golshan; Rahim, Fakher

doi:10.1016/j.bjorl.2016.02.010

Cited by 16 publications

(19 citation statements)

References 24 publications

(35 reference statements)

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“…If FMRP‐rich sensory neurons are significant targets in FXS, one might expect to see that these neurons exhibit structural and/or functional plasticity in response to changes in neuronal activity in normal brains and that such activity‐dependent plasticity is compromised when FMRP is absent. Indeed, hearing loss or abnormal hearing induced by tinnitus leads to extensive alternations in cellular properties of auditory neurons throughout the brain (Rubel and Fritzsch, ; Parks and Rubel, ; Saunders, ; Berger and Coomber, ; Tong et al, ; Ryugo, ; Bayat et al, ). In FMR1 knockout mice, auditory brainstem neurons show altered synaptic connectivity and reduced activity‐dependent regulation of ion channel expression and conductance (Brown and Kaczmarek, ; Rotschafer et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Scale bar 5 100 lm. neurons throughout the brain (Rubel and Fritzsch, 2002;Parks and Rubel, 2004;Saunders, 2007;Berger and Coomber, 2015;Tong et al, 2015;Ryugo, 2015;Bayat et al, 2016). In FMR1 knockout mice, auditory brainstem neurons show altered synaptic connectivity and reduced activity-dependent regulation of ion channel expression and conductance (Brown and Kaczmarek, 2011;Rotschafer et al, 2015).…”

Section: Fmrp Distribution In the Mouse Brainmentioning

confidence: 99%

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Cellular distribution of the fragile X mental retardation protein in the mouse brain

Zorio

Jackson

Liu

et al. 2016

J of Comparative Neurology

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The fragile X mental retardation protein (FMRP) plays an important role in normal brain development. Absence of FMRP, caused by transcriptional silencing of FMR1 gene, results in abnormal neuronal morphologies in a selected manner throughout the brain and leads to intellectual deficits and sensory dysfunction in the fragile X syndrome (FXS). Despite the paramount importance of FMRP for proper brain function, its overall expression pattern in the mammalian brain at the resolution of individual neuronal cell groups is not known. In this study, we used FMR1 knockout and their isogenic wild type mice to systematically map the distribution of FMRP expression in the entire mouse brain. Using immunocytochemistry and cellular quantification analyses, we identified a large number of prominent cell groups expressing high levels of FMRP at the subcortical levels, in particular sensory and motor neurons in the brainstem and thalamus. In contrast, many cell groups in the midbrain and hypothalamus exhibit low FMRP levels. More importantly, we describe differential patterns of FMRP distribution in both cortical and subcortical brain regions. Almost all major brain areas contain high and low levels of FMRP cell groups adjacent to each other or between layers of the same cortical areas. These differential patterns indicate that FMRP expression is specific to individual neuronal cell groups, instead of associated with brain regions as previously considered. Taken together, these findings support the notion that FMRP mechanisms of neuronal regulation are cell-type specific and strongly implicate the contribution of fundamental sensory and motor processing at subcortical levels to FXS pathology.

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Section: Discussionmentioning

confidence: 99%

Section: Fmrp Distribution In the Mouse Brainmentioning

confidence: 99%

Cellular distribution of the fragile X mental retardation protein in the mouse brain

Zorio

Jackson

Liu

et al. 2016

J of Comparative Neurology

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“…In schools, the association between learning disabilities and hearing complaints is frequent, particularly in relation to noise, with studies having shown a worse performance of this pediatric population in both behavioral and electrophysiological hearing tests (2,3) . In addition, the peripheral changes and/or a history of serous otitis media, frequent in early childhood, may compromise the maturation of the auditory pathways, with repercussions on the central auditory skills and, consequently, on the process of learning (4,5) .…”

Section: Introductionmentioning

confidence: 99%

Triagem do processamento auditivo central: contribuições do uso combinado de questionário e tarefas auditivas

Souza

Carvalho

Plotegher

et al. 2018

Audiol., Commun. Res.

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RESUMO Objetivo Analisar o desempenho de escolares em uma bateria de triagem do processamento auditivo e comparar com um questionário de autopercepção. Além disso, comparar as respostas das crianças com questionário respondido pelos pais. Métodos Participaram 67 escolares com média de idade de 9,58 anos (±1,06), divididos em Grupo I (GI), composto por 40 crianças com desenvolvimento normal e bom desempenho escolar (23 meninas), e Grupo II (GII), composto por 27 crianças com dificuldades escolares (12 meninas). Foram realizados meatoscopia, imitanciometria, avaliação simplificada do processamento auditivo (ASPA) e questionário baseado no Scale of Auditory Behaviors. Resultados No total, 2 crianças do GI (5%) e 14 do GII (51,9%) tiveram desempenho alterado na ASPA. A tarefa de ordenação temporal para sons verbais demonstrou desempenho estatisticamente inferior do GII, em relação ao GI (p=0,001). No questionário, 14 crianças (35%) do GI e 23 (85,2%) do GII foram identificadas como risco para o TPAC (p<0,001). Houve correlação positiva de grau moderado entre desempenho na ASPA e o questionário (p<0,05). Na comparação das respostas das crianças e dos pais, considerando cada grupo separadamente, não houve diferença para o GI (p=0,894) e GII (p=0,239) e na amostra completa (p=0,363). Conclusão Ambos os instrumentos foram capazes de diferenciar os grupos estudados e identificar escolares que necessitam de encaminhamento para realizar o diagnóstico. A partir da análise de correlação, concluiu-se que a ASPA e o questionário devem ser utilizados de forma complementar, independentemente de serem aplicados com a criança ou os pais.

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“…Conductive hearing loss (CHL) following COM may be attributed to factors such as tympanic membrane perforation, ossicular chain disruption, or middle ear space inflammation. It is well documented that long-term sensory deprivation resulting from CHL will produce irreversible changes in the anatomical and functional integrity of the central auditory system structures [13][14][15][16][17] which may lead to the outbreak of language, cognitive, psychological and emotional problems in person 18,19 . In COM cases, infection through bone erosion can also be spared out in mastoid cortex, petrous part of the temporal bone, facial nerve, lateral sinus and dura matter.…”

Section: Discussionmentioning

confidence: 99%

Ossicular chain defects in adults with chronic otitis media

Bayat¹,

Saki²,

Farshad³

et al. 2019

The International Tinnitus Journal

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Background and objective: Chronic otitis media (COM) is a common condition characterized by the perforation of the tympanic membrane and inflammation of the mucosal lining the hollow space in the middle ear and airy spaces of the temporal bone for at least 2-6 week. This study was carried out to find out the status of the middle ear ossicles in patients with COM and to correlate their status with clinical parameters. Methods: This retrospective clinical study was conducted on 107 COM patients (52 males and 55 females; age range: 18 to 75 years) submitted to surgery in the Otology Clinic at

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Effect of conductive hearing loss on central auditory function

Abstract: The results suggest reduced auditory temporal processing ability in adults with CHL compared to normal hearing subjects. Therefore, developing a clinical protocol to evaluate auditory temporal processing in this population is recommended.

Cited by 16 publications

References 24 publications

Cellular distribution of the fragile X mental retardation protein in the mouse brain

Cellular distribution of the fragile X mental retardation protein in the mouse brain

Triagem do processamento auditivo central: contribuições do uso combinado de questionário e tarefas auditivas

Ossicular chain defects in adults with chronic otitis media

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