Ossicular chain defects in adults with chronic otitis media

Bayat, Arash; Saki, Nader; Farshad, Mohammad Amin; Lotfinia, Mojtaba

doi:10.5935/0946-5448.20190002

Cited by 10 publications

(14 citation statements)

References 16 publications

(23 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the case of chronic otitis media with inflammatory granulation, the healing process does not occur as active inflammation (through pro-inflammatory factors) activates the tissue to inflammatory reaction, the final effect of which can be the observed process of transformation into polyps in the middle ear. An active inflammatory process is evidenced by a large influx of leukocytes: neutrophils and lymphocytes, which are sources of pro-inflammatory cytokines (IL-1 a/b, IL-6, IL-8, TNF) as well as the antagonist group composed of anti-inflammatory cytokines (IL-4, -5, -10, -13) [10,11]. The raised concentration of pro-inflammatory cytokines enhances their direct influence on osteoclasts, increasing differentiation and stimulating their resorption properties.…”

Section: Discussionmentioning

confidence: 99%

Chronic suppurative otitis media with cholesteatoma and chronic otitis media with granulation by scanning electron microscopy based on analysis of 140 patients

et al. 2021

View full text Add to dashboard Cite

Objectives Chronic purulent cholesteatoma of the middle ear, as well as to a lesser extent chronic granulomatous otitis media, lead to destruction of bone structures within the middle ear space. Above process is controlled by the OPG/RANKL/RANK system. Material and methods An analysis of 140 patients operated on due to chronic otitis media was performed. For the detailed analysis in the scanning electron microscope, 40 patients were selected who had been diagnosed with chronic cholesteatoma of the middle ear and chronic granulomatous otitis media. Finally the study in SEM included 20 patients. Results The regular structure of cholesteatoma depicted in the Scanning Electron Microscope concerned 5 patients with diagnosed. In the remaining 7 patients, the system was irregular and even chaotic. Lack of regularity can also be observed in the case of granulation tissue, which in the SEM image presented itself as an irregular tissue mass without detectable regularities. Conclusions 1. Regular pattern of the cholesteatoma matrix cells observed in some patients with chronic cholesteatoma of the middle ear reduces the molecular permeability of inflammatory cytokines, concurrently limiting the destructive activity on bone structures. 2. The presence of inflammatory granulation tissue in the middle ear is accompanied by an influx of leukocytes: neutrophils and lymphocytes, which are the source of pro-inflammatory cytokines, the growth of which activates the processes leading to the damage of bone tissue and the development of inflammation. 3. No specimen of acquired cholesteatoma revealed presence of commensalism like organism on the surface of exfoliated human epithelium of Demodex species.

show abstract

Section: Discussionmentioning

confidence: 99%

Chronic suppurative otitis media with cholesteatoma and chronic otitis media with granulation by scanning electron microscopy based on analysis of 140 patients

et al. 2021

View full text Add to dashboard Cite

show abstract

“…a retraction pocket [10]. Other risk factors include poor condition of the middle ear mucosa, the patient's age, and a lack of hearing improvement after previous operations [6,10,15,16].…”

Section: Discussionmentioning

confidence: 99%

Long-term results of a hearing test in patients operated for chronic otitis media

Boroń

Składzień

2020

Otolaryngol Pol

View full text Add to dashboard Cite

Introduction: Chronic otitis media is characterized by tympanic membrane perforation and conductive hearing loss. In the active form of this disease, there will also be periodic or permanent otorrhea. With a number of surgical techniques available depending on intraoperative findings, otosurgery is the treatment of choice in such cases, the extent of which depends on the type and extent of the pathological changes. Material and Method: We carried out an analysis of 79 patients with chronic otitis media undergoing surgery at the Department of Otolaryngology, Jagiellonian University Medical College in Kraków between 2005 and 2014. Total audiometry was used as a part of hearing assessment, before the surgery, 6 months after the surgery and in the distant 10-year observation period. In addition, each patient completed the questionnaire and was examined by an otolaryngologist. Results: The analysis included 79 patients operated on due to chronic otitis media. The mean bone conduction (for frequencies 500,1000 and 2000 Hz) before surgery was 31.8 dB, it did not differ significantly (p = 0.355) after 6 months after surgery (32.8 dB), while it significantly increased (p < 0.001) in a distant 10-year control of 43.4 dB. The mean air conduction (for frequencies 500, 1000 and 2000 Hz) before the procedure was 57.6 dB, it significantly improved in the early control by 50.5 dB, at p < 0.001. In long-term follow-up it increased again to 61.3 dB and was significantly different from the early postoperative period (p < 0.001). The mean air-bone gap for frequencies 500, 1000 and 2000 Hz before surgery was on average 26.4 dB, it was significantly (p < 0.001) reduced in the postoperative period by 17.6 dB. The level of air-bone gap remained at a similar level in distant control. Conclusions: (1) A completely preserved ossicular chain in the absence of active chronic otitis media is the best prognosis for stable hearing improvement over the years with normal inner ear function; (2) Reoperation worsens the long-term results of a hearing test compared to the first operation.

show abstract

“…Aetiology for the damage of the ossicular chain is mostly due to chronic infection in the ear and traumatic ossicular chain discontinuity. (9,10). Incus is found to be the most vulnerable ossicle and the malleus is the most spared (10,16) The Goal is to improve hearing, prevent further infection, and to achieve a wellaerated middle ear.…”

Section: Introductionmentioning

confidence: 99%

“…(9,10). Incus is found to be the most vulnerable ossicle and the malleus is the most spared (10,16) The Goal is to improve hearing, prevent further infection, and to achieve a wellaerated middle ear. Acute infection of the ear is considered a contraindication as this can result in poor healing, prosthesis extrusion, or both (11).…”

Section: Introductionmentioning

confidence: 99%

Middle ear ossiculoplasty – an experience of a single surgical unit

Jayaweera¹

2020

Ceylon J Otolaryngology

View full text Add to dashboard Cite

Background Middle ear ossiculoplasty refers to the reconstruction of the middle ear ossicular chain when there is an in continuity or fixation of the ossicular chain due to disease process or trauma. Various materials and techniques have been used to regain the function and continuity of the ossicular chain. But the ideal reconstruction materials and techniques are yet to be developed. The first ossiculoplasty was reported in modern medical literature by Matte in 1901. (1) Since then, various people have used different materials and techniques for ossiculoplasty(2). In a Sri Lankan setting, only a few centres of the country perform ossiculoplasty though almost all the Ear nose throat departments in the country perform myringoplasty for CSOM (Chronic suppurative otitis media). The main purpose of myringoplasty is to make the ear safe from recurrent ear infection. Improving hearing is not the main aim for myringoplasty in Sri Lanka though some patients get the hearing benefit. Material and method Gray's total ossicular replacement prosthesis (TORP)and partial ossicular replacement prosthesis (PORP) were used. Retrospective data analysis was carried out from patients who underwent surgery from 1 st of July 2017 for three-year periods and calculated the success rate using the improvement of hearing in postoperative audiograms. Conclusion and recommendations Our experience in ossiculoplasty with TORP and PORP showed a reasonable success rate on hearing for traumatic or infective conductive hearing loss. We recommend carrying out it routinely with myringoplasty in the case of damage ossicular chain in the middle ear. We also recommend the ministry of health to make available other types of ossicular prostheses like angular clip prosthesis and malleus replacement prosthesis in addition to TORP and PORP.

show abstract

Ossicular chain defects in adults with chronic otitis media

Cited by 10 publications

References 16 publications

Chronic suppurative otitis media with cholesteatoma and chronic otitis media with granulation by scanning electron microscopy based on analysis of 140 patients

Chronic suppurative otitis media with cholesteatoma and chronic otitis media with granulation by scanning electron microscopy based on analysis of 140 patients

Long-term results of a hearing test in patients operated for chronic otitis media

Middle ear ossiculoplasty – an experience of a single surgical unit

Contact Info

Product

Resources

About