Effect of conditioning and exercise type on serum creatine kinase and aspartate aminotransferase activity

Siciliano, P.D.; Lawrence, L.M.; Danielsen, Kristin; Powell, D. G.; Thompson, Kent N.

doi:10.1111/j.2042-3306.1995.tb04929.x

Cited by 31 publications

(22 citation statements)

References 17 publications

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“…In this study, elevated plasma AST and CK activities were indicative of muscle cell leakage in both OD80 and OD160. Horses that were conditioned for 8 weeks had attenuated increases in CK and AST activities during a submaximal exercise test (Siciliano et al 1995). The large variability in plasma CK activities between horses during OD160 suggests differences in fitness condition (Figs 6a,b), although fitness was not measured in this study.…”

Section: Discussionmentioning

confidence: 77%

Antioxidant status and muscle cell leakage during endurance exercise

Hargreaves

Kronfeld

Waldron³

et al. 2002

Equine Veterinary Journal

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Antioxidant status of 35 endurance horses was studied during an 80 (OD80) or 160 km (OD160) race. Packed cell volume (PCV), total plasma protein (TPP), plasma ascorbic acid (VIT C), plasma alpha-tocopherol (VIT E) and erythrocyte glutathione (GSH) concentrations, erythrocyte glutathione peroxidase (GPX), plasma aspartate aminotransferase (AST) and plasma creatine kinase (CK) activities were measured at 0, 40, 80 km and 60 min of recovery (REC) at OD80, and 0, 64, 106, 142, 160 km and REC at OD160. In both races, no changes were found in plasma VIT E concentration, but VIT C and GSH concentrations decreased (P<0.05), and mean GPX, AST and CK activities increased from 0 km (P<0.05). Indices of muscle cell leakage (plasma AST and CK) were correlated (r = 0.36 to 0.67; P<0.03) with indices of antioxidant status (VIT C, GSH and GPX). Associations between increased muscle leakage and decreased antioxidant status may, in part, reflect oxidative stress and suggest the testing of antioxidant supplements in endurance horses to improve performance and welfare.

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Section: Discussionmentioning

confidence: 77%

Antioxidant status and muscle cell leakage during endurance exercise

Hargreaves

Kronfeld

Waldron³

et al. 2002

Equine Veterinary Journal

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“…Segundo Siciliano et al (1995) e Câmara e Silva et al (2007), o treinamento pode atenuar o aumento da atividade sérica de AST após exercício físico. Porém, conforme já citado, não foi possível na presente pesquisa confirmar que o treinamento físico reduz a magnitude do aumento de AST sérico após o exercício porque nenhuma avaliação clínica e laboratorial dos mesmos animais foi feita previamente ao treinamento de forma a ser comparada com os resultados obtidos após a prova realizada.…”

Section: Discussionunclassified

Lactacidemia e concentrações séricas de aspartato aminotransferase e creatinoquinase em equinos da raça Quarto de Milha usados em provas de laço em dupla

Caiado

Pissinate²,

Souza

et al. 2011

Pesq. Vet. Bras.

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452Pesq. Vet. Bras. 31(5): 452-458, maio 2011 RESUMO.-O presente estudo teve por objetivo avaliar a influência do exercício físico de alta intensidade e curta duração (provas de laço em dupla) sobre a lactacidemia e as concentrações séricas de aspartato aminotransferase (AST) e creatinoquinase (CK) em equinos durante competição realizada no estado do Espírito Santo. Para tal foram obtidas amostras de soro e plasma de 20 equinos, da raça Quarto de Milha ou mestiços, em três momentos assim definidos: no repouso, uma semana antes da prova atlética, já com o animal em treinamento (T0); antes da prova atléti-ca (T1) e imediatamente após o término da mesma (T2). As referidas amostras foram encaminhadas ao Laboratório Clí-nico do Centro Universitário Vila Velha (UVV) para as análi-ses. Na avaliação da lactacidemia, os resultados registrados nos momentos T0, T1 e T2 foram, respectivamente, de 0,49±0,24mmol/L, 0,93±0,16mmol/L e 9,86±2,09mmol/L. Na avaliação da atividade sérica de AST, os resultados registrados nos momentos T0, T1e T2 foram, respectiva- The aim of the present study was to evaluate the effects of high intensity and short duration physical exercise (roping team competition) on plasma lactate and serum AST and CK concentrations in horses during competition at Espírito Santo state, Brazil. Blood samples were obtained from 20 Quarter Horses, or cross-bred, in three moments: (1) at rest, one week before the competition, with the animals being trained, (2) just before the competition, and (3) immediately after the exercise. The samples were sent to Laboratório Clínico do Centro Universitário Vila Velha for analysis. Plasma lactate concentrations were 0.49±0.24mmol/L, 0.93±0.16mmol/L e 9.86±2.09mmol/L, respectively, on the moments rest and immediately before and after the exercise. Serum concentrations of AST were 189.1±43.6 IU/L, 210.2±46.7 IU/L e 173.1±33.5 IU/L, respectively, on the moments rest and immediately before and after the exercise. Finally, serum concentrations of CK were 110.9±35.2 IU/L, 51.8±15.4 IU/L and 88.2±33.5 IU/L, respectively, on the moments rest and immediately before and after the exercise. Results showed that the imposed physical exercise leaded to a significant elevation of plasma lactate and serum CK without alteration on AST. It was possible to conclude that horses were adapted to the level of exercise performed.

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“…BOFFI et al (2002) found significantly higher blood CK activities in trained horses. Higher levels of CK and AST were found after endurance exercise (HARGREAVES et al, 2002) as well as after short, high intensity exercise (SICILIANO et al, 1995). Likewise, CHIARADIA et al (1998) found no change in CK and LDH activities during training, probably due to myocyte adaptation.…”

Section: Discussionmentioning

confidence: 93%

The effect of training and the Alka competition on oxidative stress and metabolic parameters in two horse breeds

Aladrović¹,

Ljubić²,

Babić³

et al. 2018

Vet. arhiv

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The aim of this study was to investigate the effects of training and the Alka competition upon the activity/ concentrations of antioxidative and muscle enzymes and metabolic parameters, as well as their correlations, in the serum of Thoroughbred (TH) and Croatian Warmblood (CWH) horses. The experiment was carried out on nine THs and seven CWHs. Blood samples were collected 30, 21 and 14 days before the Alka competition, immediately after the competition, and 7 days after. Serum concentrations of malondialdehyde (MDA), the activity of glutathione peroxidase (GSH-Px), total superoxide dismutase (SOD), paraoxonase 1 (PON 1), creatine kinase (CK), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) were determined, as well as glucose, triglyceride, nonesterified fatty acids (NEFA), total cholesterol and high density lipoprotein cholesterol (HDL-C) concentrations. Serum MDA concentrations in both breeds were significantly higher 30 days before the Alka than immediately after the race. Serum activity of SOD in TH was significantly higher 21 days before the Alka compared to the values after 7 days of rest. Serum NEFA concentration in TH was

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Effect of conditioning and exercise type on serum creatine kinase and aspartate aminotransferase activity

Cited by 31 publications

References 17 publications

Antioxidant status and muscle cell leakage during endurance exercise

Antioxidant status and muscle cell leakage during endurance exercise

Lactacidemia e concentrações séricas de aspartato aminotransferase e creatinoquinase em equinos da raça Quarto de Milha usados em provas de laço em dupla

The effect of training and the Alka competition on oxidative stress and metabolic parameters in two horse breeds

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