Effect of compound GB-115 on morphine-induced analgesia

Колик, Л. Г.; Zhukov, V. N.; Seredenin, S. B.

doi:10.1007/s10517-007-0219-3

Cited by 6 publications

(6 citation statements)

References 8 publications

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“…This assumption disagres with our ¿ ndings, because there are strong evidence that afobazole is an agonist of ı 1 -receptors [1,4,6].…”

Section: Resultssupporting

confidence: 88%

“…The mechanism of the anxiolytic effect of the preparation is determined by prevention of stress-induced inhibition of binding in the benzodiazepine site of GABA A receptor [5]. At the same time, the interaction of afobazole with ı 1 -receptors was demonstrated [1,4,6]. Apart from CNS, the ı 1 -receptors were identi¿ ed in other organs and tissues of the organism, including the myocardium [12,13].…”

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confidence: 99%

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On the Mechanism of Antifibrillatory Effect of Afobazole

et al. 2010

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Effect of afobazole on the threshold of electrical fibrillation of the heart was studied on anesthetized rats with intact myocardium. It was shown that the drug considerably increased the threshold of electrical fibrillation of the heart, being not inferior to reference class I antiarrhythmic drugs (lidocaine and procainamide) according to V. Williamse classification. Against the background of preliminary injection of σ-receptor antagonist haloperidol, afobazole exhibited no antifibrillatory activity. These findings and analysis of published reports suggest that antifibrillatory activity of afobazole is determined by its antagonistic influence on σ1-receptors localized in cardiomyocyte cytosol.

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“…This assumption disagres with our ¿ ndings, because there are strong evidence that afobazole is an agonist of ı 1 -receptors [1,4,6].…”

Section: Resultssupporting

confidence: 88%

mentioning

confidence: 99%

On the Mechanism of Antifibrillatory Effect of Afobazole

et al. 2010

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“…Pharmacological study showed that the dipeptide GB-115 is present in blood plasma after peroral administration and injection [3]. Taking into account the results of previous experiments, GB-115 was administered in doses of 0.1-10 mg/kg [6].…”

Section: Methodsmentioning

confidence: 99%

“…A new dipeptide antagonist of cholecystokinin receptors (GB-115) was synthesized from the endogenous anxiogenic tetrapeptide cholecystokinin-4 (V. V. Zakusov Institute of Pharmacology) [4]. Experiments on mice and rats demonstrated antinociceptive and anxiolytic properties of GB-115 [6]. Taking into account the multicomponent effects of regulatory peptides, we can hypothesize that glycine-containing dipeptide GB-115 exhibits immunocorrecting activity.…”

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confidence: 99%

Immunocorrecting properties of GB-115 dipeptide

et al. 2008

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We studied the effects of a new dipeptide with anxiolytic activity (GB-115, N-phenylhexanoyl-glycyl-L-tryptophan amide) on parameters of the immune in intact mice and in animals with secondary immunodeficiency caused by cyclophosphamide. GB-115 in doses of 0.1-10 mg/kg stimulated phagocytic activity of peritoneal macrophages and humoral immune response in intact mice. GB-115 exhibited immunocorrecting activity in animals with secondary immunodeficiency.

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“…Anxiolytic and antinociceptive effects of the compound were demonstrated in in vivo experiments [5,6]. Immunocorrective effects of GB-115 was detected in secondary immunodeficiency induced by cyclophosphamide injection [10].…”

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confidence: 97%

Study of Anti-Inflammatory Effects of GB-115, a Glycine-Containing Retropeptide Cholecystokinin Analog

et al. 2011

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Anti-inflammatory effects of GB-115 compound (N-phenylhexanoyl-glycyl-L-tryptophan amide) injected intraperitoneally in doses of 0.1, 1, and 10 mg/kg were demonstrated on the model of ConA- and carrageenan-induced inflammation. Intraperitoneal injection of GB-115 in a dose of 1 mg/kg to C57Bl/6 female mice with experimental autoimmune encephalomyelitis significantly alleviated the pathological symptoms, improved spontaneous locomotor activity, promoted recovery of thymus weight, and reduced edema and neutrophil infiltration of the perivascular space of the brain tissue. Intraperitoneal injection of GB-115 in a dose of 1 mg/kg suppressed generation of active oxygen forms by neutrophils in the chemiluminescence test.

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Effect of compound GB-115 on morphine-induced analgesia

Cited by 6 publications

References 8 publications

On the Mechanism of Antifibrillatory Effect of Afobazole

On the Mechanism of Antifibrillatory Effect of Afobazole

Immunocorrecting properties of GB-115 dipeptide

Study of Anti-Inflammatory Effects of GB-115, a Glycine-Containing Retropeptide Cholecystokinin Analog

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