Effect of component and surface structure on poly(l-lactide-co-ɛ- caprolactone) (PLCA)-based composite membrane

Liuyun, Jiang; Xu, Lijuan; Ma, Bingli; Ding, Haojie; Tang, Chunyan; Wang, Jinghui; Tang, Shuo; Su, Shengpei

doi:10.1016/j.compositesb.2019.107031

Cited by 13 publications

(12 citation statements)

References 50 publications

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“…. The morphology of the mineral layer is quite similar to apatite coating on various fibrous substrates by SBF immersing method [52,53]. This finding clearly indicates that the porous surface of the electrospun PLLA-HA fibres by acetone treatment significantly enhances the binding ability with Ca and P ions and promotes the heterogeneous apatite mineral growth.…”

Section: Mechanical Propertymentioning

confidence: 53%

Ultrafast bone-like apatite formation on highly porous poly(l-lactic acid)-hydroxyapatite fibres

Zhu

Tang

et al. 2020

Materials Science and Engineering: C

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Mechanical Propertymentioning

confidence: 53%

Ultrafast bone-like apatite formation on highly porous poly(l-lactic acid)-hydroxyapatite fibres

Zhu

Tang

et al. 2020

Materials Science and Engineering: C

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“…The combination of Mg 2+ and Ca 2+ in composite biomaterials has been reported previously in magnesium-substituted hydroxyapatite [37][38][39], Mg bioglass [40] or Mg/HA composites [41]. Some works have demonstrated the potential of Mg 2+ and Ca 2+ in GBR membranes thanks to their bioactivity and biodegradability [42]. Mg/HA composites and their impressive biocompatibility, biodegradability and the possibility to modify the composition ratios has led to further interest in research.…”

Section: Introductionmentioning

confidence: 94%

The Effect of Ca2+ and Mg2+ Ions Loaded at Degradable PLA Membranes on the Proliferation and Osteoinduction of MSCs

et al. 2022

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Biodegradable membranes, including Polylactic acid (PLA)-based membranes, are commonly used in bone-tissue-related clinical procedures as biointerface to promote bone tissue regeneration. Calcium (Ca2+) and Magnesium (Mg2+) ions have been related to the promotion of osteogenesis, where the PLA membranes could be used as carrier and delivery substrate for them to provide osteogenic properties to this material. For this aim, a new ion delivery system based on biodegradable PLA membranes loaded with Mg and hydroxyapatite (HA) particles has been processed by the combination of tape casting and colloidal route. Materials characterization shows that the incorporation of Mg and HA particles changes the surface and hydrophobicity of the PLA membrane, and the in vitro degradation test shows Mg2+ and Ca2+ ion release and occasionally the precipitation of different ion species onto the membrane surface. Mouse and human Mesenchymal Stem Cells (MSC) were used to define the biocompatibility and bioactivity of these PLA membrane composites, and data indicated Mg2+ promotes cell proliferation and potentiates osteoinductive signals, while Ca2+ induces the expression of ALP osteogenic marker in human MSCs. Biodegradable PLA membranes loaded with Mg and HA particles is a promising new ion delivery system of Mg2+ and Ca2+ ions that provides osteogenic signals and works as functional biointerface interfaces with bone tissues.

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“…Most of these polymers degrade into components that are metabolized in the body. Moreover, the mechanical properties and degradation time can be controlled by combining these polymers (as copolymers or blends) [ 20 , 59 , 64 , 74 , 76 , 86 , 102 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 ].…”

Section: Scaffold For Articular Cartilage Repair: Requirements Mamentioning

confidence: 99%

Review of Synthetic and Hybrid Scaffolds in Cartilage Tissue Engineering

2020

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Cartilage tissue is under extensive investigation in tissue engineering and regenerative medicine studies because of its limited regenerative potential. Currently, many scaffolds are undergoing scientific and clinical research. A key for appropriate scaffolding is the assurance of a temporary cellular environment that allows the cells to function as in native tissue. These scaffolds should meet the relevant requirements, including appropriate architecture and physicochemical and biological properties. This is necessary for proper cell growth, which is associated with the adequate regeneration of cartilage. This paper presents a review of the development of scaffolds from synthetic polymers and hybrid materials employed for the engineering of cartilage tissue and regenerative medicine. Initially, general information on articular cartilage and an overview of the clinical strategies for the treatment of cartilage defects are presented. Then, the requirements for scaffolds in regenerative medicine, materials intended for membranes, and methods for obtaining them are briefly described. We also describe the hybrid materials that combine the advantages of both synthetic and natural polymers, which provide better properties for the scaffold. The last part of the article is focused on scaffolds in cartilage tissue engineering that have been confirmed by undergoing preclinical and clinical tests.

show abstract

Effect of component and surface structure on poly(l-lactide-co-ɛ- caprolactone) (PLCA)-based composite membrane

Cited by 13 publications

References 50 publications

Ultrafast bone-like apatite formation on highly porous poly(l-lactic acid)-hydroxyapatite fibres

Ultrafast bone-like apatite formation on highly porous poly(l-lactic acid)-hydroxyapatite fibres

The Effect of Ca2+ and Mg2+ Ions Loaded at Degradable PLA Membranes on the Proliferation and Osteoinduction of MSCs

Review of Synthetic and Hybrid Scaffolds in Cartilage Tissue Engineering

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