Effect of common bile-duct transplantation on gastric acid secretion in the dog

Breen, J. J.; Molina, E; Ritchie, Wallace P.

doi:10.1002/bjs.1800550411

Cited by 19 publications

(6 citation statements)

References 11 publications

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“…Experimentally, cholecystojejunostomy has been found to be associated with gastric ulceration due to impairment of inhibitory control over gastric acid production by the duodenum. 17,19 Duodenal ulceration can occur because bile, which is mildly alkaline, is not present to neutralise gastric acid as it enters the duodenum. 10 Despite experimental evidence there are no case reports in the literature that confirm this sequela in dogs.…”

Section: Discussionmentioning

confidence: 99%

Pancreatic pseudocyst causing extrahepatic biliary obstruction in a dog

Wyatt

2000

Aust Veterinary J

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A 3-year-old Rhodesian Ridgeback was examined because of recurrent pancreatitis of 2 months duration. The dog had signs of abdominal pain and jaundice. Blood biochemical findings were consistent with extrahepatic bile duct obstruction, but on abdominal ultrasonography no cause of obstruction was identified. At surgery a pancreatic pseudocyst was found in the body of the pancreas. Cystoduodenostomy, cystic omentalization and biliary diversion resulted in excellent long-term recovery.

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Section: Discussionmentioning

confidence: 99%

Pancreatic pseudocyst causing extrahepatic biliary obstruction in a dog

Wyatt

2000

Aust Veterinary J

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“…Based on this finding, Menguy (1961) insisted that hypersecretion of gastric acid after cholecystoileostomy (Roux-en-Y) should be attributed to some factors other than loss of intestinal inhibition related to indigestion of fat due to the interrupted bile flow into the duodenum. Breen et al (1968) performed choledochojejunostomy (Roux-en-Y) in 12 dogs with Heidenhain pouch, and found an increase in gastric acid secretion. Furthermore, hypersecretion of gastric acid was significant early on the 5th day of operation in 4 to 5 dogs with cholecystojejunostomy (Roux-en-Y), contrasted with no increase of the secretion in dogs with cholecystoduodenostomy.…”

Section: Discussionmentioning

confidence: 99%

Influence of biliary diversion upon gastric acid secretion.

Sekine¹,

Tsukui²,

Kameyama³

et al. 1981

Tohoku J. Exp. Med.

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The influence of biliary diversion upon gastric acid secretion and the serum gastrin level was investigated in dogs with Heidenhain pouch. Biliary diversion was carried out by the following operative procedures: 1) External biliary fistula (3 dogs), ligation and division of the common bile duct and construction of an external biliary fistula by inserting a cannula into the gallbladder. 2) Roux-en-Y internal biliary fistula (6 dogs), ligation and division of the common bile duct and construction of an internal fistula (cholecystojejunostomy) by anastomosing the gallbladder to the jejunum 10 cm distal to the ligament of Treitz, with restoration of end-to-side jejunojejunostomy. In each dog, a test meal (Dog Food, 300 g) was administered, and the gastric acid secretion and serum gastrin level were examined. In the external biliary fistula, the gastric acid secretion showed no increase after the test meal, while in the Roux-en-Y internal fistula the secretion from the Heidenhain pouch showed a significant increase in 4 of 6 dogs, with an increase rate of 110-330%. In either the external biliary fistula or the Roux-en-Y internal fistula, the serum gastrin level showed no significant change. However, in the dogs with the Roux-en-Y internal fistula allotted for the observation periods of 4 to 5 months, the serum gastrin level at 3 hr after the test meal was significantly higher than that at fasting. Further, in pursuit of the reproducibility of gastric acid secretion with the Roux-en-Y internal biliary fistula in the course between the first and second Roux-en-Y internal fistulae, the gastric acid secretion markedly increased in the cases of the Roux-en-Y internal fistula, without definite changes in the level of serum gastrin. Acute gastric ulcer developed in 2 of 6 dogs with the Roux-en-Y internal biliary fistula, but no fat indigestion was caused. These results suggest that gastric hypersecretion induced by biliary diversion may prove the possibility of presence of gastric secretagogue, different from gastrin, released in the upper jejunum. biliary diversion; internal biliary fistula; gastric acid secretion; serum gastrin level Biliary-intestinal anastomoses are used for reconstruction of the biliary tract. It has been pointed out that the surgical procedure for reconstruction of the biliary tract, particularly choledochoj ej unostomy, is likely to give rise to peptic ulcer. Recently, McArthur and Longmire (1971) reported an increased incidence of peptic ulcer in a relatively large series of patients who had undergone choledochojejunostomy for benign biliary obstruction. However, the possible

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“…Moreover, recent experimental evidence indicates that the biliary secretion of bicarbonate makes only a negligible contribution to duodenal buffering of acid [K o n t u re k , 1971]. It does not, for instance, explain the gastric hypersecretion observed in experimental animals after biliary diversion [Breen et al, 1968], although other studies suggest that this concept is at least debatable since in certain animal species diversion of bile did not evoke a change in basal acid output [K o On several occasions hepatic damage has been pointed out to be an important etiological factor. It also has been shown that gastric hypersecre tion, resulting from biliary tract obstruction, persists after decompressing the bile ducts, if irreversible liver damage has occurred [Silen et al, 1963], Repeatedly, the diminished ability of the liver to destroy histamine, absorbed from the intestine, has been blamed for this phenomenon [Anrep and Barsoum , 1953].…”

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confidence: 98%

Duodenal Ulceration after Diversion of Bile

Vos¹

1972

Digestion

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Effect of common bile-duct transplantation on gastric acid secretion in the dog

Cited by 19 publications

References 11 publications

Pancreatic pseudocyst causing extrahepatic biliary obstruction in a dog

Pancreatic pseudocyst causing extrahepatic biliary obstruction in a dog

Influence of biliary diversion upon gastric acid secretion.

Duodenal Ulceration after Diversion of Bile

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