Effect of colostrum treated by heat on immunological parameters in newborn lambs

Loste, A.; Ramos, Juan José; Fernández, Antonio; Ferrer, Luís Miguel; Lacasta, Delia; Verde, Maite; Marca, M.C.; Ortı́n, A.

doi:10.1016/j.livsci.2007.12.012

Cited by 30 publications

(29 citation statements)

References 37 publications

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“…The colostral IgG concentrations of control and vitamin Dsupplemented ewes at lambing were within the range of 64.2-99.4 mg/mL reported by previous studies (Gilbert et al 1988;al-Sabbagh et al 1995;Loste et al 2008;Swanson et al 2008). The plasma concentrations of IgG in control and vitamin D-supplemented lambs at 1 and 4 weeks of age were slightly lower than those reported in other breeds of sheep (Yılmaz et al 2011;Gokce et al 2014).…”

Section: Discussionsupporting

confidence: 69%

Supplementation of Merino ewes with cholecalciferol in late pregnancy improves the vitamin D status of ewes and lambs at birth but is not correlated with an improvement in immune function in lambs

et al. 2016

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Functional deficiencies of the immune system are known to predispose human and animal neonates to death. Thus, immune competency may be a significant factor influencing the mortality of lambs.Vitamin D has been recognised to improve immune function and is transferred across the placenta.This study tested the hypotheses that (1) supplementation of Merino ewes with cholecalciferol during late pregnancy will increase the concentrations of vitamin D in the ewe and lamb at birth and (2) supplementation of Merino ewes with cholecalciferol during late pregnancy is correlated with an increase in innate phagocytic and adaptive antibody immune responses in the lamb. Merino ewes Supplementation with cholecalciferol had no significant effect on the phagocytic capacity of monocytes or polymorphonuclear leukocytes, the concentration of IgG in the colostrum or plasma of lambs, or the vaccine-specific antibody response against tetanus toxoid. Overall, the results support our first hypothesis, but suggest that maternal supplementation with 1 × 10 6 IU cholecalciferol does not improve innate, passive or adaptive immune function in lambs.

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Section: Discussionsupporting

confidence: 69%

Supplementation of Merino ewes with cholecalciferol in late pregnancy improves the vitamin D status of ewes and lambs at birth but is not correlated with an improvement in immune function in lambs

et al. 2016

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“…The results were similar to those found in a previous study (Fernández et al 2006, Loste et al 2008. The ingestion of high quality colostrum during the first hours of life is essential for the synthesis and maintenance of the level of serum proteins (Besser & Gay 1994, Constant et al 1994, Weaver et al 2000.…”

Section: Discussionsupporting

confidence: 87%

“…These substitutes are lyophilized bovine colostrum or bovine serum-based colostrum which are commercial available to use directly to animals. Also, pasteurization of colostrum have been used as strategy to control transmition Maedi--Visna virus to newborn (Fernández et al 2006, Loste et al 2008, or destruction of Mycobacterium paratuberculosis experimental inoculated in the cow's colostrum (Stabel et al 2004). The disadvantage of this method is that heat treatment of the colostrum resulted in a reduction in colostral IgG between 25-30% (Stabel et al 2004, Fernández et al 2006), but without affect animal's health.…”

Section: Introductionmentioning

confidence: 99%

Effect of oral administration of Propionibacterium acnes on growth performance, DTH response and anti-OVA titers in goat kids

et al. 2013

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“…The IgG concentration in BC and OC were also measured by RID, described by Mancini et al (1965), and modified by Besser et al (1985). The average IgG concentration determined in the bovine and ovine first milking colostrum were 115.68 6 20.49 mg/ml and 48.13 6 4.98 mg/ml, respectively, similar levels of concentration were found by Pauletti et al (2005) and Loste et al (2008), respectively. These concentrations obtained in the pools represent the average of IgG obtained in a normal commercial operation.…”

Section: Methodsmentioning

confidence: 55%

IgG absorption by Santa Ines lambs fed Holstein bovine colostrum or Santa Ines ovine colostrum

Moretti

Kindlein

Pauletti

et al. 2010

Animal

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The objective of this study was to evaluate the immunoglobulin G (IgG) absorption by Santa Ines lambs under two colostrum management systems usually used by producers. Twenty-seven Santa Ines newborn lambs received two meals of 250 ml of bovine colostrum from Holstein cows (BC group) or ovine colostrum from Santa Ines ewes (OC group) at 0 and 6 h of life. Pools of BC and OC were analyzed by radial immunodiffusion to quantify IgG. Results are expressed as least-square means and standard errors of mean (means 6 s.e.m.). The concentration of IgG in bovine and ovine pools averaged 115.7 6 20.5 and 48.1 6 5.0 mg/ml, respectively, levels of concentration found in similar regular colostrum managements. The efficiency of IgG absorption was evaluated under two aspects, maximum apparent efficiency of absorption and total apparent efficiency of absorption (AEAmax and AEAtotal, respectively). The AEAmax was calculated taking into account the mass of IgG ingested just in the first meal of colostrum at birth and the serum IgG concentration at 6 h while the AEAtotal took into account the serum IgG concentration at 24 h of life that reflects the first colostrum offered at birth and the second meal at 6 h. The IgG and apparent efficiency of absorption results were transformed into the square root and log base 10, respectively, and were presented as geometric leastsquare means. In BC, lower ( P , 0.05) AEAmax and AEAtotal were verified (14.2% and 15.6%, respectively), in relation to OC (23.6% and 24.4%, respectively). Serum IgG concentrations at 24 h were significantly higher ( P , 0.05) in BC (31.4 mg/ml, respectively) compared with OC (22.2 mg/ml, respectively). The results in this study confirm that there is a limitation to the process of IgG absorption by the enterocytes of newborn lambs, which determined a nonlinear behavior of passive immunity acquisition. Similar values of AEAmax and AEAtotal for the two sources of colostrum reveal that the process of IgG absorption from the first and second meals during the first 6 h of life did not change and indicates that the ingestion of a second feeding of quality colostrum can enhance the acquisition of immune protection of newborn lambs.

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Effect of colostrum treated by heat on immunological parameters in newborn lambs

Cited by 30 publications

References 37 publications

Supplementation of Merino ewes with cholecalciferol in late pregnancy improves the vitamin D status of ewes and lambs at birth but is not correlated with an improvement in immune function in lambs

Supplementation of Merino ewes with cholecalciferol in late pregnancy improves the vitamin D status of ewes and lambs at birth but is not correlated with an improvement in immune function in lambs

Effect of oral administration of Propionibacterium acnes on growth performance, DTH response and anti-OVA titers in goat kids

IgG absorption by Santa Ines lambs fed Holstein bovine colostrum or Santa Ines ovine colostrum

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