Effect of Cold Shock on Age-Related Changes in the Glucose Uptake of Brain Slices of Male Garden Lizard

Dash, B.D.; Patnaik, B.K.

doi:10.1159/000213005

Cited by 4 publications

(2 citation statements)

References 14 publications

(20 reference statements)

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“…Cold stress induced a rise (14%) in hepatic LDH activity in young, but caused a decline (18%) in old lizards [77], Cold shock treatment (immersion of hind limbs and tail up to their origin in ice-cold water at 0-4 °C for 5 min) resulted in a rise in mitochondrial SDH activity of the brain of old lizards only. Similarly, the degree of de cline in glucose and glycogen contents of the brain of middle-aged and old were higher than that of young lizards [55], Both mitochondrial protein content and the lactate/pyruvate ratio increased only in the brain of old coldshocked lizards [56], The uptake of glucose decreased in brain slices of cold-shocked liz ards of the old age group with no appreciable effect in similarly treated young and middleaged counterparts [127], In general, it may be observed that the adaptive response to hypothermic stress is less efficient in old than in young and middleaged lizards. Whether a similar effect of age on physiological adaptation to cold is also prevalent in other reptile species needs fur ther investigation.…”

Section: Responses To Cold Stress/cold Shockmentioning

confidence: 90%

Ageing in Reptiles

Patnaik¹

1994

Gerontology

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Like in fishes, the reptiles appear to show three types of senescence. The African skink, Mabuya buettneri, shows rapid senescence similar to death at mating observed in Salmon and marsupial mouse. Most of the lizards and snakes undergo gradual senescence comparable to the pattern exhibited by a majority of vertebrates. On the other hand, turtles, tortoises and crocodiles continue to grow throughout life and are thus credited with slow or negligible senescence. Evidences and mechanisms of rapid or negligible senescence in reptiles are still fragmentary and unclear. Findings in a few species of lizards (Calotes versicolor) and snakes (Natrix natrix) showing gradual senescence support the concept of commonalities in ageing phenomena in vertebrates. An age-related increase in the stability of collagen and accumulation of altered enzyme molecules, a decrease in metabolism and response to stress-enhanced anti-oxidative defence mechanisms and the nature of responses to hormones, restricted diet and lower environmental temperature corroborate the concept. On the other hand neither the increase in mortality rate and accumulation of lipofuscin nor the reproductive senility have been shown conclusively in ageing reptile populations. It is likely that there are multiple mechanisms of senescence in reptiles. Further studies on selected species from among the 6,000 living species are necessary to unravel the phenomena.

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Section: Responses To Cold Stress/cold Shockmentioning

confidence: 90%

Ageing in Reptiles

Patnaik¹

1994

Gerontology

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“…Similar observations were reported in intestinal uptake of D-glucose [Vinardell and Bolufer, 1984;Lindi et al, 1985], The de crease in intestinal glucose uptake during ageing has been implicated with a decrease in the number and/or activity of NaMinked glucose carriers [Doubek and Armbrecht, 1987], A decline in deoxyglucose uptake was observed in ageing rat brain [Le PoncinLafitte and Rapin, 1980], On the other hand, Wheeler [1981] found no significant age change in deoxyglucose uptake in cortical synaptosomes of Long-Evans rat. Dash and Patnaik [1989] found a decline in glucose uptake of brain slices of lizards between young and middle-aged groups followed by an increase in old. It appears that since the glucose requirement of tissues varies, a gen eral pattern of age change in uptake of the metabolite cannot be expected.…”

Section: Resultsmentioning

confidence: 91%