Age-Related Responses of Hepatic Glucose Uptake to Starvation and Cold Stress in Male Garden Lizards

Jena, B.S.; Patnaik, B.K.

doi:10.1159/000213210

Cited by 6 publications

(5 citation statements)

References 20 publications

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“…The degree of decline in glucose uptake of liver slices in response to cold stress was high er in young and middle-aged than in old liz ards [70]. Cold stress induced a rise (14%) in hepatic LDH activity in young, but caused a decline (18%) in old lizards [77], Cold shock treatment (immersion of hind limbs and tail up to their origin in ice-cold water at 0-4 °C for 5 min) resulted in a rise in mitochondrial SDH activity of the brain of old lizards only.…”

Section: Responses To Cold Stress/cold Shockmentioning

confidence: 85%

“…The glucose uptake of liv er and cerebral hemisphere slices did not change during maturation (young to middleaged) but declined during ageing (middleaged to old lizards [70,71]; table 8). The decreased uptake in old lizards suggests meta bolic derangement in the transport of the me tabolite and/or its reduced level of utilisation.…”

Section: Metabolismmentioning

confidence: 94%

“…The decline in glucose uptake of liver slices following 72 h of starvation was age dependent, the young and middle-aged being more responsive than the old lizards [70]. On the other hand, while the glucose uptake of cerebral hemisphere slices did not change in young lizards starved for 72 h, the same parameter increased in similarly treated middle-aged and old lizards [71], The re duced uptake of glucose in the liver of starved lizards of the old age group may be an adaptation to channelise the metabolite to the brain which is critically dependent on glucose [72].…”

Section: Responses To Starvation Stressmentioning

confidence: 94%

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Ageing in Reptiles

Patnaik¹

1994

Gerontology

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Like in fishes, the reptiles appear to show three types of senescence. The African skink, Mabuya buettneri, shows rapid senescence similar to death at mating observed in Salmon and marsupial mouse. Most of the lizards and snakes undergo gradual senescence comparable to the pattern exhibited by a majority of vertebrates. On the other hand, turtles, tortoises and crocodiles continue to grow throughout life and are thus credited with slow or negligible senescence. Evidences and mechanisms of rapid or negligible senescence in reptiles are still fragmentary and unclear. Findings in a few species of lizards (Calotes versicolor) and snakes (Natrix natrix) showing gradual senescence support the concept of commonalities in ageing phenomena in vertebrates. An age-related increase in the stability of collagen and accumulation of altered enzyme molecules, a decrease in metabolism and response to stress-enhanced anti-oxidative defence mechanisms and the nature of responses to hormones, restricted diet and lower environmental temperature corroborate the concept. On the other hand neither the increase in mortality rate and accumulation of lipofuscin nor the reproductive senility have been shown conclusively in ageing reptile populations. It is likely that there are multiple mechanisms of senescence in reptiles. Further studies on selected species from among the 6,000 living species are necessary to unravel the phenomena.

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Section: Responses To Cold Stress/cold Shockmentioning

confidence: 85%

Section: Metabolismmentioning

confidence: 94%

Section: Responses To Starvation Stressmentioning

confidence: 94%

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Ageing in Reptiles

Patnaik¹

1994

Gerontology

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“…Male garden lizards of three different age groups (young, middle-aged and old), collected from Berhampur localities during January to March, were main tained in the laboratory as described earlier [6,7], The young lizards were aged less than 1 year and the middle aged and old 1 and 2-4 years, respectively.…”

Section: Animalsmentioning

confidence: 99%

“…Calotes versico lor which has been successfully used as a suit able model in our previous studies [6,7].…”

mentioning

confidence: 99%

Changes in Catalase Activity and Its Thermolability in Liver and Kidneys of Ageing Male Garden Lizard

Jena¹,

Patnaik²

1992

Gerontology

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Catalase activity in liver and kidneys of male garden lizards remained unchanged during maturation, but showed an increase during ageing. Instead of inactivating catalase, thermal treatment at 60 ± 1 ° C caused a marginal increase in enzyme activity in the liver of middle-aged and kidneys of young lizards with no significant effect in old counterparts. Increase in basal enzyme activity during ageing and the maintenance of resistance against thermal inactivation of the enzyme throughout the life-span support the contention that catalase molecules in lizard tissues are not altered as a function of age, a deviation from the predictions of Orgel’s error catastrophe hypothesis.

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