Effect of coenzyme Q10 plus nicotinamide adenine dinucleotide supplementation on maximum heart rate after exercise testing in chronic fatigue syndrome – A randomized, controlled, double-blind trial

Castro-Marrero, Jesús; Sáez-Francàs, Naia; Segundo, María José; Calvo, Natàlia; Faro, Mònica; Aliste, Luisa; Sevilla, Tomàs Fernández de; Alegre, José

doi:10.1016/j.clnu.2015.07.010

Cited by 55 publications

(49 citation statements)

References 28 publications

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“…The benefits of their administration have been extensively evaluated in several conditions (Braun et al, ; Porter et al, ; Malm et al, ; Cooke et al, ). However, several studies have shown that there is a mitochondrial dysfunction, which reduces the ATP production, as an immediate effect primary or secondary to symptoms in most CFS/ME patients (Twisk and Maes, ; Booth et al, ; Castro‐Marrero et al, ; Myhill et al, ; Castro‐Marrero et al, ).…”

Section: Complementary and Alternative Medicinementioning

confidence: 99%

“…Because CoQ 10 and NADH increase cellular ATP production via mitochondrial oxidative phosphorylation, their supplementation could help improve fatigue and other symptoms in CFS/ME (Nicolson, ; Castro‐Marrero et al, ). For its part, CoQ 10 supplementation alone has been evaluated in many illnesses (such as fibromyalgia) with conflicting findings, but not yet in CFS/ME (Garrido‐Maraver et al, ).…”

Section: Complementary and Alternative Medicinementioning

confidence: 99%

“…Recently our working group (Castro‐Marrero et al, ) conducted a proof‐of‐concept, 8 week RCT in 80 Spanish CFS/ME patients who met the 1994 CDC/Fukuda definition and were allocated to receive CoQ10 plus NADH or matching placebo. Our findings suggested that the combination of CoQ10 plus NADH was safe and potentially effective in reducing the max HR ( P = 0.022) during the exercise challenge test.…”

Section: Complementary and Alternative Medicinementioning

confidence: 99%

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Treatment and management of chronic fatigue syndrome/myalgic encephalomyelitis: all roads lead to Rome

Castro-Marrero

Sáez-Francàs

Santillo

et al. 2017

British J Pharmacology

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This review explores the current evidence on benefits and harms of therapeutic interventions in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) and makes recommendations. CFS/ME is a complex, multi‐system, chronic medical condition whose pathophysiology remains unknown. No established diagnostic tests exist nor are any FDA‐approved drugs available for treatment. Because of the range of symptoms of CFS/ME, treatment approaches vary widely. Studies undertaken have heterogeneous designs and are limited by sample size, length of follow‐up, applicability and methodological quality. The use of rintatolimod and rituximab as well as counselling, behavioural and rehabilitation therapy programs may be of benefit for CFS/ME, but the evidence of their effectiveness is still limited. Similarly, adaptive pacing appears to offer some benefits, but the results are debatable: so is the use of nutritional supplements, which may be of value to CFS/ME patients with biochemically proven deficiencies. To summarize, the recommended treatment strategies should include proper administration of nutritional supplements in CFS/ME patients with demonstrated deficiencies and personalized pacing programs to relieve symptoms and improve performance of daily activities, but a larger randomized controlled trial (RCT) evaluation is required to confirm these preliminary observations. At present, no firm conclusions can be drawn because the few RCTs undertaken to date have been small‐scale, with a high risk of bias, and have used different case definitions. Further, RCTs are now urgently needed with rigorous experimental designs and appropriate data analysis, focusing particularly on the comparison of outcomes measures according to clinical presentation, patient characteristics, case criteria and degree of disability (i.e. severely ill ME cases or bedridden).

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Section: Complementary and Alternative Medicinementioning

confidence: 99%

Section: Complementary and Alternative Medicinementioning

confidence: 99%

Section: Complementary and Alternative Medicinementioning

confidence: 99%

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Treatment and management of chronic fatigue syndrome/myalgic encephalomyelitis: all roads lead to Rome

Castro-Marrero

Sáez-Francàs

Santillo

et al. 2017

British J Pharmacology

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“…Several studies have discovered the pharmacological activities of AG, and these findings demonstrated that AG might have potential for the alleviation of several diseases caused by the oxidative stress, and the main mechanisms include the activation of nuclear factor erythroid-2-related factor 2 and inhibition of nuclear factor-κB activation [2][3][4]. Recent studies have demonstrated that antioxidant supplementation may serve as a practical strategy for the alleviation of physical fatigue through modulating oxidative stress and inflammation status [5][6][7]. For example, the well-known anti-inflammatory curcumin and curcuminoids, which are hydroxycinnamic acid derivatives with polyphenolic rings, have demonstrated the ability to boost exhaustive swimming time and bust exercise fatigue-associated markers, including lactate, ammonia, and blood urea nitrogen (BUN) in mice [8].…”

Section: Introductionmentioning

confidence: 99%

Oral Bioavailability Enhancement and Anti-Fatigue Assessment of the Andrographolide Loaded Solid Dispersion

Yen

Liang

Cheng

et al. 2020

IJMS

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Andrographolide (AG), a major diterpene lactone isolated from Andrographis paniculata (Burm. f.) Nees (Acanthaceae), possesses a wide spectrum of biological activities. However, its poor water solubility and low bioavailability limit its clinical application. Therefore, this study aimed to develop a solid dispersion (SD) formulation to increase the aqueous solubility and dissolution rate of AG. Different drug-polymer ratios were used to prepare various SDs. The optimized formulation was characterized for differential scanning calorimetry, Fourier transform infrared spectroscopy, and powder X-ray diffraction. The analysis indicated that the optimized SD enhanced AG solubility and dissolution rates by changing AG crystallinity to an amorphous state. The dissolution behaviors of the optimum SD composed of an AG-polyvinylpyrrolidone K30-Kolliphor EL ratio of 1:7:1 (w/w/w) resulted in the highest accumulated dissolution (approximately 80%). Pharmacokinetic studies revealed that Cmax/dose and the AUC/dose increased by 3.7-fold and 3.0-fold, respectively, compared with AG suspension. Furthermore, pretreatment using the optimized AG-SD significantly increased the swimming time to exhaustion by 1.7-fold and decreased the plasma ammonia level by 71.5%, compared with the vehicle group. In conclusion, the optimized AG-SD formulation appeared to effectively improve its dissolution rate and oral bioavailability. Moreover, the optimized AG-SD provides a promising treatment against physical fatigue.

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“…It can also increase the vitality of patients undergoing medical treatment and of the elderly residents of nursing homes [16][17][18]. Furthermore, it alleviates fatigue in patients with chronic fatigue syndrome [19,20], hyperlipidemia [21], and in those with end-stage heart failure awaiting cardiac transplantation [22]. In older rats, CoQ 10 supplementation has been shown to alleviate diabetes-induced learning and memory deficits and to improve cognitive performance when administered at a high dose [23].…”

Section: Introductionmentioning

confidence: 99%

Miso Soup Consumption Enhances the Bioavailability of the Reduced Form of Supplemental Coenzyme Q₁₀

Τakahashι

Nagata

Kaneko

et al. 2020

Journal of Nutrition and Metabolism

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Coenzyme Q10 (CoQ10) is an essential compound that is involved in energy production and is a lipid-soluble antioxidant. Although it has been proposed as an antiaging and a health-supporting supplement, its low bioavailability remains a significant issue. Concurrent food intake enhances the absorption of orally administered CoQ10, but it has not been fully established whether specific food substances affect intestinal CoQ10 absorption. Therefore, to determine whether the bioavailability of supplemental CoQ10 is affected by diet, P30, a granulated and reduced form of CoQ10, was dispersed in four different foods, clear soup, miso soup, milk soup, and raw egg sauce. Those foods which contained CoQ10 were consumed on different occasions at intervals of 6–14 weeks by the same participants. Thirteen participants were recruited in the single-dose and repeated clinical study. When miso soup containing P30 was provided, the serum CoQ10 concentration increased faster than when participants consumed other P30-containing soups or a P30-containing raw egg sauce. The area under the curve for serum CoQ10 during the first 5 h after consumption of the P30-containing miso soup was approximately 1.5 times larger than those after the consumption of other P30-containing meals. These data imply that the absorption of CoQ10 supplements can be enhanced by consuming them with food and in particular with specific food substances, such as miso soup.

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Effect of coenzyme Q10 plus nicotinamide adenine dinucleotide supplementation on maximum heart rate after exercise testing in chronic fatigue syndrome – A randomized, controlled, double-blind trial

Cited by 55 publications

References 28 publications

Treatment and management of chronic fatigue syndrome/myalgic encephalomyelitis: all roads lead to Rome

Treatment and management of chronic fatigue syndrome/myalgic encephalomyelitis: all roads lead to Rome

Oral Bioavailability Enhancement and Anti-Fatigue Assessment of the Andrographolide Loaded Solid Dispersion

Miso Soup Consumption Enhances the Bioavailability of the Reduced Form of Supplemental Coenzyme Q₁₀

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Effect of coenzyme Q10 plus nicotinamide adenine dinucleotide supplementation on maximum heart rate after exercise testing in chronic fatigue syndrome – A randomized, controlled, double-blind trial

Cited by 55 publications

References 28 publications

Treatment and management of chronic fatigue syndrome/myalgic encephalomyelitis: all roads lead to Rome

Treatment and management of chronic fatigue syndrome/myalgic encephalomyelitis: all roads lead to Rome

Oral Bioavailability Enhancement and Anti-Fatigue Assessment of the Andrographolide Loaded Solid Dispersion

Miso Soup Consumption Enhances the Bioavailability of the Reduced Form of Supplemental Coenzyme Q10

Contact Info

Product

Resources

About

Miso Soup Consumption Enhances the Bioavailability of the Reduced Form of Supplemental Coenzyme Q₁₀