Treatment and management of chronic fatigue syndrome/myalgic encephalomyelitis: all roads lead to Rome

Castro-Marrero, Jesús; Sáez-Francàs, Naia; Santillo, Dafna; Alegre, José

doi:10.1111/bph.13702

Cited by 96 publications

(96 citation statements)

References 132 publications

(162 reference statements)

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“…Unfortunately, other highly effective interventions for treating fatigue have yet to be identified. In a recent review evaluating the efficacy of treatments for chronic fatigue syndrome, limited benefits were found for some pharmacological (eg, rintatolimod and rituximab) and nonpharmacological (eg, counseling, behavioral, and rehabilitation programs) approaches. However, the effect sizes associated with these treatments are weak.…”

Section: Discussionmentioning

confidence: 99%

The Role of Sleep Quality and Fatigue on the Benefits of an Interdisciplinary Treatment for Adults With Chronic Pain

et al. 2018

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Background Interdisciplinary chronic pain treatment is effective for reducing pain intensity and pain‐related disability, and for improving psychological function. However, the mechanisms that underlie these treatment‐related benefits are not yet well understood. Sleep problems and fatigue are modifiable factors often comorbid with chronic pain. The goal of this study was to evaluate the role that changes in sleep quality and fatigue might have on the benefits of an interdisciplinary chronic pain treatment. Methods A total of 125 adults with chronic pain participated in a 4‐week interdisciplinary pain management program. Measures of depression, sleep disturbance, fatigue, pain intensity, and physical function were administered at pre‐ and post‐treatment. Three regression analyses were conducted to evaluate the contribution of pre‐ to post‐treatment improvements in fatigue and sleep disturbance to the pre‐ to post‐treatment improvements in pain intensity, disability, and depression, while controlling for demographic characteristics (age and sex) and pain intensity. Results Changes in fatigue and sleep disturbance made independent and significant contributions to the prediction of treatment‐related benefits in pain intensity; improvements in depressive symptoms were predicted by improvements in fatigue, and improvements in disability were only predicted by pre‐treatment and pre‐ to post‐treatment decreases in pain intensity (one of the control variables). Conclusions In addition to sleep, fatigue emerged as a key potential mechanism of multidisciplinary chronic pain treatment‐related improvements, suggesting that interventions including elements that effectively target sleep and fatigue may enhance the efficacy of interdisciplinary chronic pain programs. This possibility should be evaluated in future research.

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Section: Discussionmentioning

confidence: 99%

The Role of Sleep Quality and Fatigue on the Benefits of an Interdisciplinary Treatment for Adults With Chronic Pain

et al. 2018

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“…CFS/ME may also be accompanied by other cardinal symptoms that include orthostatic intolerance, unrefreshing sleep, gastrointestinal discomfort, neuropsychological impairment, anxiety/depression, chronic pain and post-exertional malaise lasting more than 24 h. CFS/ME occurs more often in women than in men and is less common among children and adolescents. Currently, no established diagnostic laboratory tests exist, nor are any FDA-approved drugs available for treatment [1]. …”

Section: Introductionmentioning

confidence: 99%

Circulating extracellular vesicles as potential biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis: an exploratory pilot study

Castro-Marrero

Serrano-Pertierra

Oliveira-Rodríguez

et al. 2018

J of Extracellular Vesicle

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Chronic Fatigue Syndrome (CFS), also known as Myalgic Encephalomyelitis (ME) is an acquired, complex and multisystem condition of unknown etiology, no established diagnostic lab tests and no universally FDA-approved drugs for treatment. CFS/ME is characterised by unexplicable disabling fatigue and is often also associated with numerous core symptoms. A growing body of evidence suggests that extracellular vesicles (EVs) play a role in cell-to-cell communication, and are involved in both physiological and pathological processes. To date, no data on EV biology in CFS/ME are as yet available. The aim of this study was to isolate and characterise blood-derived EVs in CFS/ME. Blood samples were collected from 10 Spanish CFS/ME patients and 5 matched healthy controls (HCs), and EVs were isolated from the serum using a polymer-based method. Their protein cargo, size distribution and concentration were measured by Western blot and nanoparticle tracking analysis. Furthermore, EVs were detected using a lateral flow immunoassay based on biomarkers CD9 and CD63. We found that the amount of EV-enriched fraction was significantly higher in CFS/ME subjects than in HCs (p = 0.007) and that EVs were significantly smaller in CFS/ME patients (p = 0.014). Circulating EVs could be an emerging tool for biomedical research in CFS/ME. These findings provide preliminary evidence that blood-derived EVs may distinguish CFS/ME patients from HCs. This will allow offer new opportunities and also may open a new door to identifying novel potential biomarkers and therapeutic approaches for the condition.

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“…Accordingly, many studies have focused on the development of drugs or therapies with respect to fatigue (24,25). In addition, considering the limitations of available therapies for fatigue in modern medicine, potential alternatives from traditional medicine are worth investing because of their safety, availability, and ease of administration (26).…”

Section: Introductionmentioning

confidence: 99%

Nigella sativa seed extract attenuates the fatigue induced by exhaustive swimming in rats

Rahman

Yang

Kim³

et al. 2017

Biomedical Reports

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Abstract. In previous studies, Nigella sativa (NS) has been studied due to its various physiological and pharmacological activities. However, evidence on the effects of NS on physical fatigue following exhaustive swimming remains limited. In the present study, the authors evaluated the potential beneficial effects of NS against the fatigue activity following exhaustive swimming. Rats were orally administered with NS extract (2 g/kg/day) for 21 days, and the anti-fatigue effect was assessed by exhaustive swimming exercise. The presented results indicated that pre-treatment of NS extract significantly increased the time to exhaustion. In hemodynamic parameters, NS extract increased blood pO 2 and O 2sat , but decreased pCO 2 . For underlying mechanisms, NS extract protected depletion of energy, indicated by increased levels of blood pH, glucose and tissue glycogen contents, and decreased levels of blood lactate, tissue lactic dehydrogenase and creatine kinase, when the NS extract was pre-treated. In addition, the NS extract inhibited oxidative stress following exhaustive swimming, as reflected by the results of increased levels of superoxide dismutase and redox ratio, and decreased the level of malondialdehyde when the NS extract was pre-treated. Collectively, the present study demonstrated that NS extract has an anti-fatigue activity against exhaustive swimming by energy restoration and oxidative-stress defense.

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Treatment and management of chronic fatigue syndrome/myalgic encephalomyelitis: all roads lead to Rome

Cited by 96 publications

References 132 publications

The Role of Sleep Quality and Fatigue on the Benefits of an Interdisciplinary Treatment for Adults With Chronic Pain

The Role of Sleep Quality and Fatigue on the Benefits of an Interdisciplinary Treatment for Adults With Chronic Pain

Circulating extracellular vesicles as potential biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis: an exploratory pilot study

Nigella sativa seed extract attenuates the fatigue induced by exhaustive swimming in rats

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