Effect of coenzyme Q10 on risk of atherosclerosis in patients with recent myocardial infarction

Singh, R. B.; Neki, N.S.; Kartikey, Kumar; Daniel, Pella; Kumar, Adarsh; Niaz, Mohammad A.; Thakur, A. K.

doi:10.1007/978-1-4615-0298-2_11

Cited by 51 publications

(55 citation statements)

References 59 publications

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“…[8][9][10] It has also been reported that CoQ 10 has a hypotensive effect. 7,11,12) In addition, a number of people who usually intake CoQ 10 as a supplement also receive some kinds of drugs to treat high blood pressure.…”

Section: Introductionmentioning

confidence: 95%

Pharmacokinetic Interaction between Nifedipine and Coenzyme Q10 in Rats: A New Type of Drug-Supplement Interaction

Nishimura

Fujimura

Hasegawa

et al. 2010

JOURNAL OF HEALTH SCIENCE

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We examined pharmacokinetic (PK) and pharmacodynamic (PD) interactions between coenzyme Q 10 (CoQ 10 ) and nifedipine (NFP), which is a popular medicine for treating hypertension, and elucidated possible mechanisms for the interaction between CoQ 10 and NFP in rats. The mean plasma concentrations of NFP in rats after the oral administration of NFP (1 mg/kg) with CoQ 10 (75 mg/kg) were increased over the study period and the area under the plasma concentration-time curve (AUC), showed a 1.47-fold increase compared with that of the control. Rats that received NFP with CoQ 10 showed a continuous decrease in the mean blood pressure over the study period compared with the control. There were no significant changes in the PK parameters of NFP after intravenous administration (1 mg/kg) between with and without oral CoQ 10 pretreatment, and also no significant changes in the intestinal excretion of rhodamine 123 (Rho123) or NFP between with and without CoQ 10 were found. In contrast, the portal plasma concentration of NFP after intra loop administration in the presence of CoQ 10 (75 mg/kg) showed a 1.6-fold increase in the AUC value compared with that of the control. As for physicochemical properties, the partition coefficient of NFP showed a marked increase in the presence of CoQ 10 over 10 mg/ml in the organic phase (n-hexane). From on an analysis of the absorbance spectrum, CoQ 10 showed a shift towards a longer wavelength in hydrophobic environments with NFP, suggesting that CoQ 10 reacts with NFP to form a charge-transfer complex due to a pi-cloud between them. In conclusion, it was found that CoQ 10 increases the oral bioavailability of NFP and that this interaction between NFP and CoQ 10 is not caused by metabolism via cycochrome P450 (CYP) 3A in the liver or intestine or by the inhibition of P-glycoprotein function, by the physicochemical interaction between them. Therefore, the solubility of NFP in a hydrophobic environment could be enhanced by forming a chargetransfer complex with CoQ 10 , and it is considered that NFP deviating from a charge-transfer complex may migrate to the blood circulation from the intestinal tract. This mechanism of interaction is considered a new type of drugsupplement interaction.

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Section: Introductionmentioning

confidence: 95%

Pharmacokinetic Interaction between Nifedipine and Coenzyme Q10 in Rats: A New Type of Drug-Supplement Interaction

Nishimura

Fujimura

Hasegawa

et al. 2010

JOURNAL OF HEALTH SCIENCE

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show abstract

“…A number of preclinical and clinical reports on the antioxidant effect of CoQ 10 following oral supplementation were published, including reports on the prevention of LDL peroxidation (Mohr et al, 1992), administration to a patient with cardiovascular disease (Singh et al, 2003), hypertension (Rosenfeldt et al, 2007), angina pectoris (Singh et al, 1998), and neurodegenerative disorders (Parkinson's disease and Huntington's disease) (Young et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Thirteen-Week Repeated Dose Oral Toxicity Study of Coenzyme Q10 in Rats

Honda¹,

Tominaga²,

Oshikata³

et al. 2007

J. Toxicol. Sci.

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-As part of a safety evaluation of Coenzyme Q 10 , a subchronic toxicology study was conducted. Coenzyme Q 10 was repeatedly administered orally to male and female Crl:CD(SD) rats at daily dose levels of 300, 600 and 1200 mg/kg for 13 weeks. Neither death nor any toxicological signs were observed in any group during the administration period. No change related to the test substance administered was observed in any group with regard to body weight, food consumption, ophthalmoscopy, hematology, blood biochemistry, necropsy, organ weights or histopathology. Based on these results, the nonobserved-adverse-effect level (NOAEL) of Coenzyme Q 10 was considered to be 1200 mg/kg/day for male and female rats under these study conditions.

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“…The CoQ10 reduced cholesterol metabolism in the plasma of patients with myocardial infarction (Singh et al, 2003) and in diabetic rats (Modi et al, 2006). The CoQ9, a major coenzyme Q in rats, decreases plasma total cholesterol concentration and suppresses hepatic cholesterogenesis (Krishnaiah and Ramasarma, 1970).…”

Section: Coenzyme Q10 On Lipid Metabolismmentioning

confidence: 99%

Dietary Essentiality I: Coenzyme Q10 Conditionally Essential-Review

Gopi¹,

Kumar²,

Elaiyaraja³

et al. 2015

Asian J. of Animal and Veterinary Advances

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The essentiality of nutrients keeps on changing with the advancement in nutritional research and genetic gain. The genetic gain especially in poultry sector is very high which results in increase in nutrient requirement of both the essential and non-essential nutrients. For the rapid growth the requirement of essential nutrients reaches many folds which are in direct relation with the performance, but the requirement for non-essential nutrients is an indirect one. Most of the dispensable amino acids, vitamin C, carnitine, etc. which are being synthesized endogenously are now a days unable to meet the birds requirements that warrants the dietary supply. Another important nutrient is coenzyme Q10 (CoQ10) which endogenously synthesized is now gaining much attention as a supplement for fast growing broilers. The CoQ10 can be termed as multi-functionary as each and every cell in the body needs this but quantity is being high for very active organs like heart, lungs, liver, kidney, etc. They are essential for cellular oxidative phosphorylation and regenerative antioxidant. The supplementation of CoQ10 improved the feed efficiency with reducing the electron leaks from mitochondria and increases total antioxidant capacity. For this property, CoQ10 is widely used in human medicine especially persons suffering from cardiac, neurological disorder, hypercholesterolemic condition and also even in cancer. The CoQ10 in poultry draws first attention when it is found to reducing the ascites mortality in marketable broilers. Thereafter, the advantages of CoQ10 is started to exploit with much attention to ascites, feed efficiency, cholesterol lowering effect nutraceutical and nutrigenomic property both in poultry and swine industry.

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Effect of coenzyme Q10 on risk of atherosclerosis in patients with recent myocardial infarction

Cited by 51 publications

References 59 publications

Pharmacokinetic Interaction between Nifedipine and Coenzyme Q10 in Rats: A New Type of Drug-Supplement Interaction

Pharmacokinetic Interaction between Nifedipine and Coenzyme Q10 in Rats: A New Type of Drug-Supplement Interaction

Thirteen-Week Repeated Dose Oral Toxicity Study of Coenzyme Q10 in Rats

Dietary Essentiality I: Coenzyme Q10 Conditionally Essential-Review

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