Effect of cobalt(II) complexes with dipyridylamine and salicylaldehydes on cultured tumor and non-tumor cells: Synthesis, crystal structure investigations and biological activity

New Type of Single Chain Magnet: Pseudo-One-Dimensional Chain of High-Spin Co(II) Exhibiting Ferromagnetic Intrachain Interactions

“…Differences in the overall shapes of the coordination cations in 1 and 2 (Figure ) result mainly from the inversion of the boat conformation of the six-membered chelate rings formed by cis -positioned dpamH ligands. These two structural forms with inverted boats are typical for bis-dpamH octahedral metal complexes and are nearly equally populated in the crystals . The actual form adopted by the flexible dpamH ligands in the coordination entity is most probably affected by the crystal packing forces as in the two limiting forms the pair of N–H hydrogen-bond donor groups of dpamH ligands is oriented differently (Figure ).…”

“…All complexes were prepared under argon conditions, and well-degassed solutions have been used to avoid oxidation of the cobalt. The two cationic mixed-ligand complexes Co(dpamH) 2 (X-salo)] + were prepared according to the following general procedure, under argon atmosphere, while well degassed solutions were used to avoid oxidation of the cobalt . To an ethanolic solution (20 mL) of 291 mg of hexahydrate cobalt(II) nitrate was added 342 mg of dpamH under stirring and dropwise an ethanolic solution of 167 mg for 5-nitro-salicylaldehydeH and/or 152 mg for 3-methoxy-salicylaldehydeH substituted salicylaldehyde and 101 mg or 0.14 mL NEt 3 .…”

Copper(ii) complexes of salicylaldehydes and 2-hydroxyphenones: synthesis, structure, thermal decomposition study and interaction with calf-thymus DNA and albumins

“…The last decade we have initiated in our laboratory the synthesis and characterization of transition metal complexes with carbonyl compounds derived from salicylaldehyde and 2-OH-phenone ligands. 16,[30][31][32][33][34][35] Especially, we have been focused on the synthesis of metal complexes with substituted salicylaldehydes and their interaction with DNA. Previous studies showed that zinc(II) complexes with salicylaldehydes or 2-hydroxybenzophenones presented interesting results concerning their binding to calf-thymus DNA, 33,34 while Co(II) analogues in the presence of the nitrogen-donor ligand 2,2 0 -dipyridylamine have showed anticancer activity.…”

“…Previous studies showed that zinc(II) complexes with salicylaldehydes or 2-hydroxybenzophenones presented interesting results concerning their binding to calf-thymus DNA, 33,34 while Co(II) analogues in the presence of the nitrogen-donor ligand 2,2 0 -dipyridylamine have showed anticancer activity. 32 As continuation of our research, seven neutral mononuclear copper(II) complexes with the ligands HL ¼ substituted 2hydroxy-benzaldehydes (salicylaldehyde, abbreviated as X-saloH), or with 2-hydroxy-phenones (abbreviated as ketoH) (Scheme 1), under the general formula [Cu(L) 2 (S) n ], (where S ¼ solvent CH 3 OH or H 2 O and n ¼ 0, 1 or 2), have been prepared and characterized and their interaction with DNA and albumins has been studied. Five of them are novel compounds, while the crystal structures for four of them were veried by single-crystal X-ray diffraction analysis, [Cu(5-NO 2 -salo) 2 2) have recently been published by our group.…”

Modifying Alkylzinc Reactivity with 2,2′‐Dipyridylamide: Activation of tBuZn Bonds for para‐Alkylation of Benzophenone

“…To break this template and develop new structural motifs that could stimulate new reactivity we have investigated replacing monofunctional TMP with multifunctional 2,2′-dipyridylamide [dpa, (2-NC 5 H 4 ) 2 N]. Offering three potential ligating N sites, this N-bridged bis(N heterocycle) finds utility in a diverse range of applications including medicine,[ 3 ] catalysis,[ 4 ] photoluminescence,[ 5 ] and supramolecular chemistry. [ 6 ] Herein we report a remarkable set of novel structures incorporating dpa into neutral zinc, sodium zincate, and potassium zincate modifications containing tert -butyl ligands.…”