Copper(<scp>ii</scp>) complexes of salicylaldehydes and 2-hydroxyphenones: synthesis, structure, thermal decomposition study and interaction with calf-thymus DNA and albumins

Zianna, Ariadni; Psomas, George; Hatzidimitriou, Antonios G.; Lalia‐Kantouri, Maria

doi:10.1039/c4ra16484a

Cited by 43 publications

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“…Our interest is based on the synthesis of metal complexes with substituted salicylaldehydes and their interaction with DNA. Previous studies showed that zinc(II) and copper(II) complexes with substituted salicylaldehydes or 2-hydroxybenzophenones have interesting binding to calf-thymus (CT) DNA [32,33,35], while Co(II) complexes in the presence of the nitrogen-donor ligand 2,2'-dipyridylamine (dpamH) exhibited anticancer activity [31].…”

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confidence: 99%

Cadmium(II) complexes of 5-nitro-salicylaldehyde and α-diimines: synthesis, structure and interaction with calf-thymus DNA

Zianna

Šumar-Ristović

Psomas

et al. 2015

Journal of Coordination Chemistry

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complexes of 5-nitro-salicylaldehyde and α-diimines: Synthesis, structure and interaction with calf-thymus DNA, Journal of Coordination Chemistry, Five Cd(II) complexes with the anion of 5-NO 2 -salicylaldehydeH (5-NO 2 -saloH) in the absence or presence of the α-diimine 1,10-phenanthroline (phen), 2,2'-dipyridylamine (dpamH), 2,2'-dipyridine (bipy) or 2,9-dimethyl-1,10-phenanthroline (neoc) were synthesized and characterized as (2), [Cd(5-NO 2 -salo) 2 (dpamΗ)] (3), [Cd 3 (5-NO 2 -salo) 6 (bipy) 2 ] (4) and [Cd(5-NO 2salo)(neoc)(NO 3 )] 2 (5). Based on spectroscopic results (IR, UV, NMR), elemental analysis and conductivity measurements an octahedral geometry around cadmium metal ion is suggested, with the 5-NO 2 -salicylaldehyde ligand having different coordination modes. The structures determined by X-ray crystallography verified neutral mononuclear 1-3 and trinuclear 4.Simultaneous TG/DTG-DTA technique was used to analyze the thermal behavior of 1, 2 and 3.The complexes bind tightly to calf-thymus DNA mainly by intercalation, as concluded by DNAviscosity measurements and exhibit significant displacement of EB from the EB-DNA complex.

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confidence: 99%

Cadmium(II) complexes of 5-nitro-salicylaldehyde and α-diimines: synthesis, structure and interaction with calf-thymus DNA

Zianna

Šumar-Ristović

Psomas

et al. 2015

Journal of Coordination Chemistry

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“…8). [30,31] It was confirmed the addition of Cu 2+ results electron transfer redox (oxidation-reduction) process. The anodic peaks for 4MHEB-Cu 2+ ion appeared at Epa = -0.0242 V and cathodic peak Epc = +0.3027 V while anodic peak at Epa = -0.1470 V and cathodic peak Epc = +0.5890 V for 4MHEB.…”

Section: Cyclic Voltammetric Studymentioning

confidence: 80%

Synthesis and computational mechanistic studies of copper selective molecular receptor

Mohan

Modi

Patel

et al. 2020

Vietnam Journal of Chemistry

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Although numerous molecular receptors for Cu 2+ have been reported, it is not obvious to find a simple molecule as a selective receptor for Cu 2+ . Here we create a molecular receptor 4MHEB for Cu 2+ metal ions. Observation of a new absorption band near 282 nm in UV-visible spectra and enhancement in fluorescence intensity in emission spectra justify the binding 4MHEB:Cu 2+ binding. Inspection in shifting of IR bands, different thermal behavior and oxidation and reduction peaks of complex shows binding of 4MHEB:Cu 2+ . HRMS m/z 322.0328, Benesi-Hildebrand method and Job's Plot results 1:1 (4MHEB:Cu 2+ ) binding stoichiometry with the binding affinity K = 1.751×10 5 M -1 . The docked pose of 4MHEB with Cu 2+ ion, Key transitions, % Contribution was calculated by computational studies.

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“…In pursuit of developing better copper based anti-inflammatory drugs which can be administered orally, intravenously or even transdermally, they have designed and synthesized two ligands, N, NO-di (aminoethylene)-2,6pyridinedicarbonylamine (L1) and bis-(N, Ndimethylethyl)-2,6-pyridinedicarboxamide (L2). L1 and L2 both have pyridyl groups which are found in most of the non-steroidal anti-inflammatory drugs (NSAIDs) [48]. A class of quinoline based compounds has been explored and found to have the ability to inhibit platelet-activating factor (PAF) synthesis which also contributes to antiinflammatory properties [49].…”

Section: Anti-inflammatory Agentsmentioning

confidence: 99%

Dynamics of Transition Metal and their Application in Biomedical Industry

Malpaharia¹,

Pandey²

2020

Int.J.Curr.Microbiol.App.Sci

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Copper(ii) complexes of salicylaldehydes and 2-hydroxyphenones: synthesis, structure, thermal decomposition study and interaction with calf-thymus DNA and albumins

Abstract: The characterized copper(ii) complexes with substituted salicylaldehydes and 2-hydroxyphenones exhibit enhanced affinity for DNA and albumins in comparison to free ligands.

Cited by 43 publications

References 86 publications

Cadmium(II) complexes of 5-nitro-salicylaldehyde and α-diimines: synthesis, structure and interaction with calf-thymus DNA

Cadmium(II) complexes of 5-nitro-salicylaldehyde and α-diimines: synthesis, structure and interaction with calf-thymus DNA

Synthesis and computational mechanistic studies of copper selective molecular receptor

Dynamics of Transition Metal and their Application in Biomedical Industry

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