Effect of coatings and surface modification on porous silicon nanoparticles for delivery of the anticancer drug tamoxifen

Haidary, Sazan M.; Mohammed, Awaz B.; Córcoles, Emma P.; Ali, N. K.; Ahmad, Mohd Ridzuan

doi:10.1016/j.mee.2016.03.051

Cited by 25 publications

(14 citation statements)

References 46 publications

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“…In order to increase the available surface area, enhance the field–molecule interaction strength and extend the application field of the FRET biosensor, porous materials have been proposed as an extension to biosensors. Porous silicon (PS) presents an almost ideal optical sensor platform, with potential in a diverse range of applications from trace environmental to label-free monitoring of biomolecular interaction [ 17 , 29 , 30 ]. Research interest has moved toward sensing application areas of PS because of its sponge-like structure and large internal surface-to-volume ratio which can reach several hundreds of square meters per cubic centimeter.…”

Section: Introductionmentioning

confidence: 99%

Efficient Fluorescence Resonance Energy Transfer between Quantum Dots and Gold Nanoparticles Based on Porous Silicon Photonic Crystal for DNA Detection

Zhang

Jia

2017

Sensors

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A novel assembled biosensor was prepared for detecting 16S rRNA, a small-size persistent specific for Actinobacteria. The mechanism of the porous silicon (PS) photonic crystal biosensor is based on the fluorescence resonance energy transfer (FRET) between quantum dots (QDs) and gold nanoparticles (AuNPs) through DNA hybridization, where QDs act as an emission donor and AuNPs serve as a fluorescence quencher. Results showed that the photoluminescence (PL) intensity of PS photonic crystal was drastically increased when the QDs-conjugated probe DNA was adhered to the PS layer by surface modification using a standard cross-link chemistry method. The PL intensity of QDs was decreased when the addition of AuNPs-conjugated complementary 16S rRNA was dropped onto QDs-conjugated PS. Based on the analysis of different target DNA concentration, it was found that the decrease of the PL intensity showed a good linear relationship with complementary DNA concentration in a range from 0.25 to 10 μM, and the detection limit was 328.7 nM. Such an optical FRET biosensor functions on PS-based photonic crystal for DNA detection that differs from the traditional FRET, which is used only in liquid. This method will benefit the development of a new optical FRET label-free biosensor on Si substrate and has great potential in biochips based on integrated optical devices.

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Section: Introductionmentioning

confidence: 99%

Efficient Fluorescence Resonance Energy Transfer between Quantum Dots and Gold Nanoparticles Based on Porous Silicon Photonic Crystal for DNA Detection

Zhang

Jia

2017

Sensors

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“…Then, BPMQ was prepared via the hydrosilylation reaction of HMQ and eugenol, using H 2 PtCl 6 as an additional catalyst. Theoretically, this reaction of Si–H and vinyl is in the molar ratio of 1:1, but to overcome side effects caused by the lively reaction of Si–H in HMQ, a slightly excess molar ratio of HMQ to eugenol was used to promote the reaction more completely, and a molar ratio of 1.02:1 of the value of Si–H/–CH=CH 2 was chosen in this reaction [23]. The preparation routes of HMQ and BPMQ are shown in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

A Simple Preparation Route for Bio-Phenol MQ Silicone Resin via the Hydrosilylation Method and its Autonomic Antibacterial Property

Liang

et al. 2019

Polymers

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MQ silicone resins represent a broad range of hydrolytic condensation products of monofunctional silane (M units) and tetrafunctional silane (Q units). In this work, a Bio-Phenol MQ silicone resin (BPMQ) was designed and synthesized by the hydrosilylation of hydrogen containing MQ silicone resin and eugenol in the presence of chloroplatinic acid. The structure, thermal property, and antibacterial property against Escherichia coli of the modified MQ silicone resin were investigated. The results showed that BPMQ has been prepared successfully, and the thermal stability of this modified polymer improved significantly because of the introduction of phenyl in eugenol. The temperature at the maximum degradation rate increased from 250 °C to 422.5 °C, and the residual yields mass left at 600 °C were increased from 2.0% to 28.3%. In addition, its antibacterial property against Escherichia coli was also enhanced markedly without adding any other antimicrobial agents. This improved performance is ascribed to special functional groups in the structure of eugenol. The BPMQ polymer is expected to be applied to pressure-sensitive adhesives and silicone rubber products for the biomedical field due to its reinforcing effect and antioxidant quality.

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“…The highly sophisticated immune system of the human body makes intravenous delivery of inorganic particles problematic (Haidary et al 2016). Despite the challenges related to the intravenous route, the high hopes for rapidly developing nanotechnology have initiated an intensive research of targeted drug delivery.…”

Section: Intravenous Deliverymentioning

confidence: 99%

“…Recently new approaches to avoid rapid clearance of nanoparticles and improved homing efficacy have been introduced (McInnes et al 2016;Haidary et al 2016;Parodi et al 2013). For example, Xu et al used porous silicon discoidal particles as an injectable nanoparticle generator to delivery polymeric drug system which spontaneously forms nanoparticles when released at target site.…”

Section: Intravenous Deliverymentioning

confidence: 99%

Drug Delivery with Porous Silicon

Salonen¹

2016

Handbook of Porous Silicon

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Biodegradable porous silicon is under preclinical assessment for a range of drug delivery applications, and in this updated review, data is now available on more than 30 active pharmaceutical ingredients (API). Studies to date on oral, subcutaneous, intravenous, intravitreal, and intratumoral modes of delivery are covered. Sustained delivery of an increasing range of biological actives, like peptides and antibodies, is under evaluation, as are bioavailability enhancements for small hydrophobic APIs. Both the merits and existing challenges of this nanostructured carrier are raised.

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Effect of coatings and surface modification on porous silicon nanoparticles for delivery of the anticancer drug tamoxifen

Cited by 25 publications

References 46 publications

Efficient Fluorescence Resonance Energy Transfer between Quantum Dots and Gold Nanoparticles Based on Porous Silicon Photonic Crystal for DNA Detection

Efficient Fluorescence Resonance Energy Transfer between Quantum Dots and Gold Nanoparticles Based on Porous Silicon Photonic Crystal for DNA Detection

A Simple Preparation Route for Bio-Phenol MQ Silicone Resin via the Hydrosilylation Method and its Autonomic Antibacterial Property

Drug Delivery with Porous Silicon

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