Effect of climate therapy at Gran Canaria on vitamin D production, blood glucose and lipids in patients with psoriasis

Osmancevic, Amra; Nilsen, Lill Tove Norvang; Landin‐Wilhelmsen, Kerstin; Søyland, Elisabeth; Torjesen, Peter A.; Hagve, Tor‐Arne; Nenseter, Marit S.; Krogstad, Anne‐Lene

doi:10.1111/j.1468-3083.2009.03245.x

Cited by 40 publications

(47 citation statements)

References 30 publications

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“…Serum levels of 25(OH)D increased during treatment with artificial UV (BUVB and NBUVB) and during heliotherapy (56)(57)(58)(59). The increase in 25(OH)D was higher in the BUVB treated patients when compared to the NBUVB (p=0.008) and heliotherapy (p=0.017) treated groups.…”

Section: The Effects Of Phototherapy On Vitamin D Status In Patients mentioning

confidence: 77%

“…Low-dose NBUVB treatment significantly increased vitamin D status in patients with psoriasis, atopic eczema and other skin disorders with low initial levels of 25(OH)D (60,61). Within the following intervention studies, age showed no correlation with the observed increase in 25(OH)D levels (57,58,62). This indicates the skin's capacity to produce vitamin D3 during phototherapy of psoriasis is independent of the patient's age or psoriasis severity.…”

Section: The Effects Of Phototherapy On Vitamin D Status In Patients mentioning

confidence: 79%

“…All patients reached serum levels of 30 ng/ml (75 nmol/l) after two weeks of sun exposure (62). A circulating level of 25(OH)D of >30 ng/ml, or >75 nmol/L, appears to be necessary to maximize the health benefits of vitamin D(6).…”

Section: The Effects Of Phototherapy On Vitamin D Status In Patients mentioning

confidence: 99%

“…Patients reached their plateau of daily sun exposure after the first week. It is likely that vitamin D production was most prominent during the first week, when the patients experienced redness and some of them even got sunburned (56).…”

Section: The Effects Of Phototherapy On Vitamin D Status In Patients mentioning

confidence: 99%

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UVB and Vitamin D in Psoriasis

Osmancevic¹

2012

Psoriasis

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Section: The Effects Of Phototherapy On Vitamin D Status In Patients mentioning

confidence: 77%

Section: The Effects Of Phototherapy On Vitamin D Status In Patients mentioning

confidence: 79%

Section: The Effects Of Phototherapy On Vitamin D Status In Patients mentioning

confidence: 99%

Section: The Effects Of Phototherapy On Vitamin D Status In Patients mentioning

confidence: 99%

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UVB and Vitamin D in Psoriasis

Osmancevic¹

2012

Psoriasis

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“…Osmancevic et al (165) showed that psoriasis symptoms improved in twenty patients aged 25-65 years with 15 d of climate therapy in Gran Canaria. The LDL:HDL ratio decreased from 2·4 to 1·9 mmol/l (P, 0·001), apoA1 and HDL-cholesterol concentration increased and apoB decreased during the sun exposure period.…”

Section: Dyslipidaemiamentioning

confidence: 99%

Vitamin D and cardiometabolic health: a review of the evidence

Muldowney

Kiely

2010

Nutr. Res. Rev.

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The cardiometabolic syndrome (MetS) is a clustering of related metabolic abnormalities including abdominal adiposity, insulin resistance, hypertension, dyslipidaemia and increased inflammatory and thrombotic markers, which is linked to increased risk of type 2 diabetes, CVD and overall mortality. Several cross-sectional and prospective studies have shown an association between low vitamin D status, as indicated by concentrations of serum 25-hydroxyvitamin D (s25(OH)D), and increased prevalence of the MetS and individual CVD risk factors. These epidemiological observations are supported by mechanistic studies but experimental data are limited. The available data from intervention studies are largely confounded as most vitamin D supplementation trials were mainly carried out to explore the role of Ca in CVD and include Ca in the treatment arms. Inadequate consideration of seasonal effects on s25(OH)D concentrations is also a common design flaw in most studies. Further complications arise from shared risk factors such as adiposity and ageing, which predispose individuals to exhibit both a more pronounced risk profile and relatively lower s25(OH)D concentrations. In conclusion, while epidemiological associations are promising and a rationale for low vitamin D status as a potentially modifiable risk factor for CVD is supported by mechanistic data, suitable experimental data from appropriately designed trials are just beginning to emerge. As yet, this body of literature is too immature to draw firm conclusions on the role of vitamin D in CVD prevention. Carefully controlled vitamin D trials in well-described population groups using intervention doses that are titrated against target s25(OH)D concentrations could yield potentially valuable outcomes that may have a positive impact on CVD risk modification.

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